메뉴 건너뛰기




Volumn 22, Issue 22, 2002, Pages 9764-9770

Amyloid-β induces Smac release via AP-1/Bim activation in cerebral endothelial cells

Author keywords

Alzheimer's disease; Amyloid peptide (A ); AP 1; BH3 only family; Cell death; Cerebral endothelial cells; Smac; XIAP

Indexed keywords

AMYLOID BETA PROTEIN; ANTISENSE OLIGONUCLEOTIDE; BIM PROTEIN; CASPASE; CURCUMIN; ENZYME ACTIVATOR; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG;

EID: 0037112194     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-22-09764.2002     Document Type: Article
Times cited : (107)

References (72)
  • 1
    • 0035803568 scopus 로고    scopus 로고
    • Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2
    • Adrain C, Creagh EM, Martin SJ (2001) Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. EMBO J 20:6627-6636.
    • (2001) EMBO J , vol.20 , pp. 6627-6636
    • Adrain, C.1    Creagh, E.M.2    Martin, S.J.3
  • 2
    • 0027283310 scopus 로고
    • Expression of c-fos and c-jun family genes after focal cerebral ischemia
    • An G, Lin TN, Liu JS, Xue JJ, He YY, Hsu CY (1993) Expression of c-fos and c-jun family genes after focal cerebral ischemia. Ann Neurol 33:457-464.
    • (1993) Ann Neurol , vol.33 , pp. 457-464
    • An, G.1    Lin, T.N.2    Liu, J.S.3    Xue, J.J.4    He, Y.Y.5    Hsu, C.Y.6
  • 3
    • 0032910169 scopus 로고    scopus 로고
    • Apoptosis control by death and decoy receptors
    • Ashkenazi A, Dixit VM (1999) Apoptosis control by death and decoy receptors. Curr Opin Cell Biol 11:255-260.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 255-260
    • Ashkenazi, A.1    Dixit, V.M.2
  • 4
    • 0025828493 scopus 로고
    • Transcriptional control by nuclear receptors
    • Beato M (1991) Transcriptional control by nuclear receptors. FASEB J 5:2044-2051.
    • (1991) FASEB J , vol.5 , pp. 2044-2051
    • Beato, M.1
  • 5
    • 0028233494 scopus 로고
    • Hydrogen peroxide mediates amyloid beta protein toxicity
    • Behl C, Davis JB, Lesley R, Schubert D (1994) Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77:817-827.
    • (1994) Cell , vol.77 , pp. 817-827
    • Behl, C.1    Davis, J.B.2    Lesley, R.3    Schubert, D.4
  • 6
    • 0031004788 scopus 로고    scopus 로고
    • Amyloid beta-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells
    • Blanc EM, Toborek M, Mark RJ, Hennig B, Mattson MP (1997) Amyloid beta-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells. J Neurochem 68:1870-1881.
    • (1997) J Neurochem , vol.68 , pp. 1870-1881
    • Blanc, E.M.1    Toborek, M.2    Mark, R.J.3    Hennig, B.4    Mattson, M.P.5
  • 7
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F, Adams JM, Strasser A (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286:1735-1738.
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1    Metcalf, D.2    Huang, D.C.3    Tarlinton, D.M.4    Kay, T.W.5    Kontgen, F.6    Adams, J.M.7    Strasser, A.8
  • 8
    • 0035019371 scopus 로고    scopus 로고
    • CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis
    • Bozyczko-Coyne D, O'Kane TM, Wu ZL, Dobrzanski P, Murthy S, Vaught JL, Scott RW (2001) CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis. J Neurochem 77:849-863.
    • (2001) J Neurochem , vol.77 , pp. 849-863
    • Bozyczko-Coyne, D.1    O'Kane, T.M.2    Wu, Z.L.3    Dobrzanski, P.4    Murthy, S.5    Vaught, J.L.6    Scott, R.W.7
  • 9
    • 0034630330 scopus 로고    scopus 로고
    • Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis
    • Bratton SB, MacFarlane M, Cain K, Cohen GM (2000) Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis. Exp Cell Res 256:27-33.
    • (2000) Exp Cell Res , vol.256 , pp. 27-33
    • Bratton, S.B.1    MacFarlane, M.2    Cain, K.3    Cohen, G.M.4
  • 10
    • 0035879072 scopus 로고    scopus 로고
    • Spontaneous changes in mitochondrial membrane potential in cultured neurons
    • Buckman JF, Reynolds IJ (2001) Spontaneous changes in mitochondrial membrane potential in cultured neurons. J Neurosci 21:5054-5065.
