Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation

Journal of Neuroscience

Volumn 21, Issue 22, 2001, Pages 8697-8706

  Kuzhikandathil, Eldo V ^a   Wang, Haibin ^a   Szabo, Tamas ^b   Morozova, Natasha ^a   Blumberg, Peter M ^b   Oxford, Gerry S ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Capsaicin; CHO cell; Dominant negative; Mutation; Pain; Resiniferatoxin; VR1

Indexed keywords

AMINO ACID DERIVATIVE; CAPSAICIN; PROTON; RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; RESINIFERATOXIN; VANILLOID RECEPTOR;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CHO CELL; CONTROLLED STUDY; GENE DISRUPTION; GENE EXPRESSION; GENE MUTATION; GENETIC CONSERVATION; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR AFFINITY; RECEPTOR UPREGULATION;

EID: 0035889970     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-22-08697.2001     Document Type: Article

References (23)

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6. 3 purinoceptor and IB4 binding sites
7. Acid potentiation of the capsaicin receptor determined by a key extracellular site
8. Analysis of the native quaternary structure of vanilloid receptor 1
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10. 2- dependence in rat trigeminal ganglion cells
11. Functional stoichiometry of Shaker potassium channel inactivation
12. Use of a dominant negative mutant of VR1 to explore capsaicin receptor stoichiometry
13. Mutations in the putative sixth transmembrane domain provide evidence for multimerization of the VR1 receptor
14. Cloning of a stretch-inhibitable nonselective cation channel
15. Vanilloid (capsaicin) receptors and mechanisms
16. Identification of alpha-1-acid glycoprotein (orosomucoid) as a major vanilloid binding protein in serum
17. The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons
18. Regions responsible for the assembly of inwardly rectifying potassium channels
19. The cloned capsaicin receptor integrates multiple pain-producing stimuli
20. Min K channels form by assembly of at least 14 subunits
21. The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat
22. + channel
23. + channel by mutation of the H5 region