Interactions of oxidative stress with cellular calcium dynamics and glucose metabolism in Alzheimer's disease

Free Radical Biology and Medicine

Volumn 32, Issue 11, 2002, Pages 1061-1070

  Gibson, Gary E ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein APP; Amyloid beta peptide A ; Calcium; Free radicals; Hydrogen peroxide; Oxidative stress; Reactive oxygen species; Ketoglutarate dehydrogenase complex

Indexed keywords

ACROLEIN; APOLIPOPROTEIN E; BOMBESIN; BRADYKININ; CALCIUM; CYTOCHROME C OXIDASE; GLUCOSE; OXOGLUTARATE DEHYDROGENASE; PRESENILIN 1; PYRUVATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; TAU PROTEIN; TRANSKETOLASE;

ALLELE; ALZHEIMER DISEASE; BRAIN DYSFUNCTION; BRAIN FUNCTION; BRAIN METABOLISM; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; DYNAMICS; ENERGY METABOLISM; ENZYME ACTIVITY; FIBROBLAST; GENE MUTATION; GENETIC DISORDER; GENOTYPE; GLUCOSE METABOLISM; HUMAN; MENTAL FUNCTION; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; METABOLISM; PATHOLOGY;

ALZHEIMER DISEASE; CALCIUM; ENERGY METABOLISM; GLUCOSE; HUMANS; OXIDATIVE STRESS;

EID: 0036591850     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)00802-X     Document Type: Article

References (86)

1. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
2. Diagnosis of Alzheimer's disease
3. Neuroanatomical evidence for a cholinergic deficit in Alzheimer's disease
4. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease
5. Protein-bound acrolein: A novel marker of oxidative stress in Alzheimer's disease
6. Prediction of cognitive decline in normal elderly subjects with 2-fluoro-2-deoxyglucose/positon-emission tomography
7. Hippocampal formation glucose metabolism and volume losses in MCI and AD
8. Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis
9. Brain dysfunction in mild to moderate hypoxia
10. Thiamine-dependent enzyme changes in the brains of alcoholics: Relationship to the Wernicke-Korsakoff syndrome
11. Role of calcium ions in regulation of mammalian intramitochondrial metabolism
12. Selective changes in cell bodies and growth cones of nerve growth factor-differentiated PC12 cells induced by chemical hypoxia
13. The neurometabolic landscape of cognitive decline: In vivo studies with positron emission tomography in Alzheimer's disease
14. Cerebral metabolic response to passive audiovisual stimulation in patients with Alzheimer's disease and healthy volunteers assessed by PET
15. Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease
16. Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment
17. The alpha-ketoglutarate dehydrogenase complex in neurodegeneration
18. Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease
19. Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation
20. Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype
21. Downregulation of oxidative phosphorylation in Alzheimer disease: Loss of cytochrome oxidase subunit mRNA in the hippocampus and entorhinal cortex
22. Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease
23. Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease
24. Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia
25. Effects of Ginkgo biloba (EGb761) on metabolism of reactive oxygen species in fibroblasts from Alzheimer's Disease patients and controls
26. Oxidative alterations in Alzheimer's disease
27. Oxidative stress in Alzheimer's disease
28. Protein oxidation in the brain in Alzheimer's disease
29. An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease
30. Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease
31. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease
32. Widespread peroxynitrite-mediated damage in Alzheimer's disease
33. Oxidative damage is the earliest event in Alzheimer disease
34. Redox-active iron mediates amyloid-beta toxicity
35. The use of cultured fibroblasts in elucidating the pathophysiology and diagnosis of Alzheimer's disease
36. Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease
37. Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors
38. Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits
39. Abnormalities in Alzheimer's disease fibroblasts bearing the APP670/671 mutation
40. Differential alterations in antioxidant capacity in cells from Alzheimer patients
41. Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease
42. Altered calcium uptake in cultured skin fibroblasts from patients with Alzheimer's disease
43. Calcium stores in cultured fibroblasts and their changes with Alzheimer's disease
44. Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families
45. Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease
46. Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice
47. Presenilin-mediated modulation of capacitative calcium entry
48. Calcium responses in human fibroblasts: A diagnostic molecular profile for Alzheimer's disease
49. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide
50. Oxidative stress causes Alzheimer's Disease like changes in internal calcium stores and a key mitochondrial enzyme
51. Oxidative stress produces Alzheimer-like modifications in calcium homeostasis and mitochondrial enzymes
52. Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal
53. α-Ketoglutarate dehydrogenase and oxidative stress. International Society for Neurochemistry
54. Depolarization of in situ mitochondria due to hydrogen peroxide-induced oxidative stress in nerve terminals: Inhibition of alpha-ketoglutarate dehydrogenase
55. Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production
56. Involvement of oxidative stress on the impairment of energy metabolism induced by A beta peptides on PC12 cells: Protection by antioxidants
57. Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death
58. Nontoxic amyloid beta peptide 1-42 suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer's disease
59. β-Amyloid inhibits mitohondrial cytochrome oxidase and exacerbates nitric oxide toxicity: Implications for Alzheimer's disease
60. Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's abeta(1-2) and abeta(25-35)
61. Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity
62. Hydrogen peroxide mediates amyloid beta protein toxicity
63. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
64. Beta-amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation
65. Amyloid beta peptides mediate hypoxic augmentation of Ca(2+) channels
66. Intracellular calcium changes in neuronal cells induced by Alzheimer's beta-amyloid protein are blocked by estradiol and cholesterol
67. Hypoxic enhancement of quantal catecholamine secretion. Evidence for the involvement of amyloid beta-peptides
68. Alzheimer-type pathology in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)
69. Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells
70. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative
71. Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation
72. Oxidative stress induces intracellular accumulation of amyloid beta- protein (Abeta) in human neuroblastoma cells
73. N-acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: Effects on beta-amyloid secretion and tau phosphorylation
74. Mercury induces cell cytotoxicity and oxidative stress and increases beta-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells
75. The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells
76. Neurofibrillary tangles in chronic alcoholics
77. Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF
78. Induction of Alzheimer Antigens by an uncoupler of oxidative phosphorylation
79. Oxidative regulation of fatty acid-induced tau polymerization
80. Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits
81. The role of the cholinergic system in thiamin deficiency
82. 3,4-diaminopyridine alters acetylcholine metabolism and behavior during hypoxia
83. Glucose enhancement of memory in patients with probable senile dementia of the Alzheimer's type