Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast

Cancer Research

Volumn 59, Issue 9, 1999, Pages 2041-2044

  Tanaka, Takuji ^b   Kimura, Masashi ^a   Matsunaga, Kengo ^a   Fukada, Daizo ^a   Mori, Hideki ^a   Okano, Yukio ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN SERINE THREONINE KINASE;

ARTICLE; BREAST CARCINOMA; CANCER CLASSIFICATION; CARCINOGENESIS; CLINICAL ARTICLE; FEMALE; GENE AMPLIFICATION; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; PRIORITY JOURNAL;

EID: 0033135640     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Kinzler, K. W., and Vogelstein, B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature (Lond.), 386: 761-763, 1997.
2. Vogelstein, B., Fearon, E. R., Hamilton, S. R., Kern, S. E., Preisinger, A. C., Leppert, M., Nakamura, Y., White, R., Smits, A. M. M., and Bos, J. L. Genetic alterations during colorectal-tumor development. N. Engl. J. Med., 319: 525-532, 1988.
3. Shackney, S. E., and Shankey, T. V. Common patterns of genetic evolution in human solid tumors. Cytometry, 29: 1-27, 1997.
4. Hartwell, L. Defects in a cell cycle checkpoint may be responsible for genomic instability of cancer cells. Cell, 71: 543-546, 1992.
5. Loeb, L. A. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res., 51: 3075-3079, 1991.
6. Lengauer, C., Kinzler, K. W., and Vogelstein, B. Genetic instability in colorectal cancers. Nature (Lond.), 386: 623-627, 1997.
7. Bringuier, P. P., Bouvier, R., Berger, N., Piaton, E., Revillard, J. P., Perrin, P., and Devonec, M. DNA ploidy status and DNA content instability within single tumors in renal cell carcinoma. Cytometry, 14: 559-564, 1993.
8. Melchiorri, C., Chieco, P., Lisignoli, G., Marabini, A., and Orlandi, C. Ploidy disturbances as an early indicator of intrinsic malignancy in endometrial carcinoma. Cancer (Phila.), 72: 165-172, 1993.
9. Shackney, S. E., Smith, C. A., Miller, B. W., Burholt, D. R., Murtha, K., Giles, H. R., Ketterer, D. M., and Pollice, A. A. Model for the genetic evolution of human solid tumors. Cancer Res., 49: 3344-3354, 1989.
10. Pihan, G. A., Purohit, A., Wallace, J., Knecht, H., Woda, B., Quesenberry, P., and Doxsey, S. J. Centrosome defects and genetic instability in malignant tumors. Cancer Res., 58: 3974-3985, 1998.
11. Francisco, L., Wang, W., and Chan, C. S. Type 1 protein phosphatase acts in opposition to IpI1 protein kinase in regulating yeast chromosome segregation. Mol. Cell. Biol., 14: 4731-4740, 1994.
12. Glover, D. M., Leibowitz, M. H., McLean, D. A., and Parry, H. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell, 81: 95-105, 1995.
13. Chan, C. S., and Botstein, D. Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast. Genetics, 135: 677-691, 1993.
14. Kimura, M., Kotani, S., Hattori, T., Sumi, N., Yoshioka, T., Todokoro, K., and Okano, Y. Cell cycle-dependent expression and spindle localization of a novel human protein kinase, Aik, related to aurora of Drosophila and yeast IpI1. J. Biol. Chem., 272: 13766-123771, 1997.
15. Sen, S., Zhou, H., and White, R. A. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene, 14: 2195-2200, 1997.
16. Bischoff, J. R., Anderson, L., Zhu, Y., Mossie, K., Ng, L., Souza, B., Schryver, B., Flanagan, P., Clairvoyant, F., Ginther, C., Chan, C. S. M., Novotny, M., Slamon, D. J., and Plowman, G. D. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J., 17: 3052-3065, 1998.
17. Shindo, M., Nakano, H., Kuroyanagi, H., Shirasawa, T., Mihara, M., Gilbert, D. J., Jenkins, N. A., Copeland, N. G., Yagita, H., and Okumura, K. cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2. Biochem. Biophys. Res. Commun., 244: 285-292, 1998.
18. Niwa, H., Abe, K., Kunisada, T., and Yamamura, K. Cell-cycle-dependent expression of the STK-1 gene encoding a novel murine putative protein kinase. Gene (Amst.), 169: 197-201, 1996.
19. Yanai, A., Arama, E., Kilfin, G., and Motro, B. aykl, a novel mammalian gene related to Drosophila aurora centrosome separation kinase, is specifically expressed during meiosis. Oncogene, 14: 2943-2950, 1997.
20. Gopalan, G., Chan, C. S., and Donovan, P. J. A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators. J. Cell Biol., 138: 643-656, 1997.
