Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease

Biochemical Pharmacology

Volumn 66, Issue 8, 2003, Pages 1627-1634

  Eckert, Anne ^a   Keil, Uta ^a   Marques, Celio A ^a   Bonert, Astrid ^a   Frey, Claudia ^a   Schüssel, Katrin ^a   Müller, Walter E ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Amyloid; A ; AD; Alzheimer's disease; Amyloid beta; Amyloid precursor protein; APP; APP mutation; c Jun N terminal kinase; Caspases; COX; Cytochrome c oxidase; FAD; Familial Alzheimer's disease; JNK; Oxidative stress; Reactive oxygen species; ROS

Indexed keywords

AMYLOID BETA PROTEIN; CASPASE; REACTIVE OXYGEN METABOLITE;

ALZHEIMER DISEASE; APOPTOSIS; BIOACCUMULATION; CELL DEATH; CELL LOSS; CELL ULTRASTRUCTURE; CONFERENCE PAPER; FAMILIAL DISEASE; HUMAN; MITOCHONDRION; NERVE CELL; NERVE CELL DEGENERATION; NONHUMAN; OLIGOMERIZATION; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SYNAPSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; METABOLISM; PATHOLOGY; REVIEW;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; APOPTOSIS; HUMANS; MITOCHONDRIAL DISEASES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 0642375798     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00534-3     Document Type: Conference Paper

References (90)

