메뉴 건너뛰기




Volumn 60, Issue 2, 2003, Pages 117-129

Reduced folate carrier: Biochemistry and molecular biology of the normal and methotrexate-resistant cell

Author keywords

Drug resistance; Folic acid; Methotrexate; Molecular biology

Indexed keywords

FOLIC ACID; FOLIC ACID ANTAGONIST; METHOTREXATE; REDUCED FOLATE CARRIER;

EID: 0038779673     PISSN: 09674845     EISSN: None     Source Type: Journal    
DOI: 10.1080/09674845.2003.11783687     Document Type: Article
Times cited : (22)

References (76)
  • 1
    • 0033805360 scopus 로고    scopus 로고
    • A polymoprhism (80G-A) in the reduced folate carrier gene and its association with folate status and homocysteinema
    • Chango A, Emery-Fillon N, Potier de Courcy G et al. A polymoprhism (80G-A) in the reduced folate carrier gene and its association with folate status and homocysteinema. Mol Genet Metab 2000; 70: 310-5.
    • (2000) Mol Genet Metab , vol.70 , pp. 310-315
    • Chango, A.1    Emery-Fillon, N.2    Potier De Courcy, G.3
  • 4
    • 0035797082 scopus 로고    scopus 로고
    • Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis
    • Wang Y, Zhao R, Russell RG, Goldman D. Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis. Biochim Biophys Acta 2000; 1513: 49-54.
    • (2000) Biochim Biophys Acta , vol.1513 , pp. 49-54
    • Wang, Y.1    Zhao, R.2    Russell, R.G.3    Goldman, D.4
  • 5
    • 0034282991 scopus 로고    scopus 로고
    • Transport of amphipathic anions by human multidrug resistance protein 3
    • Zeng H, Liu G, Rea PA, Kruh GD. Transport of amphipathic anions by human multidrug resistance protein 3. Cancer Res 2000; 60: 4779-84.
    • (2000) Cancer Res , vol.60 , pp. 4779-4784
    • Zeng, H.1    Liu, G.2    Rea, P.A.3    Kruh, G.D.4
  • 6
    • 0033967579 scopus 로고    scopus 로고
    • Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells
    • Drori S, Sprecher H, Shemer G, Jansen G, Goldman ID, Assaraf YG. Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells. Eur J Biochem 2000; 267: 690-702.
    • (2000) Eur J Biochem , vol.267 , pp. 690-702
    • Drori, S.1    Sprecher, H.2    Shemer, G.3    Jansen, G.4    Goldman, I.D.5    Assaraf, Y.G.6
  • 7
    • 0026675617 scopus 로고
    • Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia
    • Trippett T, Schlemmer S, Elisseyeff Y et al. Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia. Blood 1992; 80: 1158-62.
    • (1992) Blood , vol.80 , pp. 1158-1162
    • Trippett, T.1    Schlemmer, S.2    Elisseyeff, Y.3
  • 8
    • 0033008151 scopus 로고    scopus 로고
    • Therapuetic strategies targeting proteins that regulate folate and reduced folate transport
    • Trippett TM, Bertino JR. Therapuetic strategies targeting proteins that regulate folate and reduced folate transport. J Chemother 1999; 11: 3-10.
    • (1999) J Chemother , vol.11 , pp. 3-10
    • Trippett, T.M.1    Bertino, J.R.2
  • 9
    • 0028008481 scopus 로고
    • Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells
    • Brigle KE, Spinella MJ, Westin EH, Goldman ID. Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells. Biochem Pharmacol 1994; 47: 337-45.
    • (1994) Biochem Pharmacol , vol.47 , pp. 337-345
    • Brigle, K.E.1    Spinella, M.J.2    Westin, E.H.3    Goldman, I.D.4
  • 10
    • 0026446685 scopus 로고
    • Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates
    • Wang X, Shen F, Freisheim JH, Gentry LE, Ratnam M. Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates. Biochem Pharmacol 1992; 44: 1898-1901.
