Reduced expression of PTEN correlates with breast cancer progression

Human Pathology

Volumn 33, Issue 4, 2002, Pages 405-409

  Bose, Shikha ^a,b,c   Crane, Allison ^a,b,c   Hibshoosh, Hanina ^a,b,c   Mansukhani, Mahesh ^a,b,c   Sandweis, Lynn ^a,b,c   Parsons, Ramon ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Columbia University ^*  (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Carcinoma in situ; DCIS; Immunohistochemistry; Invasive breast carcinoma; PTEN expression

Indexed keywords

PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ANEUPLOIDY; ARTICLE; BREAST CANCER; CANCER INVASION; CANCER STAGING; CARCINOMA IN SITU; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; GENE OVEREXPRESSION; GENOTYPE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PROMOTER REGION; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

EID: 0036279974     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2002.124721     Document Type: Article

References (24)

1. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
2. PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
3. Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
4. MMAC 1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
5. Somatic mutations of PTEN in glioblastoma multiforme
6. PTEN gene mutations are seen in high-grade but not in low-grade gliomas
7. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
8. Mutations in PTEN are frequent in endometrial carcinoma but are rare in other common gynecological malignancies
9. Allelic loss of chromosome 10q23 is associated with invasion in breast carcinomas
10. Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus
11. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas
12. Exclusion of a major role for the PTEN tumour-suppressor gene in breast carcinomas
13. Germline mutations in PTEN are an infrequent cause of genetic predisposition to breast cancer
14. No evidence for germline PTEN mutations in families with breast and brain tumours
15. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in PTEN +/- mice
16. Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma
17. Allelotype of human breast carcinoma: A second major site for loss of heterozygosity is on chromosome 6q
18. Allelotype of breast cancer: Cumulative allele losses promote tumor progression in primary breast cancer
19. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
20. Loss of expression of the pten gene protein product is associated with poor outcome in breast cancer
21. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
22. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
23. Profiling the downstream genes of tumor suppressor PTEN in lung cancer cells by complementary DNA microarray