Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo: A rationale for high-dose methotrexate

Journal of Clinical Investigation

Volumn 97, Issue 1, 1996, Pages 73-80

  Masson, Eric ^b   Relling, Mary V ^b   Synold, Timothy W ^b   Liu, Qing ^b   Schuetz, John D ^b   Sandlund, John T ^b   Pui, Ching Hon ^b   Evans, William E ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b NONE

Author keywords

Leukemia; Methotrexate; Pharmacodynamics; Purine synthesis

Indexed keywords

METHOTREXATE; METHOTREXATE POLYGLUTAMATE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; BLAST CELL; CHILD; CYTOTOXICITY; DOSE RESPONSE; FEMALE; HUMAN; HUMAN CELL; LEUKEMIA; MAJOR CLINICAL STUDY; MALE; PHARMACODYNAMICS; PRESCHOOL CHILD; PRIORITY JOURNAL; PURINE SYNTHESIS; SCHOOL CHILD;

EID: 0030034467     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118409     Document Type: Article

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