Increased uncoupling protein-2 levels in β-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action

Diabetes

Volumn 50, Issue 6, 2001, Pages 1302-1310

  Chan, Catherine B ^a   De Leo, Domenica ^b   Joseph, Jamie W ^b   McQuaid, Timothy S ^a   Ha, Xiao Fang ^b   Xu, Fang ^b   Tsushima, Robert G ^b   Pennefather, Peter S ^b   Salapatek, Anne Marie F ^b   Wheeler, Michael B ^b  

^a UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLIBENCLAMIDE; GLUCOSE; POTASSIUM CHANNEL; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HYPERPOLARIZATION; INSULIN RELEASE; MITOCHONDRIAL MEMBRANE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN;

EID: 0034990987     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.6.1302     Document Type: Article

References (39)

1. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
2. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
3. Uncoupling protein negatively regulates insulin secretion
4. Thermogenic mechanisms in brown fat
5. Transport function and regulation of mitochondrial uncoupling proteins 2 and 3
6. Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2
7. Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves β-cell function
8. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation
9. Energy metabolism in islets Langerhans
10. Glucose and alpha-ketoisocaproate induce transient inward currents in rat pancreatic beta cells
11. Mitochondria and diabetes: Genetic, biochemical, and clinical implications of the cellular energy circuit
12. Relationships between energy level and insulin secretion in isolated rat islets of Langerhans: A study at various pH values
13. Electrophysiology of the pancreatic beta-cell
14. + channel subunit Kir6.2 in mouse pancreas
15. Properties and functions of ATP sensitive K-channels
16. Evidence for defective glucose sensing by islets of fa/fa obese Zucker rats
17. Quantification of gene expression over a wide range by polymerase chain reaction
18. 2 synthase-2 expression in ovine intrauterine tissue during the course of labor
19. - mice
20. The effect of GLP-1 on insulin sensitivity in diabetic dogs
21. Inducible genetic suppression of neuronal excitability
22. Mutations to the third cytosolic domain of the GLP-1 receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells
23. Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells
24. Selective inhibition of glucose-stimulated beta-cell activity by an anion channel inhibitor
25. ATP channel-dependent and -independent pathways of insulin secretion in isolated islets from fa/fa Zucker rats
26. + permeability of the B-cell membrane
27. Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: Their gene expression in rats fed high-fat diet
28. Defective fatty acid-mediated β-cell compensation in Zucker diabetic fatty rats: Pathogenic implications for obesity-dependent diabetes
29. Glucose down regulates the expression of the PPAR gene in the pancreatic β-cell
30. Uncoupling protein 2: A possible link between fatty acid excess and impaired glucose-induced insulin secretion?
31. Uncoupling proteins 2 and 3: Potential regulators of mitochondrial energy metabolism
32. Pharmacological therapy for type 2 diabetes mellitus
33. 2+ concentration in pancreatic β-cells
34. The ABCs of ATP-sensitive potassium channels: More pieces of the puzzle
35. ATP channel deficient mice
36. Glucose generates sub-plasma membrane ATP microdomains in single islet β-cells: Potential role for strategically located mitochondria
37. The pancreatic beta-cell as fuel sensor: An electrophysiologist's viewpoint
38. Triggering and amplifying pathways of regulation of insulin secretion by glucose
39. Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis