-
1
-
-
0021838288
-
The cellular pharmacology of methotrexate
-
Goldman, I. D., and Matherly, L. H. The cellular pharmacology of methotrexate. Pharmacol. Ther., 28: 77-102, 1985.
-
(1985)
Pharmacol. Ther.
, vol.28
, pp. 77-102
-
-
Goldman, I.D.1
Matherly, L.H.2
-
2
-
-
0022353539
-
Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: Biological significance and implications of improved therapy of human cancer
-
Sirotnak, F. M. Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: biological significance and implications of improved therapy of human cancer. Cancer Res., 45: 3992-4000, 1985.
-
(1985)
Cancer Res.
, vol.45
, pp. 3992-4000
-
-
Sirotnak, F.M.1
-
3
-
-
0019848289
-
Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate resistant L1210 clonal lines derived in vivo
-
Sirotnak, F. M., Moccio, D. M., Kelleher, L. E., and Goutas, L. J. Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate resistant L1210 clonal lines derived in vivo. Cancer Res., 41: 4447-4452, 1981.
-
(1981)
Cancer Res.
, vol.41
, pp. 4447-4452
-
-
Sirotnak, F.M.1
Moccio, D.M.2
Kelleher, L.E.3
Goutas, L.J.4
-
4
-
-
0029962417
-
Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia
-
Matherly, L. H., and Taub, J. W. Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia. Leukemia Lymphoma, 21: 359-368, 1996.
-
(1996)
Leukemia Lymphoma
, vol.21
, pp. 359-368
-
-
Matherly, L.H.1
Taub, J.W.2
-
5
-
-
0002972502
-
Acute lymphoblastic leukemia
-
P. A. Pizza and D. G. Poplack (eds.), Philadelphia: J. B. Lippincott Co.
-
Poplack, D. G. Acute lymphoblastic leukemia. In: P. A. Pizza and D. G. Poplack (eds.), Principles and Practice of Pediatric Oncology, pp. 431-481. Philadelphia: J. B. Lippincott Co., 1993.
-
(1993)
Principles and Practice of Pediatric Oncology
, pp. 431-481
-
-
Poplack, D.G.1
-
6
-
-
0030835804
-
Increased frequency of expression of elevated dihydrofolate reductase in T-cell versus B-precursor acute lymphoblastic leukemia in children
-
Matherly, L. H., Taub, J. W., Wong, S. C., Simpson, P. M., Ekizian, E., Buck, S., Williamson, M., Amylon, M., Pullen, J., Camilla, B., and Ravindranath, Y. Increased frequency of expression of elevated dihydrofolate reductase in T-cell versus B-precursor acute lymphoblastic leukemia in children. Blood, 90: 578-589, 1997.
-
(1997)
Blood
, vol.90
, pp. 578-589
-
-
Matherly, L.H.1
Taub, J.W.2
Wong, S.C.3
Simpson, P.M.4
Ekizian, E.5
Buck, S.6
Williamson, M.7
Amylon, M.8
Pullen, J.9
Camilla, B.10
Ravindranath, Y.11
-
7
-
-
0026675617
-
Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia
-
Trippelt, T., Schlemmer, S., Elisseyeff, Y., Goker, E., Wachter, M., Steinherz, P., Tan, C., Berman, E., Wright, J. E., Rosowsky, A., Schwitzer, B., and Bertino, J. R. Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia. Blood, 80: 1158-1162, 1992.
-
(1992)
Blood
, vol.80
, pp. 1158-1162
-
-
Trippelt, T.1
Schlemmer, S.2
Elisseyeff, Y.3
Goker, E.4
Wachter, M.5
Steinherz, P.6
Tan, C.7
Berman, E.8
Wright, J.E.9
Rosowsky, A.10
Schwitzer, B.11
Bertino, J.R.12
-
8
-
-
0030948473
-
Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphoblastic leukemia and is associated with decreased reduced folate carrier expression
-
Gorlick, R., Goker, E., Trippett, T., Steinherz, P., Elisseyeff, Y., Mazumdar, M., Flintoff, W. F., and Bertino, J. R. Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphoblastic leukemia and is associated with decreased reduced folate carrier expression. Blood, 89: 1013-1018, 1997.
