The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin

Molecular and Cellular Biology

Volumn 22, Issue 21, 2002, Pages 7428-7438

  McMahon, Lloyd P ^a   Choi, Kin M ^a   Lin, Tai An ^a   Abraham, Robert T ^a   Lawrence Jr , John C ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; FK 506 BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN SERINE THREONINE KINASE; RAPAMYCIN; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SELECTIVITY; ENZYME INHIBITOR INTERACTION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; TRANSLATION REGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIBIOTICS, ANTINEOPLASTIC; BINDING SITES; CARRIER PROTEINS; CELL LINE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KINETICS; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SERINE; SIROLIMUS; SUBSTRATE SPECIFICITY; THREONINE; TIME FACTORS; TRANSFECTION;

MAMMALIA;

EID: 0036837863     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.21.7428-7438.2002     Document Type: Article

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