21. Terada, Y., Tatsuka, M., Suzuki, F., Yasuda, Y., Fujita, S., and Otsu, M. AIM-1: a mammalian midbody-associated protein required for cytokinesis. EMBO J., 17: 667-676, 1997.
22. Kimura, M., Matsuda, Y., Yoshioka, T., Sumi, N., and Okano, Y. Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1. Cytogenet. Cell Genet., 82: 147-152, 1998.
23. Roghi, C., Giet, R., Uzbekov, R., Morin, N., Chartrain, I., Le Guellec, R., Couturier, A., Dor, M., Philippe, M., and Prigent, C. The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly. J. Cell Sci., 111: 557-572, 1998.
24. Kimura, M., Matsuda, Y., Yoshioka, T., and Okano Y. Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. J. Biol. Chem., 114: 7334-7340, 1999.
25. Bernard, M., Sanseau, P., Henry, C., Couturier, A., and Prigent, C. Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast IpI1 that maps on chromosome 19q13.3-ter. Genomics, 53: 406-409, 1998.
26. Zhou, H., Kuang, J., Zhong, L., Kuo, W., Gray, J. W., Sahin, A., Brinkley, B. R., and Sen, S. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet., 20: 189-193, 1998.
27. Kallioniemi, A., Kallioniemi, O-P., Piper, J., Tanner, M., Stokke, T., Chen, L., Smith, H. S., Pinkel, D., Gray, J. W., and Waldman, F. M. Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc. Natl. Acad. Sci. USA, 91: 2156-2160, 1994.
28. Iwabuchi, H., Sakamoto, M., Sakunaga, H., Ma, Y-Y., Carcangiu, M. L., Pinkel, D., Yang-Feng, T. L., and Gary, J. W. Genetic analysis of benign, low-grade, and high-grade ovarian tumors. Cancer Res, 55: 6172-6180, 1995.
29. Kallioniemi, A., Kallioniemi, O-P., Citro, G., Sauter, G., DeVries, S., Kerschmann, R., Caroll, P., and Waldman, F. Identification of gains and losses of DNA sequences in primary bladder cancer by comparative genomic hybridization. Genes Chromosomes Cancer, 12: 213-219, 1995.
30. Tanner, M. M., Tirkkonen, M., Kallioniemi, A., Collins, C., Stokke, T., Karhu, R., Kowbel, D., Shadravan, F., Hintz, M., Kuo, W-L., Waldman, F. M., Isola, J. J., Gray, J. W., and Kallioniemi, O-P. Increased copy number at 20q13 in breast cancer: defining the critical region and exclusion of candidate genes. Cancer Res., 54: 4257-4260, 1994.
31. Savelieva, E., Belair, C. D., Newton, M. A., DeVries, S., Gray, J. W., Waldman, F., and Reznikoff, C. A. 20q gain associates with immortalization: 20q13.2 amplification correlates with genome instability in human papillomavirus 16E7 transformed human uroepithelial cells. Oncogene, 14: 551-560, 1997.
32. Isola, J. J., Kallioniemi, O. P., Chu, L. W., Fuqua, S. A., Hilsenbeck, S. G., Osborne, C. K., and Waldman, F. M. Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer. Am. J. Pathol., 147: 905-911, 1995.
33. Kimura, M., Matsuda, Y., Eki, T., Yoshioka, T., Okumura, K., Hanaoka, F., and Okano, Y. Assignment of STK6 to human chromosome 20q13.2-q13.3 and a pseudogene STK6P to 1q41-42. Cytogenet. Cell Genet., 79: 201-203, 1997.
34. Hunter, T. Oncoprotein networks. Cell, 88: 333-346, 1997.
35. Elledge, S. J. Cell cycle checkpoints: preventing an identity crisis. Science (Washington DC), 274: 1664-1672, 1996.
36. Sherr, C. J. Cancer cell cycles. Science (Washington DC), 274: 1672-1677, 1996.
37. Tanner, M. M., Tirkkonen, M., Kallioniemi, A., Isola, J., Kuukasjarvi, T., Collins, C., Kowbel, D., Guan, X-Y., Trent, J., Gray, J. W., Meltzer, P., and Kallioniemi, O-P. Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer. Cancer Res., 56: 3441-3445, 1996.
38. Tanner, M. M., Tirkkonen, M., Kallioniemi, A., Holli, K., Collins, C., Kowbel, D., Gray, J. W., Kallioniemi, O-P., and Isola, J. Amplification of chromosomal region 20q13 in invasive breast cancer: prognostic implications. Clin. Cancer Res., 1: 1455-1461, 1995.
39. Alanen, K. A., Lintu, M., and Joensuu, H. Image cytometry of breast carcinomas that are DNA diploid by flow cytometry: time to revise the concept of DNA diploidy? Anal. Quant. Cytol. Histol., 20: 178-186, 1998.
40. Tatsuka, M., Katayama, H., Ota, T., Tanaka, T., Odashima, S., Suzuki, F., and Terada, Y. Multinuclearity and increased ploidy caused by overexpression of the aurora- and IpI1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res., 58: 4811-4816, 1998.