    • (1992) Biochem Pharmacol , vol.44 , pp. 1898-1901
    • Wang, X.1    Shen, F.2    Freisheim, J.H.3    Gentry, L.E.4    Ratnam, M.5
  • 11
    • 85039655667 scopus 로고    scopus 로고
    • Solute carrier family 19, member 1: SLC19A1
    • Johns Hopkins University
    • McKusick VA. Solute carrier family 19, member 1: SLC19A1. Medelian inheritance in Man. Johns Hopkins University. 〈http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600424〉
    • Medelian Inheritance in Man
    • McKusick, V.A.1
  • 12
    • 0026068379 scopus 로고
    • Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: Role of carrier- and receptor-mediated transport systems
    • Westerhof GR, Jansen G, van Emmerik N et al. Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems. Cancer Res 1991; 51: 5507-13.
    • (1991) Cancer Res , vol.51 , pp. 5507-5513
    • Westerhof, G.R.1    Jansen, G.2    Van Emmerik, N.3
  • 13
    • 0027058186 scopus 로고
    • Effects of folate receptor expression following stable transfection into wild type and methotrexate transport-deficient ZR-75-1 human breast cancer cells
    • Dixon KH, Mulligan T, Chung K-N, Elwood PC, Cowan KH. Effects of folate receptor expression following stable transfection into wild type and methotrexate transport-deficient ZR-75-1 human breast cancer cells J Biol Chem 1992; 267: 24140-7.
    • (1992) J Biol Chem , vol.267 , pp. 24140-24147
    • Dixon, K.H.1    Mulligan, T.2    Chung, K.-N.3    Elwood, P.C.4    Cowan, K.H.5
  • 14
    • 0032936786 scopus 로고    scopus 로고
    • Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates
    • Sierra EE, Goldman ID. Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates. Semin Oncol 1999; 26 (Suppl 6): 11-23.
    • (1999) Semin Oncol , vol.26 , Issue.SUPPL. 6 , pp. 11-23
    • Sierra, E.E.1    Goldman, I.D.2
  • 15
    • 0035204297 scopus 로고    scopus 로고
    • Expression of the reduced folate carrier SLC19A1 in IEC-6 cells result in two distinct transport activities
    • Rajgopal A, Sierra EE, Zhao R, Goldman ID. Expression of the reduced folate carrier SLC19A1 in IEC-6 cells result in two distinct transport activities. Am J Physiol Cell Physiol 2001; 281: C1579-C1586.
    • (2001) Am J Physiol Cell Physiol , vol.281
    • Rajgopal, A.1    Sierra, E.E.2    Zhao, R.3    Goldman, I.D.4
  • 16
    • 0035266190 scopus 로고    scopus 로고
    • Localization of a human reduced folate carrier protein in the mitochondrial as well as the cell membrane of leukemia cells
    • Trippett TM, Garcia S, Manova K et al. Localization of a human reduced folate carrier protein in the mitochondrial as well as the cell membrane of leukemia cells. Cancer Res 2001; 61: 1941-7.
    • (2001) Cancer Res , vol.61 , pp. 1941-1947
    • Trippett, T.M.1    Garcia, S.2    Manova, K.3
  • 18
    • 0032525856 scopus 로고    scopus 로고
    • Transcript heterogeneity of the human reduced folate carrier results from the use of multiple promoters and variable splicing of alternative upstream exons
    • Zhang L, Wong SC, Matherly LH. Transcript heterogeneity of the human reduced folate carrier results from the use of multiple promoters and variable splicing of alternative upstream exons. Biochem J 1998; 332: 773-80.
    • (1998) Biochem J , vol.332 , pp. 773-780
    • Zhang, L.1    Wong, S.C.2    Matherly, L.H.3
  • 19
    • 0028887425 scopus 로고
    • Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake
    • Williams FMR, Flintoff WF. Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. J Biol Chem 1995; 270: 2987-92.
    • (1995) J Biol Chem , vol.270 , pp. 2987-2992
    • Williams, F.M.R.1    Flintoff, W.F.2
  • 20
    • 0033057285 scopus 로고    scopus 로고
    • Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis
    • Zhao R, Sharina IG, Goldmann ID. Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis. Mol Pharmacol 1999; 56: 68-76.
