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5
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0030704726
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+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
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of outstanding interest. This paper shows that IL-10 is a growth factor for T reg cells in vitro that can mediate bystander suppression in vivo.
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Groux, H.1
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De Vries, J.E.6
Roncarolo, M.G.7
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6
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0031569530
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CD4+ T cell down-regulation in human intestinal mucosa: Evidence for intestinal tolerance to luminal bacterial antigens
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of special interest. This reports that humans have T reg cells in the intestine.
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Khoo UY, Proctor IE, Macpherson AJ. CD4+ T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens. of special interest J Immunol. 158:1997;3626-3634 This reports that humans have T reg cells in the intestine.
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Khoo, U.Y.1
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0029586031
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Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)
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Duchmann, R.1
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0030847054
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of special interest. This provides an up-to-date review.
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Weiner HL. Oral tolerance: immune mechanisms and treatment of autoimmune diseases. of special interest Immunol Today. 18:1997;335-343 This provides an up-to-date review.
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Weiner, H.L.1
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9
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Chen Y, Kuchroo VK, Inobe J-I, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 265:1994;1237-1240.
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Chen, Y.1
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10
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0029995799
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Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance
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Neurath MF, Fuss I, Kelsall BL, Presky DH, Waegell W, Strober W. Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance. J Exp Med. 183:1996;2605-2616.
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Neurath, M.F.1
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11
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TGF-beta induced by oral tolerance ameliorates experimental tracheal eosinophilia
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Haneda K, Sano K, Tamura G, Sato T, Habu S, Shirato K. TGF-beta induced by oral tolerance ameliorates experimental tracheal eosinophilia. J Immunol. 159:1997;4484-4490.
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Haneda, K.1
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12
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0028202792
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Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens
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Weiner HL, Friedman A, Miller A, Khoury SJ, al-Sabbagh A, Santos L, Sayegh M, Nussenblatt RB, Trentham DE, Hafler DA. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol. 12:1994;809-837.
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Weiner, H.L.1
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Santos, L.6
Sayegh, M.7
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13
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0030060229
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Oral antigen inhibits priming of CD8+ CTL, CD4+ T cells, and antibody responses while activating CD8+ suppressor T cells
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Ke Y, Kapp JA. Oral antigen inhibits priming of CD8+ CTL, CD4+ T cells, and antibody responses while activating CD8+ suppressor T cells. J Immunol. 156:1996;916-921.
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Ke, Y.1
Kapp, J.A.2
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0027993367
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Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells
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McMenamin C, Pimm C, McKersey M, Holt PG. Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells. Science. 265:1994;1869-1871.
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McMenamin, C.1
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McKersey, M.3
Holt, P.G.4
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16
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0029063115
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Gamma delta T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens
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McMenamin C, McKersey M, Kuhnlein P, Hunig T, Holt PG. Gamma delta T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens. J Immunol. 154:1995;4390-4394.
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McMenamin, C.1
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Hunig, T.4
Holt, P.G.5
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17
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0030456670
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Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes
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Harrison LC, Dempsey-Collier M, Kramer DR, Takahashi K. Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes. J Exp Med. 184:1996;2167-2174.
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Harrison, L.C.1
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Kramer, D.R.3
Takahashi, K.4
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18
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0032473551
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Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8+ or T cell receptor (TCR)-gamma/delta+ T cells or interferon (IFN)-gamma in a murine model of allergen sensitization
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of outstanding interest. This paper provides evidence for redundancy in mechanisms controlling IgE synthesis.
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Seymour BW, Gershwin LJ, Coffman RL. Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8+ or T cell receptor (TCR)-gamma/delta+ T cells or interferon (IFN)-gamma in a murine model of allergen sensitization. of outstanding interest J Exp Med. 187:1998;721-731 This paper provides evidence for redundancy in mechanisms controlling IgE synthesis.
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J Exp Med
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, pp. 721-731
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Seymour, B.W.1
Gershwin, L.J.2
Coffman, R.L.3
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19
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0029659056
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The physiological role of regulatory T cells in the prevention of autoimmunity: The function of the thymus in the generation of the regulatory T cell subset
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Saoudi A, Seddon B, Heath V, Fowell D, Mason D. The physiological role of regulatory T cells in the prevention of autoimmunity: the function of the thymus in the generation of the regulatory T cell subset. Immunol Rev. 149:1996;195-216.
