Transient receptor potential ion channels as targets for the discovery of pain therapeutics

Current Opinion in Investigational Drugs

Volumn 6, Issue 1, 2005, Pages 48-57

  Krause, James E ^a   Chenard, Bertrand L ^a   Cortright, Daniel N ^a  

^a NEUROGEN CORPORATION   (United States)

Author keywords

Chronic pain; Neuropathic pain; Nociceptor; TRP channel; TRPA1; TRPV1; TRPV4

Indexed keywords

ANALGESIC AGENT; ANANDAMIDE; ANTINOCICEPTIVE AGENT; ARACHIDONIC ACID DERIVATIVE; CAPSAICIN; CAPSAZEPINE; DD 161515; JYL 1421; N [2 (3 DIMETHYLBENZYL) 3 PIVALOYLOXYPROPYL] N' [3 FLUORO 4 (METHYLSULFONYLAMINO)BENZYL]THIOUREA; NDT 9525276; NICOTINIC RECEPTOR; OLVANIL; RESINIFERATOXIN; RUTHENIUM RED; SB 366791; SC 0030; THIOUREA DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 AGONIST; VANILLOID RECEPTOR 1 ANTAGONIST; VANILLOID RECEPTOR 4; VOLTAGE GATED POTASSIUM CHANNEL;

ANALGESIC ACTIVITY; BLADDER DISEASE; DISEASE MODEL; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GASTROINTESTINAL DISEASE; HEAT SENSITIVITY; HUMAN; HYPERALGESIA; IMMUNOREACTIVITY; INFLAMMATION; LUNG DISEASE; NOCICEPTIVE RECEPTOR; NONHUMAN; PAIN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; RECEPTOR INTRINSIC ACTIVITY; REVIEW; SIGNAL TRANSDUCTION; SKIN; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; CALCIUM CHANNELS; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; NOCICEPTORS; PAIN; TRPC CATION CHANNELS;

EID: 12544259812     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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