    • (1999) Mol Pharmacol , vol.56 , pp. 68-76
    • Zhao, R.1    Sharina, I.G.2    Goldmann, I.D.3
  • 21
    • 0029147794 scopus 로고
    • Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells
    • Moscow JA, Gong M, He R et al. Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res 1995; 55: 3790-4.
    • (1995) Cancer Res , vol.55 , pp. 3790-3794
    • Moscow, J.A.1    Gong, M.2    He, R.3
  • 22
    • 0027982786 scopus 로고
    • A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells
    • Dixon KH, Lampher BC, Chiu J, Kelly K, Cowan KH. A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. J Biol Chem 1994; 269: 17-20.
    • (1994) J Biol Chem , vol.269 , pp. 17-20
    • Dixon, K.H.1    Lampher, B.C.2    Chiu, J.3    Kelly, K.4    Cowan, K.H.5
  • 23
    • 0035448301 scopus 로고    scopus 로고
    • Functional interaction between arginine-133 and aspartate-88 in the human reduced folate carrier: Evidence for a charge-pair association
    • Liu XY, Matherly LH. Functional interaction between arginine-133 and aspartate-88 in the human reduced folate carrier: evidence for a charge-pair association. Biochem J 2001; 358: 511-6.
    • (2001) Biochem J , vol.358 , pp. 511-516
    • Liu, X.Y.1    Matherly, L.H.2
  • 24
    • 0035230890 scopus 로고    scopus 로고
    • Molecular and cellular biology of the human reduced folate carrier
    • Matherly LH. Molecular and cellular biology of the human reduced folate carrier. Prog Nucleic Acid Res Mol Biol 2001; 67: 131-62.
    • (2001) Prog Nucleic Acid Res Mol Biol , vol.67 , pp. 131-162
    • Matherly, L.H.1
  • 25
    • 0029084385 scopus 로고
    • Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective chinese hamster ovary cells
    • Wong SC, Proefke SA, Bhushan A, Matherly LH. Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective chinese hamster ovary cells. J Biol Chem 1995; 270: 17468-75.
    • (1995) J Biol Chem , vol.270 , pp. 17468-17475
    • Wong, S.C.1    Proefke, S.A.2    Bhushan, A.3    Matherly, L.H.4
  • 26
    • 0033523092 scopus 로고    scopus 로고
    • Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion
    • Ferguson PL, Flintoff WF. Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion. J Biol Chem 1999; 274: 16269-78.
    • (1999) J Biol Chem , vol.274 , pp. 16269-16278
    • Ferguson, P.L.1    Flintoff, W.F.2
  • 27
    • 0037097024 scopus 로고    scopus 로고
    • Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function
    • Sadlish H, Williams FM, Flintoff WF. Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function. Biochem J 2002; 364: 777-86.
    • (2002) Biochem J , vol.364 , pp. 777-786
    • Sadlish, H.1    Williams, F.M.2    Flintoff, W.F.3
  • 28
    • 85039660953 scopus 로고    scopus 로고
    • Restoration of high-level transport activity by human reduced folate carrier/ThTr1 chimeric transporters: Role of the transmembrane domain 6/7 linker region in reduced folate carrier protein
    • ePublished: BJ20020419
    • Liu XY, Witt TL, Matherly LH. Restoration of high-level transport activity by human reduced folate carrier/ThTr1 chimeric transporters: role of the transmembrane domain 6/7 linker region in reduced folate carrier protein. Biochem J (ePublished: BJ20020419).
    • Biochem J
    • Liu, X.Y.1    Witt, T.L.2    Matherly, L.H.3
  • 29
    • 0028346146 scopus 로고
    • Role of N-glycosylation in the structure and fucntion of the methotrexate membrane transporter from CCRF-CEM human lymphoblastic cells
    • Matherly LH, Angeles SH. Role of N-glycosylation in the structure and fucntion of the methotrexate membrane transporter from CCRF-CEM human lymphoblastic cells. Biochem Pharmacol 1994; 47: 1094-8.