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Saoudi, A.1
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Heath, V.3
Fowell, D.4
Mason, D.5
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20
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0029788211
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Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
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Asano M, Toda M, Sakaguchi N, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med. 184:1996;387-396.
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Asano, M.1
Toda, M.2
Sakaguchi, N.3
Sakaguchi, S.4
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21
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0031939403
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CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
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Suri-Payer E, Amar AZ, Thornton AM, Shevach EM. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol. 160:1998;1212-1218.
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Suri-Payer, E.1
Amar, A.Z.2
Thornton, A.M.3
Shevach, E.M.4
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22
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0029946516
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Administration of anti-interleukin-2 receptor alpha antibody in vivo induces localized autoimmune disease
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Taguchi O, Takahashi T. Administration of anti-interleukin-2 receptor alpha antibody in vivo induces localized autoimmune disease. Eur J Immunol. 26:1996;1608-1612.
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Eur J Immunol
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Taguchi, O.1
Takahashi, T.2
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23
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7144259082
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Regulatory CD4 T cells: Expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
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of special interest. The authors present evidence that regulatory T cells are not susceptible to antigen-induced intrathymic clonal deletion.
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Papiernik M, de Moraes ML, Pontoux C, Vasseur F, Penit C. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. of special interest Int Immunol. 10:1998;371-378 The authors present evidence that regulatory T cells are not susceptible to antigen-induced intrathymic clonal deletion.
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(1998)
Int Immunol
, vol.10
, pp. 371-378
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Papiernik, M.1
De Moraes, M.L.2
Pontoux, C.3
Vasseur, F.4
Penit, C.5
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24
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0344404151
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Systemic autoimmune disease as a consequence of defective lymphocyte death
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of special interest. This provides a comprehensive review of the role of IL-2 in immune regulation.
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Hunig T, Schimpl A. Systemic autoimmune disease as a consequence of defective lymphocyte death. of special interest Curr Opin Immunol. 9:1997;826-830 This provides a comprehensive review of the role of IL-2 in immune regulation.
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(1997)
Curr Opin Immunol
, vol.9
, pp. 826-830
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Hunig, T.1
Schimpl, A.2
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25
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0027509812
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Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential
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Fowell D, Mason D. Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential. J Exp Med. 177:1993;627-636.
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, pp. 627-636
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Fowell, D.1
Mason, D.2
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26
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2642624436
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CD4+CD8-thymocytes that express L-selectin protect rats from diabetes upon adoptive transfer
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Seddon B, Saoudi A, Nicholson M, Mason D. CD4+CD8-thymocytes that express L-selectin protect rats from diabetes upon adoptive transfer. Eur J Immunol. 26:1996;2702-2708.
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Eur J Immunol
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Seddon, B.1
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Nicholson, M.3
Mason, D.4
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27
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0032489860
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Alpha/beta-T cell receptor (TCR)+CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10
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of special interest. This paper demonstrates that the NOD mouse develops IDDM because of a lack of IL-4 and that this deficiency can be made good by NKT thymocytes which do not express L-selectin and which are deficient in these animals.
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Hammond KJL, Poulton LD, Palmisano LJ, Silveira PA, Godfrey DI, Baxter AG. alpha/beta-T cell receptor (TCR)+CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10. of special interest J Exp Med. 187:1998;1047-1056 This paper demonstrates that the NOD mouse develops IDDM because of a lack of IL-4 and that this deficiency can be made good by NKT thymocytes which do not express L-selectin and which are deficient in these animals.
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(1998)
J Exp Med
, vol.187
, pp. 1047-1056
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Hammond, K.J.L.1
Poulton, L.D.2
Palmisano, L.J.3
Silveira, P.A.4
Godfrey, D.I.5
Baxter, A.G.6
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29
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0026708993
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Cytokine production by mature and immature CD4-CD8- T cells. Alpha beta-T cell receptor+ CD4-CD8- T cells produce IL-4
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Zlotnik A, Godfrey DI, Fischer M, Suda T. Cytokine production by mature and immature CD4-CD8- T cells. Alpha beta-T cell receptor+ CD4-CD8- T cells produce IL-4. J Immunol. 149:1992;1211-1215.
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J Immunol
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Zlotnik, A.1
Godfrey, D.I.2
Fischer, M.3
Suda, T.4
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30
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0031573072
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IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function
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of special interest. This paper confirms the finding in reference [31], that NOD mice are protected from IDDM if provided with an exogenous source of IL-4.