-
(1997)
Blood
, vol.89
, pp. 1013-1018
-
-
Gorlick, R.1
Goker, E.2
Trippett, T.3
Steinherz, P.4
Elisseyeff, Y.5
Mazumdar, M.6
Flintoff, W.F.7
Bertino, J.R.8
-
9
-
-
0026560328
-
Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction
-
Horikoski, T., Danenberg, K. D, Stadlbauer, T. H. W., Volkenandt, M., Shea, L. C. C., Aigner, K., Gustavsson, B., Leichman, L., Frosing, R., Ray, M., Gibson, N. W., Spears, C. P., and Danenberg, P. V. Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res., 52: 108-116, 1992.
-
(1992)
Cancer Res.
, vol.52
, pp. 108-116
-
-
Horikoski, T.1
Danenberg, K.D.2
Stadlbauer, T.H.W.3
Volkenandt, M.4
Shea, L.C.C.5
Aigner, K.6
Gustavsson, B.7
Leichman, L.8
Frosing, R.9
Ray, M.10
Gibson, N.W.11
Spears, C.P.12
Danenberg, P.V.13
-
10
-
-
0028037401
-
Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction: Marked variation of expression among leukemia patients
-
Lenz, H. J., Danenberg, K., Schnieders, B., Goker, E., Peters, G. J., Garrow, T., Shane, B., Bertino, J. R., and Danenberg, P. V. Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction: marked variation of expression among leukemia patients. Oncol. Res., 6: 329-335, 1994.
-
(1994)
Oncol. Res.
, vol.6
, pp. 329-335
-
-
Lenz, H.J.1
Danenberg, K.2
Schnieders, B.3
Goker, E.4
Peters, G.J.5
Garrow, T.6
Shane, B.7
Bertino, J.R.8
Danenberg, P.V.9
-
11
-
-
0025115739
-
Quantitative analysis of MDR1 (mullidrug resistance) gene expression in human tumors by polymerase chain reaction
-
Noonan, K. E., Beck, C., Holzmayer, T. A., Chin, J. E., Wunder, J. S., Andrulis, I. L., Gazdar, A. F., Willman, C. L., Griffith, B., Von Hoff, D. D., and Roninson, I. B. Quantitative analysis of MDR1 (mullidrug resistance) gene expression in human tumors by polymerase chain reaction. Proc. Natl. Acad. Sci. USA, 87: 7160-7164, 1990.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 7160-7164
-
-
Noonan, K.E.1
Beck, C.2
Holzmayer, T.A.3
Chin, J.E.4
Wunder, J.S.5
Andrulis, I.L.6
Gazdar, A.F.7
Willman, C.L.8
Griffith, B.9
Von Hoff, D.D.10
Roninson, I.B.11
-
12
-
-
0028063423
-
Blast cell methotrexate polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia
-
Synold, T. W., Relling, M. V., Boyett, J. M., Rivera, G. K., Sandlund, J. T., Mahmoud, H., Crist, W. M., Pui, C. H., and Evans, W. E. Blast cell methotrexate polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia. J. Clin. Invest., 94: 1996-2001, 1994.
-
(1994)
J. Clin. Invest.
, vol.94
, pp. 1996-2001
-
-
Synold, T.W.1
Relling, M.V.2
Boyett, J.M.3
Rivera, G.K.4
Sandlund, J.T.5
Mahmoud, H.6
Crist, W.M.7
Pui, C.H.8
Evans, W.E.9
-
13
-
-
0026658557
-
Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (>50 chromosomes) B-lineage acute lymphoblastic leukemia: A Pediatric Oncology Group Study
-
Whitehead, V. M., Vuchich, M. J., Lauer, S. J., Mahoney, D., Carroll, A. J., Shuster, J. J., Esseltine, D. W., Payment, C., Look, A. T., Akabutu, J., Bowen, T., Taylor, L. D., Camitta, B., and Pullen, D. J. Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (>50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group Study. Blood, 80: 1316-1323, 1992.