    • (2001) J Neurosci , vol.21 , pp. 5054-5065
    • Buckman, J.F.1    Reynolds, I.J.2
  • 12
    • 0033557658 scopus 로고    scopus 로고
    • Suppression of post-ischemic hippocampal nerve growth factor expression by a c-fos antisense oligode-oxynucleotide
    • Cui JK, Hsu CY, Liu PK (1999) Suppression of post-ischemic hippocampal nerve growth factor expression by a c-fos antisense oligode-oxynucleotide. J Neurosci 19:1335-1344.
    • (1999) J Neurosci , vol.19 , pp. 1335-1344
    • Cui, J.K.1    Hsu, C.Y.2    Liu, P.K.3
  • 13
    • 0023798751 scopus 로고
    • Fos and Jun: The AP-1 connection
    • Curran T, Franza Jr BR (1988) Fos and Jun: The AP-1 connection. Cell 55:395-397.
    • (1988) Cell , vol.55 , pp. 395-397
    • Curran, T.1    Franza B.R., Jr.2
  • 14
    • 0030513849 scopus 로고    scopus 로고
    • Oxidative mechanisms in beta-amyloid cytotoxicity
    • Davis JB (1996) Oxidative mechanisms in beta-amyloid cytotoxicity. Neurodegeneration 5:441-444.
    • (1996) Neurodegeneration , vol.5 , pp. 441-444
    • Davis, J.B.1
  • 15
    • 0036141029 scopus 로고    scopus 로고
    • TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO
    • Deng Y, Lin Y, Wu X (2002) TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. Genes Dev 16:33-45.
    • (2002) Genes Dev , vol.16 , pp. 33-45
    • Deng, Y.1    Lin, Y.2    Wu, X.3
  • 16
    • 0033082995 scopus 로고    scopus 로고
    • IAP family proteins - Suppressors of apoptosis
    • Deveraux QL, Reed JC (1999) IAP family proteins - Suppressors of apoptosis. Genes Dev 13:239-252.
    • (1999) Genes Dev , vol.13 , pp. 239-252
    • Deveraux, Q.L.1    Reed, J.C.2
  • 17
    • 0030810926 scopus 로고    scopus 로고
    • X-linked IAP is a direct inhibitor of cell-death proteases
    • Deveraux QL, Takahashi R, Salvesen GS, Reed JC (1997) X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388:300-304.
    • (1997) Nature , vol.388 , pp. 300-304
    • Deveraux, Q.L.1    Takahashi, R.2    Salvesen, G.S.3    Reed, J.C.4
  • 19
    • 0034609737 scopus 로고    scopus 로고
    • Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
    • Dijkers PF, Medema RH, Lammers JW, Koenderman L, Coffer PJ (2000) Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 10:1201-1204.
    • (2000) Curr Biol , vol.10 , pp. 1201-1204
    • Dijkers, P.F.1    Medema, R.H.2    Lammers, J.W.3    Koenderman, L.4    Coffer, P.J.5
  • 20
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    • Du C, Fang M, Li Y, Li L, Wang X (2000) Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102:33-42.
    • (2000) Cell , vol.102 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3    Li, L.4    Wang, X.5
  • 21
    • 0037018277 scopus 로고    scopus 로고
    • Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression
    • Fulda S, Meyer E, Debatin KM (2002) Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression. Oncogene 21:2283-2294.
    • (2002) Oncogene , vol.21 , pp. 2283-2294
    • Fulda, S.1    Meyer, E.2    Debatin, K.M.3
  • 22
    • 0021572660 scopus 로고
    • The amyloid deposits in Alzheimer's disease: Their nature and pathogenesis
    • Glenner GG, Wong CW, Quaranta V, Eanes ED (1984) The amyloid deposits in Alzheimer's disease: Their nature and pathogenesis. Appl Pathol 2:357-369.
    • (1984) Appl Pathol , vol.2 , pp. 357-369
    • Glenner, G.G.1    Wong, C.W.2    Quaranta, V.3    Eanes, E.D.4
  • 23
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC (1998) Mitochondria and apoptosis. Science 281:1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 24
    • 0033534446 scopus 로고    scopus 로고
    • Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death
    • Gross A, Yin XM, Wang K, Wei MC, Jockel J, Milliman C, Erdjument-Bromage H, Tempst P, Korsmeyer SJ (1999) Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem 274:1156-1163.