    • (1994) Biochem Pharmacol , vol.47 , pp. 1094-1098
    • Matherly, L.H.1    Angeles, S.H.2
  • 30
    • 0032532415 scopus 로고    scopus 로고
    • Effects of the loss of capacity for N-glycoslylation on the transport activity and cellular localization of the human reduced folate carrier
    • Wong SC, Zhang L, Proefke SA, Matherly LH. Effects of the loss of capacity for N-glycoslylation on the transport activity and cellular localization of the human reduced folate carrier. Biochim Biophys Acta 1998; 1375: 6-12.
    • (1998) Biochim Biophys Acta , vol.1375 , pp. 6-12
    • Wong, S.C.1    Zhang, L.2    Proefke, S.A.3    Matherly, L.H.4
  • 31
    • 0033782030 scopus 로고    scopus 로고
    • Dynamics and retention of misfolded proteins in native ER membranes
    • Nehls S, Snapp EL,Cole NB et al. Dynamics and retention of misfolded proteins in native ER membranes. Nat Cell Biol 2000; 2: 288-95.
    • (2000) Nat Cell Biol , vol.2 , pp. 288-295
    • Nehls, S.1    Snapp, E.L.2    Cole, N.B.3
  • 32
    • 0032054315 scopus 로고    scopus 로고
    • Construction of a 2.5-Mb integrated physical and gene map of distal 21q22.3
    • Lapenta V, Sossi V, Gosset P et al. Construction of a 2.5-Mb integrated physical and gene map of distal 21q22.3. Genomics 1998; 49: 1-13.
    • (1998) Genomics , vol.49 , pp. 1-13
    • Lapenta, V.1    Sossi, V.2    Gosset, P.3
  • 33
    • 0039311993 scopus 로고    scopus 로고
    • Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5′ end heterogeneity
    • Tolner B, Roy K, Sirotnak FM. Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5′ end heterogeneity. Gene 1998; 211: 331-41.
    • (1998) Gene , vol.211 , pp. 331-341
    • Tolner, B.1    Roy, K.2    Sirotnak, F.M.3
  • 34
    • 0027963626 scopus 로고
    • Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake
    • Williams FMR, Murray RC, Underhill M, Flintoff WF. Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake. J Biol Chem 1994; 269: 5810-6.
    • (1994) J Biol Chem , vol.269 , pp. 5810-5816
    • Williams, F.M.R.1    Murray, R.C.2    Underhill, M.3    Flintoff, W.F.4
  • 35
    • 0032807628 scopus 로고    scopus 로고
    • Isolation and characterization of genomic sequence involved in the regulation of the human reduced folate carrier gene (RFC1)
    • Gong M, Cowan KH, Gudas J, Moscow JA. Isolation and characterization of genomic sequence involved in the regulation of the human reduced folate carrier gene (RFC1). Gene 1999; 233: 21-31.
    • (1999) Gene , vol.233 , pp. 21-31
    • Gong, M.1    Cowan, K.H.2    Gudas, J.3    Moscow, J.A.4
  • 36
    • 0036846897 scopus 로고    scopus 로고
    • The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: Identification of seven non-coding exons and characterization of a novel promoter
    • Whetstine JR, Flatley RM, Matherly LH. The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter. Biochem J 2002; 367: 629-40.
    • (2002) Biochem J , vol.367 , pp. 629-640
    • Whetstine, J.R.1    Flatley, R.M.2    Matherly, L.H.3
  • 37
    • 0030895504 scopus 로고    scopus 로고
    • Organization, structure and alternate splicing of the murine RFC-1 gene encoding a folate transporter
    • Tolner B, Roy K, Sirotnak F M. Organization, structure and alternate splicing of the murine RFC-1 gene encoding a folate transporter. Gene 1997; 189: 1-7.
    • (1997) Gene , vol.189 , pp. 1-7
    • Tolner, B.1    Roy, K.2    Sirotnak, F.M.3
  • 38
    • 0025016121 scopus 로고
    • Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier
    • Jansen G, Westerhoff GR, Jarmuszewski MJA, Kathmann I, Rijksen G, Schornagel JH. Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. J Biol Chem 1990; 265: 18272-7.