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Cameron MJ, Arreaza GA, Zucker P, Chensue SW, Strieter RM, Chakrabarti S, Delovitch TL. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function. of special interest J Immunol. 159:1997;4686-4692 This paper confirms the finding in reference [31], that NOD mice are protected from IDDM if provided with an exogenous source of IL-4.
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J Immunol
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Cameron, M.J.1
Arreaza, G.A.2
Zucker, P.3
Chensue, S.W.4
Strieter, R.M.5
Chakrabarti, S.6
Delovitch, T.L.7
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31
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0029838995
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Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice
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Mueller R, Krahl T, Sarvetnick N. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J Exp Med. 184:1996;1093-1099.
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J Exp Med
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Mueller, R.1
Krahl, T.2
Sarvetnick, N.3
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32
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0032495536
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Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes
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of special interest. This gives an indication both that many individuals who develop IDDM have abnormal CD1-restricted T cells that are deficient in IL-4 production and that the pathogenesis of diabetes in these patients is similar to that in NOD mice.
-
Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M, Porcelli S, Schatz DA, Atkinson MA, Balk SP, et al. Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. of special interest Nature. 391:1998;177-181 This gives an indication both that many individuals who develop IDDM have abnormal CD1-restricted T cells that are deficient in IL-4 production and that the pathogenesis of diabetes in these patients is similar to that in NOD mice.
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(1998)
Nature
, vol.391
, pp. 177-181
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Wilson, S.B.1
Kent, S.C.2
Patton, K.T.3
Orban, T.4
Jackson, R.A.5
Exley, M.6
Porcelli, S.7
Schatz, D.A.8
Atkinson, M.A.9
Balk, S.P.10
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33
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0029835613
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Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium
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Modigliani Y, Coutinho A, Pereira P, Le Douarin N, Thomas-Vaslin V, Burlen-Defranoux O, Salaun J, Bandeira A. Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium. Eur J Immunol. 26:1996;1807-1815.
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Eur J Immunol
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Modigliani, Y.1
Coutinho, A.2
Pereira, P.3
Le Douarin, N.4
Thomas-Vaslin, V.5
Burlen-Defranoux, O.6
Salaun, J.7
Bandeira, A.8
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34
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0029659054
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The significance of immune suppression in normal self tolerance
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McCullagh P. The significance of immune suppression in normal self tolerance. Immunol Rev. 149:1996;127-153.
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Immunol Rev
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McCullagh, P.1
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35
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0032526605
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Thymus requirement and antigen dependency in the 'infectious' tolerance pathway in transplant recipients
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Onodera K, Volk HD, Ritter T, Kupiec-Weglinski JW. Thymus requirement and antigen dependency in the 'infectious' tolerance pathway in transplant recipients. J Immunol. 160:1998;5765-5772.
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Onodera, K.1
Volk, H.D.2
Ritter, T.3
Kupiec-Weglinski, J.W.4
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36
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0031945499
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How do monoclonal antibodies induce tolerance? A role for infectious tolerance?
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of special interest. This is a thorough review on antibody-induced tolerance.
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Waldmann H, Cobbold S. How do monoclonal antibodies induce tolerance? A role for infectious tolerance? of special interest Annu Rev Immunol. 16:1998;619-644 This is a thorough review on antibody-induced tolerance.
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Annu Rev Immunol
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Waldmann, H.1
Cobbold, S.2
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37
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0023155686
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Self tolerance and localized autoimmunity. Mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance
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Taguchi O, Nishizuka Y. Self tolerance and localized autoimmunity. Mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance. J Exp Med. 165:1987;146-156.
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Taguchi, O.1
Nishizuka, Y.2
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38
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0032521267
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Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose
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of special interest. This paper illustrates the transition from tolerance depending on clonal deletion - at high levels of bone marrow chimerism - to one depending on T reg cells at low levels of chimerism.
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Bemelman F, Honey K, Adams E, Cobbold S, Waldmann H. Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose. of special interest J Immunol. 160:1998;2645-2648 This paper illustrates the transition from tolerance depending on clonal deletion - at high levels of bone marrow chimerism - to one depending on T reg cells at low levels of chimerism.
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(1998)
J Immunol
, vol.160
, pp. 2645-2648
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Bemelman, F.1
Honey, K.2
Adams, E.3
Cobbold, S.4
Waldmann, H.5
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39
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0029806588
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Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE)
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Kumar V, Stellrecht K, Sercarz E. Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE). J Exp Med. 184:1996;1609-1617.