    • (1999) J Biol Chem , vol.274 , pp. 1156-1163
    • Gross, A.1    Yin, X.M.2    Wang, K.3    Wei, M.C.4    Jockel, J.5    Milliman, C.6    Erdjument-Bromage, H.7    Tempst, P.8    Korsmeyer, S.J.9
  • 25
    • 0028908516 scopus 로고
    • Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons
    • Harris ME, Hensley K, Butterfield DA, Leedle RA, Carney JM (1995a) Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons. Exp Neurol 131:193-202.
    • (1995) Exp Neurol , vol.131 , pp. 193-202
    • Harris, M.E.1    Hensley, K.2    Butterfield, D.A.3    Leedle, R.A.4    Carney, J.M.5
  • 27
    • 0031461944 scopus 로고    scopus 로고
    • Fragments of amyloid beta induce apoptosis in vascular endothelial cells
    • Hase M, Araki S, Havashi H (1997) Fragments of amyloid beta induce apoptosis in vascular endothelial cells. Endothelium 5:221-229.
    • (1997) Endothelium , vol.5 , pp. 221-229
    • Hase, M.1    Araki, S.2    Havashi, H.3
  • 28
    • 0033635733 scopus 로고    scopus 로고
    • BH3-only proteins - Essential initiators of apoptotic cell death
    • Huang DC, Strasser A (2000) BH3-only proteins - Essential initiators of apoptotic cell death. Cell 103:839-842.
    • (2000) Cell , vol.103 , pp. 839-842
    • Huang, D.C.1    Strasser, A.2
  • 29
    • 0033583218 scopus 로고    scopus 로고
    • The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein
    • Imaizumi K, Morihara T, Mori Y, Katayama T, Tsuda M, Furuyama T, Wanaka A, Takeda M, Tohyama M (1999) The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein. J Biol Chem 274:7975-7981.
    • (1999) J Biol Chem , vol.274 , pp. 7975-7981
    • Imaizumi, K.1    Morihara, T.2    Mori, Y.3    Katayama, T.4    Tsuda, M.5    Furuyama, T.6    Wanaka, A.7    Takeda, M.8    Tohyama, M.9
  • 31
    • 0032146987 scopus 로고    scopus 로고
    • Bcl-2-family proteins: The role of the BH3 domain in apoptosis
    • Kelekar A, Thompson CB (1998) Bcl-2-family proteins: The role of the BH3 domain in apoptosis. Trends Cell Biol 8:324-330.
    • (1998) Trends Cell Biol , vol.8 , pp. 324-330
    • Kelekar, A.1    Thompson, C.B.2
  • 32
    • 0026560009 scopus 로고
    • Regulation of jun-B messenger RNA and AP-1 activity by light and a circadian clock
    • Kornhauser JM, Nelson DE, Mayo KE, Takahashi JS (1992) Regulation of jun-B messenger RNA and AP-1 activity by light and a circadian clock. Science 255:1581-1584.
    • (1992) Science , vol.255 , pp. 1581-1584
    • Kornhauser, J.M.1    Nelson, D.E.2    Mayo, K.E.3    Takahashi, J.S.4
  • 33
    • 0021751120 scopus 로고
    • Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein
    • Kruijer W, Cooper JA, Hunter T, Verma IM (1984) Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature 312:711-716.
    • (1984) Nature , vol.312 , pp. 711-716
    • Kruijer, W.1    Cooper, J.A.2    Hunter, T.3    Verma, I.M.4
  • 34
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li H, Zhu H, Xu CJ, Yuan J (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491-501.
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 35
    • 0035811496 scopus 로고    scopus 로고
    • Endonuclease G is an apoptotic DNase when released from mitochondria
    • Li LY, Luo X, Wang X (2001) Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412:95-99.
    • (2001) Nature , vol.412 , pp. 95-99
    • Li, L.Y.1    Luo, X.2    Wang, X.3
  • 36
    • 0028170006 scopus 로고
    • Suppression of ischemia-induced fos expression and AP-1 activity by an antisense oligodeoxynucleotide to c-fos mRNA
    • Liu PK, Salminen A, He YY, Jiang MH, Xue JJ, Liu JS, Hsu CY (1994) Suppression of ischemia-induced fos expression and AP-1 activity by an antisense oligodeoxynucleotide to c-fos mRNA. Ann Neurol 36:566-576.