-
(1992)
Blood
, vol.80
, pp. 1316-1323
-
-
Whitehead, V.M.1
Vuchich, M.J.2
Lauer, S.J.3
Mahoney, D.4
Carroll, A.J.5
Shuster, J.J.6
Esseltine, D.W.7
Payment, C.8
Look, A.T.9
Akabutu, J.10
Bowen, T.11
Taylor, L.D.12
Camitta, B.13
Pullen, D.J.14
-
14
-
-
3543012591
-
Accumulation of methotrexate polyglutamates (MTXPGS) in lymphoblasts, ploidy and trisomy of both chromosomes 4 and 10 in childhood B-progenitor cell acute lymphoblastic leukemia (ALL): A Pediatric Oncology Group study
-
Whitehead, V. M., Vuchich, M. J., Carroll, A. J., Lauer, S. J., Mahoney, D., Shuster, J. J., Payment, C., Koch, P. A., Akabutu, J. J., Bowen, T., Kamen, B. A., Ravindranath, Y., Emami, A., Beardsley, G. P., Pullen, D. J., and Camitta, B. Accumulation of methotrexate polyglutamates (MTXPGS) in lymphoblasts, ploidy and trisomy of both chromosomes 4 and 10 in childhood B-progenitor cell acute lymphoblastic leukemia (ALL): a Pediatric Oncology Group study. Blood, 84: 515a, 1994.
-
(1994)
Blood
, vol.84
-
-
Whitehead, V.M.1
Vuchich, M.J.2
Carroll, A.J.3
Lauer, S.J.4
Mahoney, D.5
Shuster, J.J.6
Payment, C.7
Koch, P.A.8
Akabutu, J.J.9
Bowen, T.10
Kamen, B.A.11
Ravindranath, Y.12
Emami, A.13
Beardsley, G.P.14
Pullen, D.J.15
Camitta, B.16
-
15
-
-
0020081481
-
Rapid formation of polyglutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cells
-
Fry, D. W., Yalowich, J. C., and Goldman, I. D. Rapid formation of polyglutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cells. J. Biol. Chem., 257: 1890-1896, 1982.
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 1890-1896
-
-
Fry, D.W.1
Yalowich, J.C.2
Goldman, I.D.3
-
16
-
-
0026474761
-
Characterization of transport-mediated methotrexate resistance in cultured human tumor cells with antibodies to the membrane carrier for methotrexate and tetrahydrofolate cofactors
-
Matherly, L. H., Angeles, S. M., and Czajkowski, C. A. Characterization of transport-mediated methotrexate resistance in cultured human tumor cells with antibodies to the membrane carrier for methotrexate and tetrahydrofolate cofactors. J. Biol. Chem., 267: 23253-23260, 1992.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 23253-23260
-
-
Matherly, L.H.1
Angeles, S.M.2
Czajkowski, C.A.3
-
17
-
-
0029084385
-
Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport defective Chinese hamster ovary cells
-
Wong, S. C., Proefke, S. A, Bhushan, A., and Matherly, L. H. Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport defective Chinese hamster ovary cells. J. Biol. Chem., 279: 17468-17457, 1995.
-
(1995)
J. Biol. Chem.
, vol.279
, pp. 17468-117457
-
-
Wong, S.C.1
Proefke, S.A.2
Bhushan, A.3
Matherly, L.H.4
-
18
-
-
0027477992
-
Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase
-
Duch, D. S., Banks, S., Dev, I. K., Dickerson, S. H., Ferone, R., Heath, L. S., Humphreys, J., Knick, V., Pendergest, W., Singer, S., Smith, G. K., Waters, K., and Wilson, H. R. Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase. Cancer Res., 53: 810-818, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 810-818
-
-
Duch, D.S.1
Banks, S.2
Dev, I.K.3
Dickerson, S.H.4
Ferone, R.5
Heath, L.S.6
Humphreys, J.7
Knick, V.8
Pendergest, W.9
Singer, S.10
Smith, G.K.11
Waters, K.12
Wilson, H.R.13
-
19
-
-
0032055906
-
Gene amplification and increased expression of the reduced folate carrier in transport elevated K562 cells
-
Wong, S. C., Zhang, L., Proefke, S. A., Hukku, B., and Matherly, L. H. Gene amplification and increased expression of the reduced folate carrier in transport elevated K562 cells. Biochem. Pharmacol., 55: 1135-1138, 1998.
-
(1998)
Biochem. Pharmacol.