    • (1990) J Biol Chem , vol.265 , pp. 18272-18277
    • Jansen, G.1    Westerhoff, G.R.2    Jarmuszewski, M.J.A.3    Kathmann, I.4    Rijksen, G.5    Schornagel, J.H.6
  • 39
    • 0035794180 scopus 로고    scopus 로고
    • The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element
    • Whetstine JR, Matherly LH. The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element. J Biol Chem 2001; 276: 6350-8.
    • (2001) J Biol Chem , vol.276 , pp. 6350-6358
    • Whetstine, J.R.1    Matherly, L.H.2
  • 40
    • 0346037346 scopus 로고    scopus 로고
    • The human reduced folate carrier gene is regulated by the AP2 and Sp1 transcription factor families and a functional 61 base pair polymorphism
    • ePublished: M208296200
    • Whetstine JR, Witt TL, Matherly LH. The human reduced folate carrier gene is regulated by the AP2 and Sp1 transcription factor families and a functional 61 base pair polymorphism. J Biol Chem 2002 (ePublished: M208296200).
    • (2002) J Biol Chem
    • Whetstine, J.R.1    Witt, T.L.2    Matherly, L.H.3
  • 42
    • 0034192628 scopus 로고    scopus 로고
    • Regulation and function of the p53-related proteins: Same family different rules
    • Lohrum MAE, Vousden KH. Regulation and function of the p53-related proteins: same family different rules. Trends Cell Biol 2000; 10: 197-202.
    • (2000) Trends Cell Biol , vol.10 , pp. 197-202
    • Lohrum, M.A.E.1    Vousden, K.H.2
  • 43
    • 0032497805 scopus 로고    scopus 로고
    • Structure and organization of the human reduced folate carrier gene
    • Zhang L, Wong SC, Matherly LH. Structure and organization of the human reduced folate carrier gene. Biochem Biophys Acta 1998; 1442: 389-93.
    • (1998) Biochem Biophys Acta , vol.1442 , pp. 389-393
    • Zhang, L.1    Wong, S.C.2    Matherly, L.H.3
  • 44
    • 0030790240 scopus 로고    scopus 로고
    • Organization of the murine reduced folate carrier gene and identification of variant splice forms
    • Brigle KE, Spinella MJ, Sierra EE, Goldman ID. Organization of the murine reduced folate carrier gene and identification of variant splice forms. Biochem Biophys Acta 1997; 1353: 191-8.
    • (1997) Biochem Biophys Acta , vol.1353 , pp. 191-198
    • Brigle, K.E.1    Spinella, M.J.2    Sierra, E.E.3    Goldman, I.D.4
  • 45
    • 15144346421 scopus 로고    scopus 로고
    • A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance
    • Jansen G, Mauritz R, Drori S et al. A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. J Biol Chem 1998; 273: 30189-98.
    • (1998) J Biol Chem , vol.273 , pp. 30189-30198
    • Jansen, G.1    Mauritz, R.2    Drori, S.3
  • 46
    • 0037800789 scopus 로고
    • Haematology
    • McLactchey KD, ed. London: Williams and Wilkins
    • Hanson CA. Haematology. In: McLactchey KD, ed. Clinical laboratory medicine. London: Williams and Wilkins, 1994: 817-63, 939-69.
    • (1994) Clinical Laboratory Medicine , pp. 817-863
    • Hanson, C.A.1
  • 48
    • 0034051298 scopus 로고    scopus 로고
    • Methotrexate resistance in relapsed childhood acute lymphoblastic leukaemia
    • Rots MG, Pieters R, Peters GJ et al. Methotrexate resistance in relapsed childhood acute lymphoblastic leukaemia. Br J Haematol 2000; 109: 629-34.
