DNA damage and activated caspase-3 expression in neurons and astrocytes: Evidence for apoptosis in frontotemporal dementia

Experimental Neurology

Volumn 163, Issue 1, 2000, Pages 9-19

  Su, Joseph H ^a   Nichol, Kathryn E ^a   Sitch, Tom ^a   Sheu, Philip ^a   Chubb, Charlie ^a   Miller, Bruce L ^b   Tomaselli, Kevin J ^c   Kim, Ronald C ^a   Cotman, Carl W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PFIZER INC   (United States)

Author keywords

Activated caspase 3; Apoptosis; Astrocyte; Degeneration; DNA fragmentation; Frontotemporal dementia; Neuron; Neuropathology

Indexed keywords

CASPASE 3; DNA FRAGMENT;

ADULT; AGED; APOPTOSIS; ARTICLE; ASTROCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DEMENTIA; DNA DAMAGE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE DIAGNOSIS;

EID: 0034073966     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7340     Document Type: Article

References (52)

1. Alnemri E. S., Livingston D. J., Nicholson D. W., Salvesen G., Thornberry N. A., Wong W. W., Yuan J. Human Ice/Ced-3 protease nomenclature. Cell. 87:1996.
2. Anderson A. J., Su J. H., Cotman C. W. DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J. Neurosci. 16:1996;1710-1719.
3. Biernat J., Mandelkow E.-M., Schroter C., Lichtenberg-Kraag B., Steiner B., Berling B., Meyer H., Merchen M., Vandermeeren A., Goedert M., Mandelkow E. The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motif upstream of the microtubule binding region. EMBO J. 11:1992;1593-1597.
4. 396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron. 10:1993;1089-1099.
5. Brun A. Frontal lobe degeneration of non-Alzheimer type. I. Neuropathology. Arch. Gerontol. Geriat. 6:1987;193-208.
6. Brun A. Frontal lobe degeneration of non-Alzheimer type revisited. Dementia. 4:1993;126-131.
7. Cajal S. R. Y. Contribución al conocimiento de la neuroglia del cerebro humano. Trab. Lab. Inv. Biol. Univ. Madrid. 11:1913;255-315.
8. Chinnaiyan A. M., O'Rourke K., Lane B. R., Dixit V. M. Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death. Science. 275:1997;1122-1126.
9. Clinton J., A. D. M., Roberts G. W. Frontal lobe dementia is not a variant of prion disease. Neurosci. Lett. 164:1993;1-4.
10. Darmon A. J., Ley T. J., Nicholson D. W., Bleackley R. C. Cleavage of cpp32 by granzyme b represents a critical role for granzyme B in the induction of target cell DNA fragmentation. J. Biol. Chem. 271:1996;21709-21712.
11. Datta R., Kojima H., Banach D., Bump N. J., Talanian R. V., Alnemri E. S., Weichselbaum R. R., Wong W. W., Kufe D. W. Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. J. Biol. Chem. 272:1997;1965-1969.
12. Enari M., Talanian R. V., Wong W. W., Nagata S. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature. 380:1996;723-726.
13. Fernandes-Alnemri T., Takahashi A., Armstrong R., Krebs J., Fritz L., Tomaselli K. J., Wang L., Yu Z., Croce C. M., Salveson G., Earnshaw W. C., Litwack G., Alnemri E. S. Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res. 55:1995;6045-6052.
14. Gavrieli Y., Sherman Y., Ben-Saason S. A. Identification of programmed cell death In situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:1992;493-501.
15. Gervais F. G., Xu D., Robertson G. S., Vaillancourt J. P. Involvement of Caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Aβ peptide formation. Cell. 97:1999;395-406.
16. Gold R., Schmied M., Rothe G., Zischier H., Breitschope H., Wekerle H., Lassmann H. Detection of DNA fragmentation in apoptosis: Application of in situ nick translation to cell culture systems and tissue sections. J. Histochem. Cytochem. 41:1993;1023-1030.
17. Gustafson L. Frontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosis. Arch. Gerontol. Geriat. 6:1987;209-223.
18. Hauw J. J., Duyckaerts C., Seilhean D., Camilleri S., Sazdovitch V., Rancurel G. The neuropathologic diagnostic criteria of frontal lobe dementia revisited - A study of ten consecutive cases. J. Neural Trans. 47:1996;47-59.
19. Irmler M., Hofmann K., Vaux D., Tschopp J. Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4. FEBS Lett. 406:1997;189-190.
20. Jacobson M. D., Weil M., Raff M. C. Role of Ced3/Ice-family proteases in staurosporine-induced programmed cell death. J. Cell Biol. 133:1996;1041-1051.
21. Kluck R. M., BossyWetzel E., Green D. R., Newmeyer D. D. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science. 275:1997;1132-1136.
22. Kouroku Y., Urase K., Fujita E., Isahara K., Ohsawa Y., Uchiyama Y., Momoi M. Y., Momoi T. Detection of activated Caspase-3 by a cleavage site-directed antiserum during naturally occurring DRG neurons apoptosis. Biochem. Biophys. Res. Commun. 247:1998;780-784.
23. Krajewska M., Wang H. G., Krajewski S., Zapata J. M., Shabaik A., Gascoyne R., Reed J. Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease. Cancer Res. 57:1997;1605-1613.
24. Kumar S., Lavin M. F. The Ice family of cysteine proteases as effectors of cell death. Cell Death Differ. 3:1996;255-267.