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J Exp Med
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Kumar, V.1
Stellrecht, K.2
Sercarz, E.3
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40
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0031913650
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Islet T cells secreting IFN-gamma in NOD mouse diabetes: Arrest by p277 peptide treatment
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Ablamunits V, Elias D, Reshef T, Cohen IR. Islet T cells secreting IFN-gamma in NOD mouse diabetes: arrest by p277 peptide treatment. J Autoimmun. 11:1998;73-81.
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J Autoimmun
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Ablamunits, V.1
Elias, D.2
Reshef, T.3
Cohen, I.R.4
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41
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0032126377
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Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases?
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of special interest. This proposes a provocative hypothesis that might explain how bacterial flora modify susceptibility to autoimmunity.
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van Eden W, van der Zee R, Paul AG, Prakken BJ, Wendling U, Anderton SM, Wauben MH. Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases? of special interest Immunol Today. 19:1998;303-307 This proposes a provocative hypothesis that might explain how bacterial flora modify susceptibility to autoimmunity.
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(1998)
Immunol Today
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, pp. 303-307
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Van Eden, W.1
Van Der Zee, R.2
Paul, A.G.3
Prakken, B.J.4
Wendling, U.5
Anderton, S.M.6
Wauben, M.H.7
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42
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0031446317
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CD4+ T-cell subsets in autoimmunity
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of special interest. This is a useful review that makes the point that the Th1/Th2 dichotomy is not a satisfactory explanation for self tolerance that is mediated by T reg cells.
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O'Garra A, Steinman L, Gijbels K. CD4+ T-cell subsets in autoimmunity. of special interest Curr Opin Immunol. 9:1997;872-883 This is a useful review that makes the point that the Th1/Th2 dichotomy is not a satisfactory explanation for self tolerance that is mediated by T reg cells.
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(1997)
Curr Opin Immunol
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, pp. 872-883
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O'Garra, A.1
Steinman, L.2
Gijbels, K.3
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43
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0030442723
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The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients
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Saoudi A, Seddon B, Fowell D, Mason D. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients. J Exp Med. 184:1996;2393-2398.
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J Exp Med
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Saoudi, A.1
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Fowell, D.3
Mason, D.4
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45
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0031831379
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In vivo expression of a TCR antagonist: T cells escape central tolerance but are antagonized in the periphery
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of outstanding interest. This report shows that T cells recognising a peptide as an antagonist are not deleted by that peptide in the thymus but respond to it as an antagonist in the periphery. It suggests a possible role for self antagonist peptides in the control of autoimmunity.
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Williams CB, Vidal K, Donermeyer D, Peterson DA, White JM, Allen PM. In vivo expression of a TCR antagonist: T cells escape central tolerance but are antagonized in the periphery. of outstanding interest J Immunol. 161:1998;128-137 This report shows that T cells recognising a peptide as an antagonist are not deleted by that peptide in the thymus but respond to it as an antagonist in the periphery. It suggests a possible role for self antagonist peptides in the control of autoimmunity.
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(1998)
J Immunol
, vol.161
, pp. 128-137
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Williams, C.B.1
Vidal, K.2
Donermeyer, D.3
Peterson, D.A.4
White, J.M.5
Allen, P.M.6
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46
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0027941138
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Oral tolerance to myelin basic protein induces regulatory TGF-beta-secreting T cells in Peyer's patches of SJL mice
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Santos LM, al-Sabbagh A, Londono A, Weiner HL. Oral tolerance to myelin basic protein induces regulatory TGF-beta-secreting T cells in Peyer's patches of SJL mice. Cell Immunol. 157:1994;439-447.
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Cell Immunol
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Santos, L.M.1
Al-Sabbagh, A.2
Londono, A.3
Weiner, H.L.4
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47
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0032525034
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In situ immune response in gut-associated lymphoid tissue (GALT) following oral antigen in TCR-transgenic mice
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of special interest. The authors provide a quantitative analysis of the induction of cytokines in vivo.
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Gonnella PA, Chen Y, Inobe J, Komagata Y, Quartulli M, Weiner HL. In situ immune response in gut-associated lymphoid tissue (GALT) following oral antigen in TCR-transgenic mice. of special interest J Immunol. 160:1998;4708-4718 The authors provide a quantitative analysis of the induction of cytokines in vivo.
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