    • (2000) Br J Haematol , vol.109 , pp. 629-634
    • Rots, M.G.1    Pieters, R.2    Peters, G.J.3
  • 49
    • 42049086426 scopus 로고
    • Acute lymphocytic leukemia
    • Beutler E, Lichtman M A, Coller BS, Kipps TJ, eds. New York: McGraw Hill: Chapter
    • Mauer AM. Acute lymphocytic leukemia. In: Beutler E, Lichtman M A, Coller BS, Kipps TJ, eds. William's hematology (5th Ed). New York: McGraw Hill, 1995: Chapter 105.
    • (1995) William's Hematology (5th Ed) , pp. 105
    • Mauer, A.M.1
  • 50
    • 0032572912 scopus 로고    scopus 로고
    • Acute lymphoblastic leukaemia
    • Pui C-H, Evans WE. Acute lymphoblastic leukaemia. N Engl J Med 1998; 339: 605-15.
    • (1998) N Engl J Med , vol.339 , pp. 605-615
    • Pui, C.-H.1    Evans, W.E.2
  • 51
    • 0035866386 scopus 로고    scopus 로고
    • Methotrexate accumulates to similar levels in animals transplanted with normal versus drug-resistant transgenic marrow
    • Belur LR, Boelk-Galvan D, Diers MD, McIvor RS, Zimmerman CL. Methotrexate accumulates to similar levels in animals transplanted with normal versus drug-resistant transgenic marrow. Cancer Res 2001; 61: 1522-6.
    • (2001) Cancer Res , vol.61 , pp. 1522-1526
    • Belur, L.R.1    Boelk-Galvan, D.2    Diers, M.D.3    McIvor, R.S.4    Zimmerman, C.L.5
  • 52
    • 0018148658 scopus 로고
    • Membrane transport of methotrexate in human lymphoblastoid cells
    • Warren RD, Nichols AP, Bender RA. Membrane transport of methotrexate in human lymphoblastoid cells. Cancer Res 1978; 38: 668-71.
    • (1978) Cancer Res , vol.38 , pp. 668-671
    • Warren, R.D.1    Nichols, A.P.2    Bender, R.A.3
  • 54
    • 0031976589 scopus 로고    scopus 로고
    • In vitro mutations in dihydrofolate reductase that confers resistance to methotrexate: Potential for clinical application
    • Blakley R L, Sorrentino B P. In vitro mutations in dihydrofolate reductase that confers resistance to methotrexate: Potential for clinical application. Hum Mutat 1998; 11: 259-63.
    • (1998) Hum Mutat , vol.11 , pp. 259-263
    • Blakley, R.L.1    Sorrentino, B.P.2
  • 55
    • 0015894654 scopus 로고
    • Transport of methotrexate into normal haemopoietic cells and into leukaemic cells and its effects on DNA synthesis
    • Hoffbrand AV, Tripp E, Catovsky D, Das KC. Transport of methotrexate into normal haemopoietic cells and into leukaemic cells and its effects on DNA synthesis. Br J Haematol 1973; 25: 497-511.
    • (1973) Br J Haematol , vol.25 , pp. 497-511
    • Hoffbrand, A.V.1    Tripp, E.2    Catovsky, D.3    Das, K.C.4
  • 56
    • 0030034467 scopus 로고    scopus 로고
    • Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo, a rationale for high-dose methotrexate
    • Masson E, Relling MV, Synold TW et al. Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo, a rationale for high-dose methotrexate. J Clin Invest 1996; 97: 73-80.
    • (1996) J Clin Invest , vol.97 , pp. 73-80
    • Masson, E.1    Relling, M.V.2    Synold, T.W.3
  • 57
    • 0034163511 scopus 로고    scopus 로고
    • Mutations in the reduced-folate carrier affect protein localization and stability
    • Sadlish H, Murray RC, Williams MR, Flintoff WF. Mutations in the reduced-folate carrier affect protein localization and stability. Biochem J 2000; 346: 509-18.
    • (2000) Biochem J , vol.346 , pp. 509-518
    • Sadlish, H.1    Murray, R.C.2    Williams, M.R.3    Flintoff, W.F.4
  • 58
    • 0030984299 scopus 로고    scopus 로고
    • Molecular mechanism of antifolate transporter-deficiency in a methotrexate-resistant MOLT-3 human leukemia cell line
    • Gong M, Yess J, Connolly T et al. Molecular mechanism of antifolate transporter-deficiency in a methotrexate-resistant MOLT-3 human leukemia cell line. Blood 1997; 89: 2494-9.
