A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter within the plasma membrane of tumor cells

Journal of Biological Chemistry

Volumn 273, Issue 5, 1998, Pages 2526-2531

  Roy, Krishnendu ^a   Tolner, Berend ^a   Chiao, Judy H ^a   Sirotnak, F M ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID DERIVATIVE; METHOTREXATE;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; BINDING SITE; CELL TYPE; ELECTROPHORETIC MOBILITY; INTERNALIZATION; MEMBRANE TRANSPORT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN FOLDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; AMINOPTERIN; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL MEMBRANE; DRUG RESISTANCE, NEOPLASM; FOLIC ACID ANTAGONISTS; LEUKEMIA L1210; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PROTEIN CONFORMATION; SARCOMA 180; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR CELLS, CULTURED;

EID: 0032579517     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.5.2526     Document Type: Article

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