25. Lassmann H., Bancher C., Breitschopf H., Wegiel J., Bobinski M., Jellinger K., Wisniewski H. M. Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol. 89:1995;35-41.
26. Liu X. S., Kim C. N., Yang J., Jemmerson R., Others J HS. Induction of apoptotic program in cell-free extracts - Requirement for dATP and cytochrome C. Cell. 86:1996;147-157.
27. Liu X. S., Zou H., Slaughter C., Wang X. D. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell. 89:1997;175-184.
28. Lucassen P. J., Chung W. C. J., Vermeulen J. P., Campagne M. V. L., Dierendonck J. H. V., Swaab D. F. Microwave-enhanced in situ end-labeling of fragmented DNA: Parametric studies in relation to postmortem delay and fixation of rat and human brain. J. Histochem. Cytochem. 43:1995;1163-1171.
29. Mann D. M. A., South P. W., Snowden J. S., Neary D. Dementia of frontal lobe type - Neuropathology and immunohistochemistry. J. Neurol. Neurosurg. Psychiat. 56:1993;605-614.
30. Miller B. L., Cummings J. L., Villanueva-Meyer J., Boone K., Mehringer C. M., Lesser I. M., Mena I. Frontal lobe degeneration: Clinical, neuropsychological, and SPECT characteristics. Neurology. 41:1991;1374-1382.
31. Nagata S. Apoptosis by death factor. Cell. 88:1997;355-365.
32. Namura S., Zhu J., Fink K., Endres M., Srinivasan A., Tomaselli K. J., Yuan J., Moskowitz M. A. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J. Neurosci. 18:1998;3659-3668.
33. Neary D., Snowden J. S., Northen B., Goulding P. Dementia of frontal lobe type. J. Neurol. Neurosurg. Psychiat. 51:1988;353-361.
34. Nicholson D. W., Ali A., Thornberry N. A., Vaillancourt J. P., Ding C. K., Gallan M., Gareau Y., Griffin P. R., Labelle M., Lazebnik Y. A., Munday N. A., Raja S. M., Smulson M. E., Yamin T.-T., Yu V. L., Miller D. K. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 376:1995;37-43.
35. McCall M. A., Gregg R. G., Behringer R. R., Brenner M., Delaney C. L., Galbreath E. J., Zhang C. L., Pearce R. A., Chiu S. Y., Messing A. Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology. Proc. Nat. Acad. Sci. USA. 93:1996;6361-6366.
36. Nieto-Sampedro M., Mora F. Active microglia, sick astroglia and Alzheimer type dementias. NeuroRep. 5:1994;375-380.
37. Norton W. T., Aquino D. A., Hozumi I., Chiu F. C., Brosnan C. F. Quantitative aspects of reactive gliosis - A review. Neurochem. Res. 17:1992;877-885.
38. Patel T., Gores G. J., Kaufmann S. H. The role of proteases during apoptosis. FASEB J. 10:1996;587-597.
39. Sakahira H., Enari M., Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature. 391:1998;96-99.
40. Satoh M. S., Lindahl T. Enzymatic repair of oxidative DNA damage. Cancer Res. 54:1994;1899s-1901s.
41. Srinivasan A., Roth K. A., Sayers R. O., Shindler K. S., Wong A. M., Fritez L. C., Tomaselli K. J. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system. Cell Death Differ. 5:1998;1004-1016.
42. Stadelmann C., Deckwerth T. L., Srinivasan A., Bancher C., Wolfgang B., Jellinger K., Lassmann H. Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease: Evidence for apoptotic cell death. AJP. 155:1999;1459-1466.
43. Steward O., Torre E. R., Phillips L. L., Trimmer P. A. The process of reinnervation in the dentate gyrus of adult rats: time course of increases in mRNA for glial fibrillary acidic protein. J. Neurosci. 10:1990;2373-2384.
44. Su J. H., Anderson A. J., Cummings B. J., Cotman C. W. Immunohistochemical evidence for apoptosis in Alzheimer's disease. NeuroRep. 5:1994;2529-2533.
45. Su J. H., Cummings B. J., Cotman C. W. Identification and distribution of axonal dystrophic neurites in Alzheimer's disease. Brain Res. 625:1993;228-237.
46. Su J. H., Cummings B. J., Cotman C. W. Subpopulations of dystrophic neurites in Alzheimer's brain with distinct immunocytochemical and argentophilic characteristics. Brain Res. 637:1994;37-44.
47. Su J. H., Deng G., Cotman C. W. Bax protein expression is increased in Alzheimer's brain: Correlation with DNA damage, Bcl-2 expression, and brain pathology. J. Neuropathol. Exp. Neurol. 56:1997;86-93.
48. Su J. H., Satou T., Anderson A. J., Cotman C. W. Upregulation of Bcl-2 is associated with neuronal DNA damage in Alzheimer's disease. NeuroRep. 7:1996;437-440.
49. Tomimoto H., Akiguchi I., Wakita H., Suenaga T., Nakamura S., Kimura J. Regressive changes of astroglia in white matter lesions in cerebrovascular disease and Alzheimer's disease patients. Acta Neuropathol. 94:1997;146-152.
50. Wang L., Miura M., Bergerson L., Zhu H., Yuan J. Ich-1, an ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell. 78:1994;739-750.
51. Yang J., Liu X. S., Bhalla K., Kim C. N., Others J HS. Prevention of apoptosis by Bcl-2: Release of cytochrome C from mitochondria blocked. Science. 275:1997;1129-1132.
52. Yuan J. Y., Shaham S., Ledoux S., Ellis M. H., Horvitz R. H. The c-elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1-beta-converting enzyme. Cell. 75:1993;641-652.