Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death

Journal of Molecular Neuroscience

Volumn 18, Issue 3, 2002, Pages 189-201

  Leutz, Steffen ^a   Steiner, Barbara ^a   Marques, Celio A ^a   Haass, Christian ^b   Müller, Walter E ^a   Eckert, Anne ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Apoptosis; Cell death; PC12 cells; Staurosporine; Swedish mutation

Indexed keywords

AMYLOID PRECURSOR PROTEIN; MUTANT PROTEIN; NERVE GROWTH FACTOR; STAUROSPORINE; DNA FRAGMENT; ENZYME INHIBITOR; LACTATE DEHYDROGENASE; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL METABOLISM; CELL STRAIN; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSFECTION; IN VITRO STUDY; MEMBRANE DAMAGE; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SENSITIZATION; SERUM; WILD TYPE; ANIMAL; CHEMISTRY; CULTURE MEDIUM; FLOW CYTOMETRY; GENETICS; HUMAN; METABOLISM; MUTATION; NERVE CELL; NICK END LABELING; PHYSIOLOGY; SECRETION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMAL; APOPTOSIS; CULTURE MEDIA; DNA FRAGMENTATION; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMAN; IN SITU NICK-END LABELING; LACTATE DEHYDROGENASE; MUTATION; NEURONS; OXIDATIVE STRESS; PC12 CELLS; RATS; STAUROSPORINE; SUPPORT, NON-U.S. GOV'T; TETRAZOLIUM SALTS; THIAZOLES; ANIMALS; HUMANS; L-LACTATE DEHYDROGENASE;

ANIMALIA;

EID: 0036014113     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:18:3:189     Document Type: Article

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