    • (1994) Ann Neurol , vol.36 , pp. 566-576
    • Liu, P.K.1    Salminen, A.2    He, Y.Y.3    Jiang, M.H.4    Xue, J.J.5    Liu, J.S.6    Hsu, C.Y.7
  • 38
    • 0032555716 scopus 로고    scopus 로고
    • Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
    • Luo X, Budihardjo I, Zou H, Slaughter C, Wang X (1998) Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481-490.
    • (1998) Cell , vol.94 , pp. 481-490
    • Luo, X.1    Budihardjo, I.2    Zou, H.3    Slaughter, C.4    Wang, X.5
  • 39
    • 0037085380 scopus 로고    scopus 로고
    • Rapid kinetics of tBid-induced cytochrome c and Smac/DIA-BLO release and mitochondrial depolarization
    • Madesh M, Antonsson B, Srinivasula SM, Alnemri ES, Hajnoczky G (2002) Rapid kinetics of tBid-induced cytochrome c and Smac/DIA-BLO release and mitochondrial depolarization. J Biol Chem 277:5651-5659.
    • (2002) J Biol Chem , vol.277 , pp. 5651-5659
    • Madesh, M.1    Antonsson, B.2    Srinivasula, S.M.3    Alnemri, E.S.4    Hajnoczky, G.5
  • 40
    • 0034839145 scopus 로고    scopus 로고
    • Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells
    • Martin D, Salinas M, Lopez-Valdaliso R, Serrano E, Recuero M, Cuadrado A (2001) Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells. J Neurochem 78:1000-1008.
    • (2001) J Neurochem , vol.78 , pp. 1000-1008
    • Martin, D.1    Salinas, M.2    Lopez-Valdaliso, R.3    Serrano, E.4    Recuero, M.5    Cuadrado, A.6
  • 41
    • 0022156464 scopus 로고
    • Neuronal origin of a cerebral amyloid: Neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels
    • Masters CL, Multhaup G, Simms G, Pottgiesser J, Martins RN, Beyreuther K (1985) Neuronal origin of a cerebral amyloid: Neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J 4:2757-2763.
    • (1985) EMBO J , vol.4 , pp. 2757-2763
    • Masters, C.L.1    Multhaup, G.2    Simms, G.3    Pottgiesser, J.4    Martins, R.N.5    Beyreuther, K.6
  • 42
    • 0034643895 scopus 로고    scopus 로고
    • Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells
    • Misonou H, Morishima-Kawashima M, Ihara Y (2000) Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. Biochemistry 39:6951-6959.
    • (2000) Biochemistry , vol.39 , pp. 6951-6959
    • Misonou, H.1    Morishima-Kawashima, M.2    Ihara, Y.3
  • 43
    • 0028491538 scopus 로고
    • Microvascular pathology and vascular basement membrane components in Alzheimer's disease
    • Perlmutter LS (1994) Microvascular pathology and vascular basement membrane components in Alzheimer's disease. Mol Neurobiol 9:33-40.
    • (1994) Mol Neurobiol , vol.9 , pp. 33-40
    • Perlmutter, L.S.1
  • 44
    • 0032512867 scopus 로고    scopus 로고
    • Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and beta-alanine
    • Preston JE, Hipkiss AR, Himsworth DT, Romero IA, Abbott JN (1998) Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and beta-alanine. Neurosci Lett 242:105-108.
    • (1998) Neurosci Lett , vol.242 , pp. 105-108
    • Preston, J.E.1    Hipkiss, A.R.2    Himsworth, D.T.3    Romero, I.A.4    Abbott, J.N.5
  • 45
    • 0030929498 scopus 로고    scopus 로고
    • beta-amyloid induces cerebrovascular endothelial dysfunction in the rat brain
    • Price JM, Sutton ET, Hellermann A, Thomas T (1997) beta-Amyloid induces cerebrovascular endothelial dysfunction in the rat brain. Neurol Res 19:534-538.
    • (1997) Neurol Res , vol.19 , pp. 534-538
    • Price, J.M.1    Sutton, E.T.2    Hellermann, A.3    Thomas, T.4
  • 46
    • 0033746534 scopus 로고    scopus 로고
    • Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells
    • Pritchard DE, Singh J, Carlisle DL, Patierno SR (2000) Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells. Carcinogenesis 21:2027-2033.
