Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier

Biochemical Pharmacology

Volumn 58, Issue 10, 1999, Pages 1615-1624

  Zhao, Rongbao ^a   Gao, Feng ^a   Goldman, I David ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

anticancer drug resistance; Antifolates; Carrier mediated transport; Folates; Major Facilitator Superfamily; Reduced folate carrier

Indexed keywords

DRUG CARRIER; FOLIC ACID; METHOTREXATE; PHENYLALANINE; SERINE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING AND TRANSPORT; DRUG RESISTANCE; DRUG TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL DIVISION; CHLORIDES; DNA MUTATIONAL ANALYSIS; DNA, COMPLEMENTARY; DNA, NEOPLASM; DRUG RESISTANCE, NEOPLASM; KINETICS; LEUCOVORIN; LEUKEMIA L1210; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; MICE; PHENOTYPE; PHENYLALANINE; SERINE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032865378     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00257-9     Document Type: Article

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