    • (1997) Blood , vol.89 , pp. 2494-2499
    • Gong, M.1    Yess, J.2    Connolly, T.3
  • 59
    • 0021844160 scopus 로고
    • Evolution of methotrexate resistance of human acute lymphoblastic leukemia cell in vitro
    • Ohnuma T, Lo RJ, Scanlon KJ et al. Evolution of methotrexate resistance of human acute lymphoblastic leukemia cell in vitro. Cancer Res 1985; 45: 1815-22.
    • (1985) Cancer Res , vol.45 , pp. 1815-1822
    • Ohnuma, T.1    Lo, R.J.2    Scanlon, K.J.3
  • 60
    • 0034872907 scopus 로고    scopus 로고
    • Folate homeostasis and antiproliferative activity of folates and antifolates
    • Peters GJ, Jansen G. Folate homeostasis and antiproliferative activity of folates and antifolates. Nutrition 2001; 17: 737-8.
    • (2001) Nutrition , vol.17 , pp. 737-738
    • Peters, G.J.1    Jansen, G.2
  • 61
    • 0031669954 scopus 로고    scopus 로고
    • Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: Relationship to immunophenotype and ploidy
    • Zhang L, Taub JW, Williamson M et al. Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy. Clin Cancer Res 1998; 4: 2169-77.
    • (1998) Clin Cancer Res , vol.4 , pp. 2169-2177
    • Zhang, L.1    Taub, J.W.2    Williamson, M.3
  • 62
    • 0035868656 scopus 로고    scopus 로고
    • Association of deletions and translocations of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia
    • Ding BC, Witt TL, Hukku B, Heng H, Zang L, Matherly LH. Association of deletions and translocations of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia. Biochem Pharmacol 2001; 61: 665-75.
    • (2001) Biochem Pharmacol , vol.61 , pp. 665-675
    • Ding, B.C.1    Witt, T.L.2    Hukku, B.3    Heng, H.4    Zang, L.5    Matherly, L.H.6
  • 63
    • 0030948473 scopus 로고    scopus 로고
    • Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression
    • Gorlick R, Goker E, Trippett T et al. Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression. Blood 1997; 89: 1013-8.
    • (1997) Blood , vol.89 , pp. 1013-1018
    • Gorlick, R.1    Goker, E.2    Trippett, T.3
  • 64
    • 0036844903 scopus 로고    scopus 로고
    • Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines
    • Rothem L, Ifergan I, Kaufman Y, Priest DG, Jansen G, Assaraf YG. Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines. Biochem J 2002; 367: 741-50.
    • (2002) Biochem J , vol.367 , pp. 741-750
    • Rothem, L.1    Ifergan, I.2    Kaufman, Y.3    Priest, D.G.4    Jansen, G.5    Assaraf, Y.G.6
  • 65
    • 0033537838 scopus 로고    scopus 로고
    • Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier
    • Wong SC, Zhang L, Witt TK, Proefke SA, Bhushan A, Matherly LH. Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier. J Biol Chem 1999; 274: 10388-94.
    • (1999) J Biol Chem , vol.274 , pp. 10388-10394
    • Wong, S.C.1    Zhang, L.2    Witt, T.K.3    Proefke, S.A.4    Bhushan, A.5    Matherly, L.H.6
  • 66
    • 0032563287 scopus 로고    scopus 로고
    • A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function
    • Zhao R, Assaraf YG, Goldmann ID. A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function. J Biol Chem 1998; 273: 19065-71.
    • (1998) J Biol Chem , vol.273 , pp. 19065-19071
    • Zhao, R.1    Assaraf, Y.G.2    Goldmann, I.D.3
  • 67
    • 0036828910 scopus 로고    scopus 로고
    • Functional role of arginine 373 in substrate translocation by the reduce folate carrier
    • Sadlish H, Williams FMR, Flintoff WF. Functional role of arginine 373 in substrate translocation by the reduce folate carrier. J Biol Chem 2002; 277: 42105-12.