, vol.55
, pp. 1135-1138
-
-
Wong, S.C.1
Zhang, L.2
Proefke, S.A.3
Hukku, B.4
Matherly, L.H.5
-
20
-
-
0000358981
-
Protocols for immunoaffinity purification
-
Cold Spring Harbor, NY: Cold Spring Harbor Laboratory
-
Harlowe, E., and Lane, D. (eds.). Protocols for immunoaffinity purification. In: Antibodies: A Laboratory Manual, p. 310. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1988.
-
(1988)
Antibodies: A Laboratory Manual
, pp. 310
-
-
Harlowe, E.1
Lane, D.2
-
22
-
-
0028940399
-
Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
-
Johnson, P. G., Lenz, H. J., Leichman, C. G., Danenberg, K. D., Allegra, C. J., Danenberg, P. V., and Leichman, L. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res., 55: 1407-1412, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 1407-1412
-
-
Johnson, P.G.1
Lenz, H.J.2
Leichman, C.G.3
Danenberg, K.D.4
Allegra, C.J.5
Danenberg, P.V.6
Leichman, L.7
-
23
-
-
0028909195
-
Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphocytic leukemia
-
Matherly, L. H., Taub, J. W., Ravindranath, Y., Proefke, S. A., Wong, S. C., Gimotty, P., Buck, S., Wright, J. E., and Rosowsky, A. Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphocytic leukemia. Blood, 85: 500-509, 1995.
-
(1995)
Blood
, vol.85
, pp. 500-509
-
-
Matherly, L.H.1
Taub, J.W.2
Ravindranath, Y.3
Proefke, S.A.4
Wong, S.C.5
Gimotty, P.6
Buck, S.7
Wright, J.E.8
Rosowsky, A.9
-
24
-
-
0024352638
-
Absolute mRNa quantitation using the polymerase chain reaction (PCR). a novel approach by a PCR aided transcript titration assay (PATTY)
-
Becker-Andre, M., and Hahlbrock, K. Absolute mRNA quantitation using the polymerase chain reaction (PCR). A novel approach by a PCR aided transcript titration assay (PATTY). Nucleic Acids Res., 17: 9437-9446, 1989.
-
(1989)
Nucleic Acids Res.
, vol.17
, pp. 9437-9446
-
-
Becker-Andre, M.1
Hahlbrock, K.2
-
25
-
-
0025355882
-
Analysis of cytokine mRNA and DNA: Detection and quantitation by competitive polymerase chain reaction
-
Gilliland, G., Perrin, S., Blanchard, K., and Bunn, H. F. Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction. Proc. Natl. Acad. Sci. USA, 87: 2725-2729, 1990.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 2725-2729
-
-
Gilliland, G.1
Perrin, S.2
Blanchard, K.3
Bunn, H.F.4
-
26
-
-
0030745895
-
Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines
-
Moscow, J. A., Connolly, T., Myers, T. G., Cheng, C. C., Paul, K., and Cowan, K. H. Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines. Int. J. Cancer, 72: 184-190, 1997.
-
(1997)
Int. J. Cancer
, vol.72
, pp. 184-190
-
-
Moscow, J.A.1
Connolly, T.2
Myers, T.G.3
Cheng, C.C.4
Paul, K.5
Cowan, K.H.6
-
27
-
-
0029151314
-
Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine cell line
-
Brigle, K. E., Spinella, M. J., Sierra, E. E., and Goldman, I. D. Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine cell line. J. Biol. Chem., 270: 22974-22979, 1995.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 22974-22979
-
-
Brigle, K.E.1
Spinella, M.J.2
Sierra, E.E.3
Goldman, I.D.4
-
28
-
-
2642697535
-
Mutations in the reduced folate carrier in transport-impaired CCRF-CEM cells
-
Wong, S. C., Proefke, S. A., and Matherly, L. H. Mutations in the reduced folate carrier in transport-impaired CCRF-CEM cells. Proc. Am. Assoc. Cancer Res., 38: 162, 1997.
-
(1997)
Proc. Am. Assoc. Cancer Res.