1. Stock D., Gibbons C., Arechaga I., Leslie A.G., Walker J.E. The rotary mechanism of ATP synthase. Curr. Opin. Struct. Biol. 10:2000;672-679.
2. Reed J.C. Mechanisms of apoptosis. Am. J. Pathol. 157:2000;1415-1430.
3. Kroemer G., Dallaporta B., Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol. 60:1998;619-642.
4. Desagher S., Martinou J.C. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 10:2000;369-377.
5. Green D.R., Reed J.C. Mitochondria and apoptosis. Science. 281:1998;1309-1312.
6. Kroemer G., Reed J.C. Mitochondrial control of cell death. Nat. Med. 6:2000;513-519.
7. Wadia J.S., Chalmers-Redman R.M.E., Ju W.J.H., Carlile G.W., Phillips J.L., Fraser A.D., Tatton W.G. Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl. J. Neurosci. 18:1998;932-947.
8. Nicholls D.G., Budd S.L. Mitochondria and neuronal survival. Physiol. Rev. 80:2000;315-360.
9. Reed J.C., Jurgensmeier J.M., Matsuyama S. Bcl-2 family proteins and mitochondria. Biochim. Biophys. Acta. 1366:1998;127-137.
10. Brown G.C. Cell biology. NO says yes to mitochondria. Science. 299:2003;838-839.
11. Orth M., Schapira A.H. Mitochondria and degenerative disorders. Am. J. Med. Genet. 106:2001;27-36.
12. Hirai K., Aliev G., Nunomura A., Fujioka H., Russell R.L., Atwood C.S., Johnson A.B., Kress Y., Vinters H.V., Tabaton M., Shimohama S., Cash A.D., Siedlak S.L., Harris P.L., Jones P.K., Petersen R.B., Perry G., Smith M.A. Mitochondrial abnormalities in Alzheimer's disease. J. Neurosci. 21:2001;3017-3023.
13. Harman D. Free radical theory of aging. Mutat. Res. 275:1992;257-266.
14. Castellani R., Hirai K., Aliev G., Drew K.L., Nunomura A., Takeda A., Cash A.D., Obrenovich M.E., Perry G., Smith M.A. Role of mitochondrial dysfunction in Alzheimer's disease. J. Neurosci. Res. 70:2002;357-360.
15. Mattson M.P., Pedersen W.A., Duan W., Culmsee C., Camandola S. Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases. Ann. N.Y. Acad. Sci. 893:1999;154-175.
16. Blass J.P., Gibson G.E. The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease. Rev. Neurol. (Paris). 147:1991;513-525.
17. Mattson M.P., Liu D. Energetics and oxidative stress in synaptic plasticity and neurodegenerative disorders. Neuromol. Med. 2:2002;215-231.
18. Beal M.F. Mitochondria, free radicals, and neurodegeneration. Curr. Opin. Neurobiol. 6:1996;661-666.
19. Christen Y. Oxidative stress and Alzheimer disease. Am. J. Clin. Nutr. 71:2000;621S-629S.
20. Smith M.A., Rottkamp C.A., Nunomura A., Raina A.K., Perry G. Oxidative stress in Alzheimer's disease. Biochim. Biophys. Acta. 1502:2000;139-144.
21. Munch G., Thome J., Foley P., Schinzel R., Riederer P. Advanced glycation endproducts in ageing and Alzheimer's disease. Brain Res. Brain Res. Rev. 23:1997;134-143.
22. Munch G., Gerlach M., Sian J., Wong A., Riederer P. Advanced glycation end products in neurodegeneration: more than early markers of oxidative stress? Ann. Neurol. 44:1998;S85-S88.
23. Nunomura A., Perry G., Aliev G., Hirai K., Takeda A., Balraj E.K., Jones P.K., Ghanbari H., Wataya T., Shimohama S., Chiba S., Atwood C.S., Petersen R.B., Smith M.A. Oxidative damage is the earliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol. 60:2001;759-767.
24. Lyras L., Cairns N.J., Jenner A., Jenner P., Halliwell B. An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease. J. Neurochem. 68:1997;2061-2069.
25. Dei R., Takeda A., Niwa H., Li M., Nakagomi Y., Watanabe M., Inagaki T., Washimi Y., Yasuda Y., Horie K., Miyata T., Sobue G. Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's disease. Acta Neuropathol. (Berl.). 104:2002;113-122.
26. Schüssel K., Leutner S., Cairns N.J., Eckert A., Müller W.E. Increased activities of antioxidant enzymes in brains from Alzheimer's disease patients. Pharmacopsychiatry. 34:2001;200.
27. Wong A., Luth H.J., Deuther-Conrad W., Dukic-Stefanovic S., Gasic-Milenkovic J., Arendt T., Munch G. Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer's disease. Brain Res. 920:2001;32-40.
28. Huang H.M., Zhang H., Xu H., Gibson G.E. Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation. Biochim. Biophys. Acta. 1637:2003;119-126.
29. Gibson G.E., Park L.C., Sheu K.F., Blass J.P., Calingasan N.Y. The alpha-ketoglutarate dehydrogenase complex in neurodegeneration. Neurochem. Int. 36:2000;97-112.
30. Gibson G.E. Interactions of oxidative stress with cellular calcium dynamics and glucose metabolism in Alzheimer's disease(1,2). Free Radic. Biol. Med. 12(32):2002;1061-1070.
31. Maurer I., Zierz S., Moller H.J. A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients. Neurobiol. Aging. 21:2000;455-462.
32. Kish S.J., Mastrogiacomo F., Guttman M., Furukawa Y., Taanman J.W., Dozic S., Pandolfo M., Lamarche J., DiStefano L., Chang L.J. Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change? J. Neurochem. 72:1999;700-707.
33. 0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease. Neurobiol. Aging. 23:2002;371-376.