    • (2002) J Biol Chem , vol.277 , pp. 42105-42112
    • Sadlish, H.1    Williams, F.M.R.2    Flintoff, W.F.3
  • 68
    • 0032478826 scopus 로고    scopus 로고
    • A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate
    • Zhao R, Assaraf YG, Goldmann ID. A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate. J Biol Chem 1998; 273: 7873-9.
    • (1998) J Biol Chem , vol.273 , pp. 7873-7879
    • Zhao, R.1    Assaraf, Y.G.2    Goldmann, I.D.3
  • 69
    • 0035028014 scopus 로고    scopus 로고
    • Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier
    • Sharina IG, Zhao R, Wang Y, Babani S, Goldman ID. Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier. Mol Pharmacol 2001; 59: 1022-8.
    • (2001) Mol Pharmacol , vol.59 , pp. 1022-1028
    • Sharina, I.G.1    Zhao, R.2    Wang, Y.3    Babani, S.4    Goldman, I.D.5
  • 70
    • 0033975105 scopus 로고    scopus 로고
    • Role of the amino acid 45 residue in reduced folate carrier function and ion-dependent transport as characterized by site-directed mutagenesis
    • Zhao R, Gao F, Wang PJ, Goldmann ID. Role of the amino acid 45 residue in reduced folate carrier function and ion-dependent transport as characterized by site-directed mutagenesis. Mol Pharmacol 2000; 57: 317-23.
    • (2000) Mol Pharmacol , vol.57 , pp. 317-323
    • Zhao, R.1    Gao, F.2    Wang, P.J.3    Goldmann, I.D.4
  • 71
    • 0032475923 scopus 로고    scopus 로고
    • Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate
    • Tse A, Brigle K, Taylor SM, Moran RG. Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate. J Biol Chem 1998; 273: 25953-60.
    • (1998) J Biol Chem , vol.273 , pp. 25953-25960
    • Tse, A.1    Brigle, K.2    Taylor, S.M.3    Moran, R.G.4
  • 72
    • 0032579517 scopus 로고    scopus 로고
    • A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues
    • Roy K, Tolner B, Chiao JH, Sirotnak FM. A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. J Biol Chem 1998; 273: 2526-31.
    • (1998) J Biol Chem , vol.273 , pp. 2526-2531
    • Roy, K.1    Tolner, B.2    Chiao, J.H.3    Sirotnak, F.M.4
  • 73
    • 0032865378 scopus 로고    scopus 로고
    • Descrimination among reduced folates and methotrexate as transport substrate by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier
    • Zhao R, Gao F, Goldmann ID. Descrimination among reduced folates and methotrexate as transport substrate by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier. Biochem Pharmacol 1999; 58: 1615-24.
    • (1999) Biochem Pharmacol , vol.58 , pp. 1615-1624
    • Zhao, R.1    Gao, F.2    Goldmann, I.D.3
  • 75
    • 17744385728 scopus 로고    scopus 로고
    • mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized template-based RT-PCR method
    • Rots MG, Willey JC, Jansen G et al. mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized template-based RT-PCR method. Leukemia 2000; 14: 2166-75.
    • (2000) Leukemia , vol.14 , pp. 2166-2175
    • Rots, M.G.1    Willey, J.C.2    Jansen, G.3
  • 76
    • 0036400916 scopus 로고    scopus 로고
    • The murine-reduced folate carrier gene can act as a selectable marker and suicide gene in hematopoietic cells in vivo
    • Liu S, Song L, Bevins R, Birhiray O, Moscow JA. The murine-reduced folate carrier gene can act as a selectable marker and suicide gene in hematopoietic cells in vivo. Hum Gene Ther 2002; 13: 1777-82.
    • (2002) Hum Gene Ther , vol.13 , pp. 1777-1782
    • Liu, S.1    Song, L.2    Bevins, R.3    Birhiray, O.4    Moscow, J.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.