Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1

Molecular Biology of the Cell

Volumn 12, Issue 5, 2001, Pages 1315-1328

  Andreassen, P R ^a   Lohez, O D ^a   Lacroix, F B ^a   Margolis, R L ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN E; DIHYDROCYTOCHALASIN B; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ANEUPLOIDY; ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; CELL DAMAGE; CELL DIVISION; CELL TRANSFORMATION; CONTROLLED STUDY; GENE ACTIVITY; HUMAN; HUMAN CELL; MAMMAL CELL; MICROTUBULE; MITOSIS SPINDLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TETRAPLOIDY;

ANIMALIA; MAMMALIA;

EID: 0034767429     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.5.1315     Document Type: Article

References (52)

1. cdc2 inactibation and mitotic exit in mammalian cells
2. Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state
3. Inhibition of cytokinesis and altered contractile ring morphology induced by cytochalasins in synchronized PtK2 cells
4. Suppression of human colorectal carcinoma cell growth by wild-type p53
5. Enhanced phosphorylation of p53 by ATM in response to DNA damage
6. Changes in the subcellular localization of the replication initiation proteins and cell cycle proteins during G1- to S-phase transition in mammalian cells
7. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
8. Mutations of mitotic checkpoint genes in human cancers
9. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
10. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
11. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
12. Tumor suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
13. A p53-dependent mouse spindle checkpoint
14. Monoclonal antibodies to mitotic cells
15. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function
16. Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability
17. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors
18. Genetic instability of cancer cells is proportional to their degree of aneuploidy
19. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
20. Differential regulation of E2F transactivation by cyclin/cdk2 complexes
21. WAF1, a potential mediator of p53 tumor suppression
22. 17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus
23. Ploidy regulation of gene expression
24. Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase
25. Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal
26. Defects in a cell cycle checkpoint may be responsible for the genomic instablility in cancer cells
27. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice
28. Requirement of a centrosomal activity for cell cycle progression through G1 into S phase
29. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
30. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4
31. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle
32. Cell-line specific differences in the control of cell cycle progression in the absence of mitosis
33. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
34. Genetic instabilities in human cancers
35. Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells
36. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
37. Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: Retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery
38. Expression of Bcl-x and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage
39. Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice
40. Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts
41. Simian virus 40 large tumor antigen alone or two cooperating oncogenes convert REF52 cells to a state permissive for gene amplification
42. Progression to cancer in Barrett's esophagus is associated with genomic instability
43. Chromosome markers and progression in bladder cancer
44. Differences in mitotic control among mammalian cells
45. Model for the genetic evolution of human solid tumors
46. Identification of a minimal transforming domain of p53: Negative dominance through abrogation of sequence-specific DNA binding
47. Waf1/Cip1 inhibition of cyclin E and Cdk2 activity prevents endoreduplication after mitotic spindle disruption
48. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
49. Differential taxol-dependent arrest of transformed and non-transformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells
50. The cdk2 kinase is required for the G1-S transition in mammalian cells
51. Retinoblastoma protein switches the E2F site from positive to negative element
52. Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6