N-(3-acyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues: Novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor

Journal of Medicinal Chemistry

Volumn 46, Issue 14, 2003, Pages 3116-3126

  Lee, Jeewoo ^a   Lee, Jiyoun ^a   Kang, Myungshim ^a   Shin, Myoungyoup ^a   Kim, Ji Min ^a   Kang, Sang Uk ^a   Lim, Ju Ok ^a   Choi, Hyun Kyung ^a   Suh, Young Ger ^a   Park, Hyeung Geun ^a   Oh, Uhtaek ^a   Kim, Hee Doo ^b   Park, Young Ho ^c   Ha, Hee Jin ^d   Kim, Young Ho ^d   Toth, Attila ^e   Wang, Yun ^e   Tran, Richard ^e   Pearce, Larry V ^e   Lundberg, Daniel J ^e   Blumberg, Peter M ^e   more..

^a Seoul National University   (South Korea)

^b Sookmyung Women's University   (South Korea)

^c AmorePacific Corporation   (South Korea)

^d Digital Bio Technology Co   (South Korea)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; CAPSAZEPINE; MESYLIC ACID DERIVATIVE; N (3 ACYLOXY 2 BENZYLPROPYL) N' [4 (METHYLSULFONYLAMINO)BENZYL]THIOUREA; N [2 (3,4 DIMETHYLBENZYL) 3 PIVALOYLOXYPROPYL] N' [3 FLUORO 4 (METHYLSULFONYLAMINO)BENZYL]THIOUREA; PHENOL; RESINIFERATOXIN; SULFONAMIDE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL MODIFICATION; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; MOUSE; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; CALCIUM; CAPSAICIN; CHO CELLS; CRICETINAE; LIGANDS; MALE; MICE; MICE, INBRED ICR; RATS; RECEPTORS, DRUG; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIOUREA;

EID: 0038460841     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030089u     Document Type: Article

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