Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells

Biochemical Pharmacology

Volumn 61, Issue 6, 2001, Pages 665-675

  Ching Ding, Bee ^a   Witt, Teah L ^a   Hukku, Bharati ^b   Heng, Henry ^a   Zhang, Long ^a   Matherly, Larry H ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

Author keywords

Chromosome 21; Membrane transport; Methotrexate; Reduced folate carrier; Resistance

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; HISTONE DEACETYLASE INHIBITOR; METHOTREXATE; REDUCED FOLATE CARRIER; TRICHOSTATIN A;

5' UNTRANSLATED REGION; ALLELE; ARTICLE; CELL MEMBRANE TRANSPORT; CELL STRAIN K 562; CHROMOSOME 21; CONTROLLED STUDY; DEACETYLATION; DNA SEQUENCE; DRUG TRANSPORT; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENE EXPRESSION; GENE LOCUS; GENE STRUCTURE; GENE TRANSLOCATION; HUMAN; HUMAN CELL; KARYOTYPING; METHYLATION; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE;

5' UNTRANSLATED REGIONS; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HISTONES; HUMANS; HYDROXAMIC ACIDS; IN SITU HYBRIDIZATION, FLUORESCENCE; K562 CELLS; KARYOTYPING; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSLOCATION, GENETIC;

EID: 0035868656     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00535-4     Document Type: Article

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