34. Ojaimi J., Masters C.L., McLean C., Opeskin K., McKelvie P., Byrne E. Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease. Ann. Neurol. 46:1999;656-660.
35. Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H., Coulson A.R., Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H., Smith A.J., Staden R., Young I.G. Sequence and organization of the human mitochondrial genome. Nature. 290:1981;457-465.
36. Wallace D.C. Mitochondrial DNA mutations in diseases of energy metabolism. J. Bioenerg. Biomembr. 26:1994;241-250.
37. Wallace D.C. Mitochondrial diseases in man and mouse. Science. 283:1999;1482-1488.
38. Michikawa Y., Mazzucchelli F., Bresolin N., Scarlato G., Attardi G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science. 286:1999;774-779.
39. Chandrasekaran K., Giordano T., Brady D.R., Stoll J., Martin L.J., Rapoport S.I. Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease. Brain Res. Mol. Brain Res. 24:1994;336-340.
40. Chang S.W., Zhang D., Chung H.D., Zassenhaus H.P. The frequency of point mutations in mitochondrial DNA is elevated in the Alzheimer's brain. Biochem. Biophys. Res. Commun. 273:2000;203-208.
41. Lin M.T., Simon D.K., Ahn C.H., Kim L.M., Beal M.F. High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum. Mol. Genet. 11:2002;133-145.
42. Fukuyama R., Hatanpaa K., Rapoport S.I., Chandrasekaran K. Gene expression of ND4, a subunit of complex I of oxidative phosphorylation in mitochondria, is decreased in temporal cortex of brains of Alzheimer's disease patients. Brain Res. 713:1996;290-293.
43. Hutchin T., Cortopassi G. A mitochondrial DNA clone is associated with increased risk for Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 92:1995;6892-6895.
44. Lin F.H., Lin R., Wisniewski H.M., Hwang Y.W., Grundke-Iqbal I., Healy-Louie G., Iqbal K. Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains. Biochem. Biophys. Res. Commun. 182:1992;238-246.
45. Simonian N.A., Hyman B.T. Functional alterations in Alzheimer's disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation. J. Neuropathol. Exp. Neurol. 53:1994;508-512.
46. Davis R.E., Miller S., Herrnstadt C., Ghosh S.S., Fahy E., Shinobu L.A., Galasko D., Thal L.J., Beal M.F., Howell N., Parker W.D. Jr. Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 94:1997;4526-4531.
47. Sheehan J.P., Swerdlow R.H., Miller S.W., Davis R.E., Parks J.K., Parker W.D. Jr., Tuttle J.B. Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease. J. Neurosci. 17:1997;4612-4622.
48. Selkoe D.J. Alzheimer's disease is a synaptic failure. Science. 298:2002;789-791.
49. Pike C.J., Walencewicz A.J., Glabe C.G., Cotman C.W. Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures. Eur. J. Pharmacol. 207:1991;367-368.
50. Hartmann T. Intracellular biology of Alzheimer's disease amyloid beta peptide. Eur. Arch. Psychiatry Clin. Neurosci. 249:1999;291-298.
51. Forloni G., Chiesa R., Smiroldo S., Verga L., Salmona M., Tagliavini F., Angeretti N. Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35. Neuroreport. 4:1993;523-526.
52. LaFerla F.M., Tinkle B.T., Bieberich C.J., Haudenschild C.C., Jay G. The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat. Genet. 9:1995;21-30.
53. Loo D.T., Copani A., Pike C.J., Whittemore E.R., Walencewicz A.J., Cotman C.W. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. U.S.A. 90:1993;7951-7955.
54. Bruce-Keller A.J., Begley J.G., Fu W., Butterfield D.A., Bredesen D.E., Hutchins J.B., Hensley K., Mattson M.P. Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide. J. Neurochem. 70:1998;31-39.
55. Mattson M.P., Partin J., Begley J.G. Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites. Brain Res. 807:1998;167-176.
56. Su J.H., Nichol K.E., Sitch T., Sheu P., Chubb C., Miller B.L., Tomaselli K.J., Kim R.C., Cotman C.W. DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia. Exp. Neurol. 163:2000;9-19.
57. Su J.H., Satou T., Anderson A.J., Cotman C.W. Up-regulation of Bcl-2 is associated with neuronal DNA damage in Alzheimer's disease. Neuroreport. 7:1996;437-440.
58. Rohn T.T., Head E., Nesse W.H., Cotman C.W., Cribbs D.H. Activation of caspase-8 in the Alzheimer's disease brain. Neurobiol. Dis. 8:2001;1006-1016.
59. Rohn T.T., Rissman R.A., Davis M.C., Kim Y.E., Cotman C.W., Head E. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol. Dis. 11:2002;341-354.
60. Butterfield D.A., Hensley K., Harris M., Mattson M., Carney J. Beta-amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease. Biochem. Biophys. Res. Commun. 200:1994;710-715.
61. Misonou H., Morishima-Kawashima M., Ihara Y. Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. Biochemistry. 39:2000;6951-6959.
62. Abe K., Saito H. Both oxidative stress-dependent and independent effects of amyloid beta protein are detected by 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) reduction assay. Brain Res. 830:1999;146-154.