    • (2000) Carcinogenesis , vol.21 , pp. 2027-2033
    • Pritchard, D.E.1    Singh, J.2    Carlisle, D.L.3    Patierno, S.R.4
  • 48
    • 0030698127 scopus 로고    scopus 로고
    • The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
    • Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (1997) The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J 16:6914-6925.
    • (1997) EMBO J , vol.16 , pp. 6914-6925
    • Roy, N.1    Deveraux, Q.L.2    Takahashi, R.3    Salvesen, G.S.4    Reed, J.C.5
  • 49
    • 0033600274 scopus 로고    scopus 로고
    • Translating cell biology into therapeutic advances in Alzheimer's disease
    • Selkoe DJ (1999) Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399:A23-31.
    • (1999) Nature , vol.399
    • Selkoe, D.J.1
  • 51
    • 0030862707 scopus 로고    scopus 로고
    • Morpholino antisense oligomers: Design, preparation, and properties
    • Summerton J, Weller D (1997) Morpholino antisense oligomers: Design, preparation, and properties. Antisense Nucleic Acid Drug Dev 7:187-195.
    • (1997) Antisense Nucleic Acid Drug Dev , vol.7 , pp. 187-195
    • Summerton, J.1    Weller, D.2
  • 53
    • 0037192790 scopus 로고    scopus 로고
    • Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein
    • Sun XM, Bratton SB, Butterworth M, MacFarlane M, Cohen GM (2002) Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein. J Biol Chem 277:11345-11351.
    • (2002) J Biol Chem , vol.277 , pp. 11345-11351
    • Sun, X.M.1    Bratton, S.B.2    Butterworth, M.3    MacFarlane, M.4    Cohen, G.M.5
  • 54
    • 0030851944 scopus 로고    scopus 로고
    • Superoxide free radical and intracellular calcium mediate A beta(1-42) induced endothelial toxicity
    • Suo Z, Fang C, Crawford F, Mullan M (1997) Superoxide free radical and intracellular calcium mediate A beta(1-42) induced endothelial toxicity. Brain Res 762:144-152.
    • (1997) Brain Res , vol.762 , pp. 144-152
    • Suo, Z.1    Fang, C.2    Crawford, F.3    Mullan, M.4
  • 55
    • 0030015872 scopus 로고    scopus 로고
    • In vitro efficacy of morpholino-modified antisense oligomers directed against tumor necrosis factor-alpha mRNA
    • Taylor MF, Paulauskis JD, Weller DD, Kobzik L (1996) In vitro efficacy of morpholino-modified antisense oligomers directed against tumor necrosis factor-alpha mRNA. J Biol Chem 271:17445-17452.
    • (1996) J Biol Chem , vol.271 , pp. 17445-17452
    • Taylor, M.F.1    Paulauskis, J.D.2    Weller, D.D.3    Kobzik, L.4
  • 56
    • 0029670094 scopus 로고    scopus 로고
    • beta-amyloid-mediated vasoactivity and vascular endothelial damage
    • Thomas T, Thomas G, McLendon C, Sutton T, Mullan M (1996) beta-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380:168-171.
    • (1996) Nature , vol.380 , pp. 168-171
    • Thomas, T.1    Thomas, G.2    McLendon, C.3    Sutton, T.4    Mullan, M.5
  • 57
    • 0036204018 scopus 로고    scopus 로고
    • Cell death regulation by the mammalian IAP antagonist Diablo/Smac
    • Verhagen AM, Vaux DL (2002) Cell death regulation by the mammalian IAP antagonist Diablo/Smac. Apoptosis 7:163-166.
    • (2002) Apoptosis , vol.7 , pp. 163-166
    • Verhagen, A.M.1    Vaux, D.L.2
  • 59
    • 0034921727 scopus 로고    scopus 로고
    • Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs
    • Verhagen AM, Coulson EJ, Vaux DL (2001) Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. Genome Biol 2:3009.1-3009.10.
    • (2001) Genome Biol , vol.2 , pp. 30091-300910
    • Verhagen, A.M.1    Coulson, E.J.2    Vaux, D.L.3
  • 60
    • 0030779705 scopus 로고    scopus 로고
    • Animal models of cerebral beta-amyloid angiopathy
    • Walker LC (1997) Animal models of cerebral beta-amyloid angiopathy. Brain Res Brain Res Rev 25:70-84.
