Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: Overexpression of protein kinase Cε in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia

Diabetes

Volumn 50, Issue 3, 2001, Pages 584-592

  Ikeda, Yukio ^a   Olsen, Grith S ^a   Ziv, Ehud ^b   Hansen, Lone L ^a   Busch, Anna K ^a   Hansen, Bo F ^c   Shafrir, Eleazar ^b   Mosthaf Seedorf, Luitgard ^a,d  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c NOVO NORDISK A S   (Denmark)

^d Lilly Research Laboratories   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; INSULIN; INSULIN RECEPTOR; PROTEIN KINASE B; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CYTOLYSIS; DIABETES MELLITUS; DISEASE COURSE; DISEASE PREDISPOSITION; DOWN REGULATION; FEMALE; GENE OVEREXPRESSION; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN RESISTANCE; MALE; NONHUMAN; NUTRITION; PRIORITY JOURNAL; PSAMMOMYS OBESUS; RAT; SKELETAL MUSCLE;

EID: 0035126784     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.3.584     Document Type: Article

References (36)

1. Psammomys obesus (sand rat): Nutritionally induced NIDDM-like syndrome on a thrifty gene background
2. Development and consequences of insulin resistance: Lessons from animals with hyperinsulinaemia
3. Characterization of stages in the development of obesity-syndrome in sand rat (Psammomys obesus)
4. Irreversibility of nutritionally induced NIDDM in Psammomys obesus is related to β-cell apoptosis
5. Insulin resistance in the NIDDM model Psammomys obesus in the normoglycemic, normoinsulinemic state
6. Diabetes mellitus: A "thrifty" genotype rendered detrimental by "progress"
7. Diabetes induces selective alterations in the expression of protein kinase C isoforms in hepatocytes
8. Protein kinase C is increased in the liver of humans and rat with non-insulin-dependent diabetes mellitus: An alteration not due to hyperglycemia
9. Alterations in the expression and cellular localization of protein kinase C isozymes ε and θ are associated with insulin resistance in skeletal muscle of the high-fat-fed rat
10. Chronic activation of protein kinase C in soleus muscle and other tissues of insulin-resisant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats: A mechanism for inhibiting glycogen synthesis
11. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
12. Protein kinase C: Structure, function and regulation
13. The extended protein kinase C superfamily
14. Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase
15. Protein kinase C isoforms β1 and β2 inhibit the tyrosine kinase activity of the insulin receptor
16. Activation of protein kinase Cα inhibits signaling by members of the insulin receptor family
17. Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells
18. Rapid and long term effects of protein kinase C on receptor tyrosine kinase phosphorylation and degradation
19. The human insulin receptor cDNA
20. Differential utilization of ShcA tyrosine residues and functional domains in the transduction of epidermal growth factor-induced mitogen-activated protein kinase activation in 293T cells and nerve growth factor-induced neurite outgrowth in PC12 cells
21. High-efficiency transformation of mammalian cells by plasmid DNA
22. The human cytomegalovirus major immediate early promoter can be trans-activated by adenovirus early proteins
23. A microtiter well assay system to measure insulin activation of insulin receptor kinase in intact mononuclear cells: Decreased insulin effect in cells from patients with NIDDM
24. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia
25. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
26. Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats
27. Decreased expression of protein kinase C alpha, beta, and epsilon in soleus muscle of Zucker obese (fa/fa) rats
28. Ameloriation of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor
29. Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling
30. Protein kinase C (PKC) epsilon enhances the inhibitory effect of TNF alpha on insulin signaling in HEK293 cells
31. Tumor necrosis factor α inhibits signaling from the insulin receptor
32. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes
33. Hyperinsulinemia induces a reversible impairment in receptor function leading to diabetes in the sand rat model of non-insulin-dependent diabetes mellitus
34. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
35. Perspective: The insulin signaling system: A common link in the pathogenesis of type 2 diabetes