, vol.38
, pp. 162
-
-
Wong, S.C.1
Proefke, S.A.2
Matherly, L.H.3
-
29
-
-
0030984299
-
Molecular mechanism of antifolate transport-deficiency in a methotrexate resistant MOLT-3 human leukemia cell line
-
Gong, M., Yess, J., Connolly, T., Percy Ivy, S. P., Ohnuma, T., Cowan, K. H., and Moscow, J. A. Molecular mechanism of antifolate transport-deficiency in a methotrexate resistant MOLT-3 human leukemia cell line. Blood, 89: 2494-2499, 1997.
-
(1997)
Blood
, vol.89
, pp. 2494-2499
-
-
Gong, M.1
Yess, J.2
Connolly, T.3
Percy Ivy, S.P.4
Ohnuma, T.5
Cowan, K.H.6
Moscow, J.A.7
-
30
-
-
0026518781
-
Ploidy of lymphoblasts is the strongest predictor of treatment outcome in B-progenitor cell acute lymphoblastic leukemia in childhood: A Pediatric Oncology Group study
-
Trueworthy, R., Shuster, J., Look, T., Crist, W., Borowitz, M., Carroll, A., Frankel, L., Harris, M., Wagner, H., Haggard, M., Mosijczuk, A., Pullen, J., Steuber, P., and Land, V. Ploidy of lymphoblasts is the strongest predictor of treatment outcome in B-progenitor cell acute lymphoblastic leukemia in childhood: a Pediatric Oncology Group study. J. Clin. Oncol., 10: 606-613, 1992.
-
(1992)
J. Clin. Oncol.
, vol.10
, pp. 606-613
-
-
Trueworthy, R.1
Shuster, J.2
Look, T.3
Crist, W.4
Borowitz, M.5
Carroll, A.6
Frankel, L.7
Harris, M.8
Wagner, H.9
Haggard, M.10
Mosijczuk, A.11
Pullen, J.12
Steuber, P.13
Land, V.14
-
31
-
-
0029147794
-
Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate resistant human breast cancer cells
-
Moscow, J. A., Gong, M., He, R., Sgagias, M. K., Dixon, K. H., Anzick, S. L., Meltzer, P. S., and Cowan, K. H. Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate resistant human breast cancer cells. Cancer Res., 55: 3790-3794, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 3790-3794
-
-
Moscow, J.A.1
Gong, M.2
He, R.3
Sgagias, M.K.4
Dixon, K.H.5
Anzick, S.L.6
Meltzer, P.S.7
Cowan, K.H.8
-
32
-
-
0029940952
-
Heterogeneity of hyperdiploid (51-67) childhood acute lymphoblastic leukemia
-
Baltimore
-
Raimondi, S. C., Pui, C. H., Hancock, M. L., Behm, F. G., Filatov, L., and Rivera, G. K. Heterogeneity of hyperdiploid (51-67) childhood acute lymphoblastic leukemia. Leukemia (Baltimore), 10: 213-224, 1996.
-
(1996)
Leukemia
, vol.10
, pp. 213-224
-
-
Raimondi, S.C.1
Pui, C.H.2
Hancock, M.L.3
Behm, F.G.4
Filatov, L.5
Rivera, G.K.6
-
33
-
-
0026537436
-
Trisomy 21 as the sole acquired chromosomal abnormality in children with acute lymphoblastic leukemia
-
Baltimore
-
Raimondi, S. C., Pui, C. H., Head, D., Behm, F., Privitera, E., Roberson, P. K., Rivera, G. K., and Williams, D. L. Trisomy 21 as the sole acquired chromosomal abnormality in children with acute lymphoblastic leukemia. Leukemia (Baltimore), 6: 171-175, 1992.
-
(1992)
Leukemia
, vol.6
, pp. 171-175
-
-
Raimondi, S.C.1
Pui, C.H.2
Head, D.3
Behm, F.4
Privitera, E.5
Roberson, P.K.6
Rivera, G.K.7
Williams, D.L.8
-
34
-
-
0023187384
-
Down syndrome and leukaemia: Unusual clinical aspects and unexpected methotrexate sensitivity
-
Peeters, M., and Poon, A. Down syndrome and leukaemia: unusual clinical aspects and unexpected methotrexate sensitivity. Eur. J. Pediatr., 146: 416-422, 1987.
-
(1987)
Eur. J. Pediatr.
, vol.146
, pp. 416-422
-
-
Peeters, M.1
Poon, A.2
|