Free fatty acid-induced β-cell defects are dependent on uncoupling protein 2 expression

Journal of Biological Chemistry

Volumn 279, Issue 49, 2004, Pages 51049-51056

  Joseph, Jamie W ^a   Koshkin, Vasilij ^a   Saleh, Monique C ^c   Sivitz, William I ^b   Zhang, Chen Yu ^d   Lowell, Bradford B ^d   Chan, Catherine B ^c   Wheeler, Michael B ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; FATTY ACIDS; FLUORESCENCE; GLUCOSE; INSULIN; METABOLISM; OXIDATION; POLARIZATION; PROTEINS; TOXICITY;

PANCREAS; UNCOUPLING PROTEINS; VITRO; VIVO;

CELLS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; FATTY ACID; GLUCOSE; GREEN FLUORESCENT PROTEIN; INSULIN; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; CYTOSOL; EXPOSURE; FATTY ACID OXIDATION; HYPERPOLARIZATION; INSULIN RELEASE; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OXIDATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOVIRIDAE; ANIMALS; BLOTTING, WESTERN; CALCIUM; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; FATTY ACIDS, NONESTERIFIED; GLUCOSE; INSULIN; ION CHANNELS; ISLETS OF LANGERHANS; LIPID METABOLISM; MALE; MEMBRANE POTENTIALS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OBESITY; OXYGEN; PALMITIC ACID; PHENOTYPE; POLYMORPHISM, GENETIC; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TRANSGENES; TRIGLYCERIDES;

ANIMALIA;

EID: 10944265062     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409189200     Document Type: Article

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