    • (1997) Brain Res Brain Res Rev , vol.25 , pp. 70-84
    • Walker, L.C.1
  • 61
    • 0035890085 scopus 로고    scopus 로고
    • The expanding role of mitochondria in apoptosis
    • Wang X (2001) The expanding role of mitochondria in apoptosis. Genes Dev 15:2922-2933.
    • (2001) Genes Dev , vol.15 , pp. 2922-2933
    • Wang, X.1
  • 62
    • 0035049449 scopus 로고    scopus 로고
    • Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release
    • Whitfield J, Neame SJ, Paquet L, Bernard O, Ham J (2001) Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 29:629-643.
    • (2001) Neuron , vol.29 , pp. 629-643
    • Whitfield, J.1    Neame, S.J.2    Paquet, L.3    Bernard, O.4    Ham, J.5
  • 65
    • 0026742181 scopus 로고
    • Receptor-linked hydrolysis of phosphoinositides and production of prostacyclin in cerebral endothelial cells
    • Xu J, Qu ZX, Moore SA, Hsu CY, Hogan EL (1992) Receptor-linked hydrolysis of phosphoinositides and production of prostacyclin in cerebral endothelial cells. J Neurochem 58:1930-1935.
    • (1992) J Neurochem , vol.58 , pp. 1930-1935
    • Xu, J.1    Qu, Z.X.2    Moore, S.A.3    Hsu, C.Y.4    Hogan, E.L.5
  • 66
    • 0032568836 scopus 로고    scopus 로고
    • Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death
    • Xu J, Yeh CH, Chen S, He L, Sensi SL, Canzoniero LM, Choi DW, Hsu CY (1998) Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death. J Biol Chem 273:16521-16526.
    • (1998) J Biol Chem , vol.273 , pp. 16521-16526
    • Xu, J.1    Yeh, C.H.2    Chen, S.3    He, L.4    Sensi, S.L.5    Canzoniero, L.M.6    Choi, D.W.7    Hsu, C.Y.8
  • 67
    • 0033945093 scopus 로고    scopus 로고
    • Oxygen-glucose deprivation induces inducible nitric oxide synthase and nitrotyrosine expression in cerebral endothelial cells
    • Xu J, He L, Ahmed SH, Chen SW, Goldberg MP, Beckman JS, Hsu CY (2000) Oxygen-glucose deprivation induces inducible nitric oxide synthase and nitrotyrosine expression in cerebral endothelial cells. Stroke 31:1744-1751.
    • (2000) Stroke , vol.31 , pp. 1744-1751
    • Xu, J.1    He, L.2    Ahmed, S.H.3    Chen, S.W.4    Goldberg, M.P.5    Beckman, J.S.6    Hsu, C.Y.7
  • 68
    • 0034981701 scopus 로고    scopus 로고
    • Amyloid beta peptide-induced cerebral endothelial cell death involves mitochondrial dysfunction and caspase activation
    • Xu J, Chen S, Ku G, Ahmed SH, Chen H, Hsu CY (2001a) Amyloid beta peptide-induced cerebral endothelial cell death involves mitochondrial dysfunction and caspase activation. J Cereb Blood Flow Metab 21:702-710.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 702-710
    • Xu, J.1    Chen, S.2    Ku, G.3    Ahmed, S.H.4    Chen, H.5    Hsu, C.Y.6
  • 70
    • 0035144802 scopus 로고    scopus 로고
    • Glucocorticoid receptor-mediated suppression of activator protein-1 activation and matrix metalloproteinase expression after spinal cord injury
    • Xu J, Kim GM, Ahmed SH, Yan P, Xu XM, Hsu CY (2001c) Glucocorticoid receptor-mediated suppression of activator protein-1 activation and matrix metalloproteinase expression after spinal cord injury. J Neurosci 21:92-97.
    • (2001) J Neurosci , vol.21 , pp. 92-97
    • Xu, J.1    Kim, G.M.2    Ahmed, S.H.3    Yan, P.4    Xu, X.M.5    Hsu, C.Y.6
  • 71
    • 0029896354 scopus 로고    scopus 로고
    • Mechanisms of neuronal degeneration in Alzheimer's disease
    • Yankner BA (1996) Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16:921-932.
    • (1996) Neuron , vol.16 , pp. 921-932
    • Yankner, B.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.