63. Muller W.E., Koch S., Eckert A., Hartmann H., Scheuer K. Beta-amyloid peptide decreases membrane fluidity. Brain Res. 674:1995;133-136.
64. Eckert A., Keil U., Kressmann S., Schindowski K., Leutner S., Leutz S., Müller W.E. Effects of EGb 761 Ginkgo biloba extract on mitochondrial function and oxidative stress. Pharmacopsychiatry. 36(Suppl. 1):2003;S15-S23.
65. Casley C.S., Canevari L., Land J.M., Clark J.B., Sharpe M.A. Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J. Neurochem. 80:2002;91-100.
66. Parks J.K., Smith T.S., Trimmer P.A., Bennett J.P. Jr., Parker W.D. Jr. Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro. J. Neurochem. 76:2001;1050-1056.
67. Troy C.M., Rabacchi S.A., Xu Z., Maroney A.C., Connors T.J., Shelanski M.L., Greene L.A. Beta-amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. J. Neurochem. 77:2001;157-164.
68. Morishima Y., Gotoh Y., Zieg J., Barrett T., Takano H., Flavell R., Davis R.J., Shirasaki Y., Greenberg M.E. Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. J. Neurosci. 21:2001;7551-7560.
69. Yin K.J., Lee J.M., Chen S.D., Xu J., Hsu C.Y. Amyloid-beta induces Smac release via AP-1/Bim activation in cerebral endothelial cells. J. Neurosci. 22:2002;9764-9770.
70. Guo Q., Fu W., Holtsberg F.W., Steiner S.M., Mattson M.P. Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations. J. Neurosci. Res. 56:1999;457-470.
71. Passer B.J., Pellegrini L., Vito P., Ganjei J.K., D'Adamio L. Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death. J. Biol. Chem. 274:1999;24007-24013.
72. Mattson M.P., Chan S.L., Camandola S. Presenilin mutations and calcium signaling defects in the nervous and immune systems. Bioessays. 23:2001;733-744.
73. Czech C., Tremp G., Pradier L. Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms. Prog. Neurobiol. 60:2000;363-384.
74. Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81:2001;741-766.
75. Guo Q., Sopher B.L., Furukawa K., Pham D.G., Robinson N., Martin G.M., Mattson M.P. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. J. Neurosci. 17:1997;4212-4222.
76. Eckert A., Steiner B., Marques C., Leutz S., Romig H., Haass C., Muller W.E. Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation. J. Neurosci. Res. 64:2001;183-192.
77. Eckert A., Schindowski K., Leutner S., Luckhaus C., Touchet N., Czech C., Muller W.E. Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice. Neurobiol. Dis. 8:2001;331-342.
78. Guo Q., Sebastian L., Sopher B.L., Miller M.W., Ware C.B., Martin G.M., Mattson M.P. Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation. J. Neurochem. 72:1999;1019-1029.
79. Guo Q., Fu W., Sopher B.L., Miller M.W., Ware C.B., Martin G.M., Mattson M.P. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat. Med. 5:1999;101-106.
80. Parshad R.P., Sanford K.K., Price F.M., Melnick L.K., Nee L.E., Schapiro M.B., Tarone R.E., Robbins J.H. Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture. Proc. Natl. Acad. Sci. U.S.A. 93:1996;5146-5150.
81. Eckert A., Cotman C.W., Zerfass R., Hennerici M., Müller W.E. Enhanced vulnerability to apoptotic cell death in sporadic Alzheimer's disease. Neuroreport. 9:1998;2443-2446.
82. Eckert A., Oster M., Zerfass R., Hennerici M., Muller W.E. Elevated levels of fragmented DNA nucleosomes in native and activated lymphocytes indicate an enhanced sensitivity to apoptosis in sporadic Alzheimer's disease. Specific differences to vascular dementia. Dement. Geriatr. Cogn. Disord. 12:2001;98-105.
83. Gibson G.E., Zhang H., Sheu K.R., Park L.C. Differential alterations in antioxidant capacity in cells from alzheimer patients. Biochim. Biophys. Acta. 1502:2000;319-329.
84. Mecocci P., Polidori M.C., Ingegni T., Cherubini A., Chionne F., Cecchetti R., Senin U. Oxidative damage to DNA in lymphocytes from AD patients. Neurology. 51:1998;1014-1017.
85. Leutz S., Steiner B., Marques M.A., Haass C., Müller W.E., Eckert A. Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death. J. Mol. Neurosci. 18:2002;189-201.
86. Keil U., Steiner B., Haass C., Müller W.E., Eckert A. Mitochondrial dysfunction in oxidative stress-induced cell death of PC12 cells bearing APP mutations. Soc. Neurosci. 28:2002;193.
87. Marques C.A., Steiner B., Haass C., Müller W.E., Eckert A. The Swedish APP mutation leads to enhanced activation of different cell death mechanisms in response to oxidative stress. Soc. Neurosci. 28:2002;193.
88. Marques C.A., Keil U., Bonert A., Steiner B., Haass C., Müller W.E., Eckert A. Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation. J. Biol. Chem. 278:2003;28294-28302.
89. Kumar S., Vaux D.L. Apoptosis. A cinderella caspase takes center stage. Science. 297:2002;1290-1291.
90. Hager K., Marahrens A., Kenklies M., Riederer P., Munch G. Alpha-lipoic acid as a new treatment for Alzheimer type dementia. Arch. Gerontol. Geriatr. 32:2001;275-282.