Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity

Journal of Neuroscience Research

Volumn 74, Issue 2, 2003, Pages 296-308

  Tsaknaridis, Laura ^a   Spencer, Leslie ^a   Culbertson, Nicole ^a   Hicks, Kevin ^a   LaTocha, Dorian ^a   Chou, Yuan K ^a,b   Whitham, Ruth H ^a,b   Bakke, Antony ^b   Jones, Richard E ^a,b   Offner, Halina ^a,b   Bourdette, Dennis N ^a,b   Vandenbark, Arthur A ^a,b,c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Age dependence; Human CD4+CD25+ T cells; Regulatory T cells

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 17; INTERLEUKIN 2;

ADULT; AGE DISTRIBUTION; ARTICLE; AUTOIMMUNE DISEASE; BLOOD SAMPLING; CELL ASSAY; CELL CONTACT; CONTROLLED STUDY; DONOR; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN EXPERIMENT; INHIBITION KINETICS; LYMPHOCYTE SUBPOPULATION; MALE; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0141481855     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10766     Document Type: Article

References (52)

1. + T cell numbers. J Immunol 169:4850-4860.
2. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol 166:3008-3018.
3. Asano M, Toda M, Sakaguchi N, Sakaguchi S. 1996. Autoimmune disease as a consequence of develomental abnormality of a T cell subpopulation. J Exp Med 184:387-396.
4. high regulatory cells in human peripheral blood. J Immunol 167:1245-1253.
5. +high regulatory T cell function. J Immunol 169:6210-6217.
6. + regulatory T cells control Leishmania major persistence and immunity. Nature 420:502-507.
7. + T cells for self TCR determinants. J Clin Invest (Submitted).
8. Chambers CA, Kuhns MS, Egen JG, Allison JP. 2001. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol 19:565-594.
9. + T cells with regulatory properties from human blood. J Exp Med 193:1303-1310.
10. Ermann J, Szanya V, Ford GS, Paragas V, Fathman CG, Lejon K. 2001. CD4(+)CD25(+) T cells facilitate the induction of T cell anergy. J Immunol 167:4271-4275.
11. Gavin MA, Clarke SR, Negrou E, Gallegos A, Rudensky A. 2002. Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol 3:33-41.
12. George AJT, Ritter MA. 1996. Thymic involution with ageing: obsolescence or good housekeeping? Immunol Today 17:267-272.
13. Green EA, Choi Y, Flavell RA. 2002. Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 16:183-191.
14. Hirokawa K, Utsuyama M, Kasai M, Kurashima C, Ishijima S, Zheng Y-X. 1994. Understanding the mechanism of the age-change of thymic function to promote T cell differentiation. Immunol Lett 40:269-277.
15. Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J, Enk AH. 2002. Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med 196:255-260.
16. + regulatory T cells induced by an agonist self-peptide. Nat Immunol 2:301-306.
17. Kawahata K, Misaki Y, Yamauchi M, Tsunekawa S, Setoguchi K, Miyazaki J, Yamamoto K. 2002. Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J Immunol 168:4399-4405.
18. + regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunogregulation of alloresponses. J Immunol 168:1080-1086.
19. + regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol 169:4712-4716.
20. + T cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 193:1295-1302.
21. Malek TR, Yu A, Vincek V, Scibelli P, Kong L. 2002. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the non-redundant function of IL-2. Immunity 17:167-178.
22. Maloy KJ, Powrie F. 2001. Regulatory T cells in the control of immune pathology. Nat Immunol 2:816-822.
23. Mason D, Powrie F. 1998. Control of immune pathology by regulatory T cells. Curr Opin Immunol 10:649-655.
24. + immunoregulatory T cells: gene expression analysis reveals a functional role for glucocorticoid-induced TNF receptor. Immunity 16:311-323.
25. Miller RA. 1984. Age-associated decline in precursor frequency for different T cell mediated reactions with preservation of helper or cytotoxic effect per precursor cell. J Immunol 132:63-68.
26. + T cells. Proc Natl Acad Sci USA 99:8832-8837.
27. Nakamura K, Kitani A, Strober W. 2001. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 194:629-644.
28. Ng WF, Duggan PJ, Ponchel F, Matarese G, Lombardi G, Edwards AD, Isaacs JD, Lechler RI. 2001. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood 98:2736-2744.
29. Papiernik M, deMoraes ML, Pontoux C, Vasseur F, Penit C. 1998. Regulatory CD4 T cells: expression of IL-2R a chain, resistance to clonal deletion and IL-2 dependency. Int Immunol 10:371-378.
30. Pontoux C, Banz A, Papiernik M. 2002. Natural CD4 CD25(+) regulatory T cells control the burst of superantigen-induced cytokine production: the role of IL-10. Int Immunol 14:233-239.
31. + regulatory cells that control intestinal inflammation. J Exp Med 192:295-302.
32. Romagnoli P, Hudrisier D, vanMeerwijk JP. 2002. Preferential recognition of self antigens despite normal thymic deletion of CD4(+)CD25(+) regulatory T cells. J Immunol 168:1644-1648.
33. Roncarolo MG, Levings MK. 2000. The role of different subsets of T regulatory cells in controlling autoimmunity. Curr Opin Immunol 12:676-683.
34. Rose NR. 1994. Thymus function, ageing and autoimmunity. Immunol Lett 40:225-230.
35. Sakaguchi S. 2000. Animal models of autoimmunity and their relevance to human diseases. Curr Opin Immunol 12:684-690.
36. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. 1995. Immunologic self-tolerance maintained by activtaed T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155:1151-1164.
37. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431-440.
38. Shevach EM. 2000. Regulatory T cells in autoimmunity. Annu Rev Immunol 18:423-449.
39. - T cells in aged mice are hyporesponsive and exhibit suppressive activity. J Immunol 170:1675-1682.
40. + regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 3:135-142.
41. - subpopulations. J Immunol 165:3105-3110.
42. + thymocytes and peripheral T cells have immune suppressive activity. Eur J Immunol 31:1247-1254.
43. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol 160:1212-1218.
44. Suto A, Nakajima H, Ikeda K, Kubo S, Nakayama T, Taniguchi M, Saito Y, Iwamoto I. 2002. CD4(+)CD25(+) T-cell development is regulated by at least 2 distinct mechanisms. Blood 99:555-560.
45. + T cells: a highly differentiated and apoptosis-prone population. Eur J Immunol 31:1122-1131.
46. + regulatory T cells. Eur J Immunol 32:1621-1630.
47. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 10:1969-1980.
48. + regulatory T cells constitutively expressing cytotoxic lymphocyte-associated antigen 4. J Exp Med 192:303-309.
49. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188:287-296.
50. + T cells in thumus, cord and adult blood. Immunology 106:190-199.
51. Zhang X, Izikson L, Liu L, Weiner HL. 2001. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol 167:4245-4253.
52. - precursors. J Immunol 169:4183-4189.