Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo

Gene Therapy

Volumn 10, Issue 23, 2003, Pages 1961-1969

  Saito, Y ^a   Swanson, X ^b   Mhashilkar, A M ^b   Oida, Y ^a   Schrock, R ^b   Branch, C D ^a   Chada, S ^b   Zumstein, L ^b   Ramesh, R ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b Introgen Therapeutics Inc   (United States)

Author keywords

Apoptosis; Cancer; Cell cycle; Colorectal; PTEN

Indexed keywords

ADENOVIRUS VECTOR; FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; GENE TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; TUMOR XENOGRAFT; VIRAL GENE DELIVERY SYSTEM; WILD TYPE;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL CYCLE; CELL DIVISION; COLORECTAL NEOPLASMS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; TRANSCRIPTION FACTORS; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEINS;

ADENOVIRIDAE; ANIMALIA;

EID: 0242287934     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302100     Document Type: Article

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