Neurotoxic mechanisms caused by the alzheimer's disease-linked Swedish amyloid precursor protein. Mutation oxidative stress, caspases, and the JNK pathway

Journal of Biological Chemistry

Volumn 278, Issue 30, 2003, Pages 28294-28302

  Marques, Celio A ^a   Keil, Uta ^a   Bonert, Astrid ^a   Steiner, Barbara ^a   Haass, Christian ^b   Müller, Walter E ^a   Eckert, Anne ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENES; NEUROLOGY; PROTEINS;

NEURONS;

BIOCHEMISTRY;

AMYLOID PRECURSOR PROTEIN; CASPASE; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; HYDROGEN PEROXIDE; PRESENILIN 1; PRESENILIN 2; STRESS ACTIVATED PROTEIN KINASE;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HUMAN CELL; NERVE DEGENERATION; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASE 9; CASPASES; CELL DEATH; CELL LINE; CYTOCHROME C GROUP; CYTOSOL; FLOW CYTOMETRY; HUMANS; HYDROGEN PEROXIDE; IMMUNOBLOTTING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MODELS, BIOLOGICAL; MUTATION; NEURONS; OXIDATIVE STRESS; PC12 CELLS; PRESENILIN-1; PRESENILIN-2; RATS; TIME FACTORS; TRANSFECTION;

EID: 0042847291     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212265200     Document Type: Article

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