The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element: Basis for tissue-specific gene expression

Journal of Biological Chemistry

Volumn 276, Issue 9, 2001, Pages 6350-6358

  Whetstine, Johnathan R ^a   Matherly, Larry H ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MUTAGENESIS; PROTEINS; TISSUE;

ISOFORMS;

GENES;

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; FOLIC ACID; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; VITAMIN D BINDING PROTEIN; CARRIER PROTEIN; CYCLIC AMP; DNA BINDING PROTEIN; MEMBRANE PROTEIN; REDUCED FOLATE CARRIER; SLC19A2 PROTEIN, HUMAN; SP3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ARTICLE; CELL PROLIFERATION; CELL STRAIN HEPG2; DNA PROTEIN COMPLEX; DROSOPHILA; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FAMILY; TATA BOX; TISSUE SPECIFICITY; TRANSACTIVATION; TRANSCRIPTION REGULATION; ANIMAL; ANTIBODY SPECIFICITY; DNA RESPONSIVE ELEMENT; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY;

ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CYCLIC AMP; DNA-BINDING PROTEINS; DROSOPHILA; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0035794180     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008074200     Document Type: Article

References (52)

1. Stokstad, E. L. R. (1990) in Folic Acid Metabolism in Health and Disease (Picciano, M. F., Stokstad, E. L. R., and Gregory, J. F., eds) pp. 1-21, Wiley-Liss, Inc., New York
2. Goldman, I. D., and Matherly, L. H. (1985) Pharmacol. Ther. 28, 77-100
3. Jansen, G. (1999) in Anticancer Development Guide: Antifolate Drugs in Cancer Therapy (Jackman, A. L., ed) pp. 293-321, Humana Press Inc., Totowa, NJ
4. Sirotnak, F. M. (1985) Cancer Res. 45, 3992-4000
5. Sirotnak, F. M., and Tolner, B. (1999) Annu. Rev. Nutr. 19, 91-122
6. Schuetz, J. D., Matherly, L. H., Westin, E. H., and Goldman, I. D. (1988) J. Biol. Chem. 263, 9840-9847
7. Wong, S. C., McQuade, R., Proefke, S. A., and Matherly, L. H. (1997) Biochem. Pharmacol. 53, 199-206
8. Jansen, G., Mauritz, R., Drori, S., Sprecher, H., Kathman, I., Bunni, M., Priest, D. G., Noordhuis, P., Schornagel, J. H., Pinedo, H. M., Peters, G. J., and Assaraf, Y. G. (1998) J. Biol. Chem. 273, 30189-30198
9. Gong, M., Yess, J., Connolly, T., Ivy, S. P., Ohnuma, T., Cowanm K. H., and Moscow, J. A. (1997) Blood 89, 2494-2499
10. Sadlish, H., Murray, R. C., Williams, F. M. R., and Flintoff, W. F. (2000) Biochem. J. 346, 509-516
11. Sirotnak, F. M., Moccio, D. M., Kelleher, L. E., and Goutas, L. J. (1981) Cancer Res. 41, 4442-4452
12. Zhang, L. Taub, J. W., Williamson, M., Wong, S. C., Hukku, B., Pullen, J., Ravindranath, Y., and Matherly, L. H. (1998) Clin. Can. Res. 4, 2169-2177
13. Gorlick, R., Goker, E., Trippett, T., Steinherz, P., Elisseyeff, Y., Mazumdar, M., Flintoff, W. F., and Bertino, J. R. (1997) Blood 89, 1013-1018
14. Guo, W. Healey, J. H., Meyeers, P. A., Ladanyai, M., Huvos, A. G., Bertino, J. R., and Gorlick, R. (1999) Clin. Can. Res. 5, 621-627
15. Refsun, H., Ueland, P., Nygard, O., and Vollset, S. E., (1998) Annu. Rev. Med. 49, 31-62
16. Butterworth, C. E., Jr., and Bendich, A. (1996) Annu. Rev. Nutr. 16, 73-97
17. Albanes, D., and Simone, A. (1994) Nutr. Cancer 22, 101-119
18. Mason, J. B., and Levesque, T. (1996) Oncology 10, 1727-1743
19. Kim, Y. I. J. (1999) Nutr. Biochem. 10, 66-88
20. Dixon, K. H., Lanpher, B. C., Chiu, J., Kelley, K., and Cowan, K. H. (1994) J. Biol. Chem. 269, 17-20
21. Williams, F. M. R., Murray, R. C., Underhill, T. M., and Flintoff, W. F. (1994) J. Biol. Chem. 269, 5810-5816
22. Moscow, J. A., Gong, M., He, R., Sgagias, M. K., Dixon, K. H., Anzick, S. L., Meltzer, P. S., and Cowan, K. H. (1995) Cancer Res. 55, 3790-3794
23. Wong, S. C., Proefke, S. A., Bhushan, A., and Matherly, L. H. (1995) J. Biol. Chem. 270, 17468-17475
24. Williams, F. M. R., and Flintoff, W. F. (1995) J. Biol. Chem. 270, 2987-2992
25. Nguyen, T. T., Dyer, D. L., Dunning, D. D., Rubin, S. A., Grant, K. E., and Said, H. M. (1997) Gastroenterology 112, 783-791
26. Murray, R. C., Williams, F. M. R., and Flintoff, W. F. (1996) J. Biol. Chem. 271, 19174-19179
27. Brigle, K. E., Spinella, M. J., Sierra, E. E., and Goldman, I. D., (1997) Biochim. Biophys. Acta 1353, 191-198
28. Tolner, B., Roy, K., and Sirotnak, F. M. (1997) Gene 189, 1-7
29. Zhang, L., Wong, S. C., and Matherly, L. H. (1998) Biochim. Biophys. Acta 1442, 389-393
30. Tolner, B., Roy, K., and Sirotnak, F. M. (1998) Gene 211, 331-341
31. Williams, F. M. R., and Flintoff, W. F. (1998) Somatic Cell Mol. Genet. 24, 143-156
32. Tolner, B., Singh, A., Esaki, T., Roy, K., and Sirotnak, F. M. (1999) Gene 231, 163-172
33. Zhang, L., Wong, S. C., and Matherly, L. H. (1998) Biochem. J. 332, 773-780
34. Gong, M., Cowan, K. H., Gudas, J., and Moscow, J. A. (1999) Gene 233, 21-31
35. Ausuble, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., Struhl, K. (1998) Current Protocols in Molecular Biology, Vol. 12, pp. 1.1-12.1.9, John Wiley & Sons, Inc., New York
36. Matsudaira, P. (1987) J. Biol. Chem. 262, 10035-10038
37. Philipsen, S., and Suske, G. (1999) Nucleic Acids Res. 27, 2991-3000
38. Suske, G. (1999) Gene 238, 291-300
39. Kennett, S. B., Udvadia, A. J., and Horowitz, J. M. (1997) Nucleic Acids Res. 25, 3110-3117
40. Hagen, G., Müller, S., Beato, M., and Suske, G. (1992) Nucleic Acids Res. 20, 5519-5525
41. Hagen, G., Müller, S., Beato, M., and Suske, G. (1994) EMBO J. 13, 3843-3851
42. Ihn, H., and Trojanowska, M. (1997) Nucleic Acids Res 25, 3712-3717
43. Chen, S. J., Artlett, C. M., Jimenez, S. A., and Varga, J. (1998) Gene 215, 101-110
44. Courey, A. J., and Tjian, R. (1988) Cell 55, 887-898
45. Courey, A. J., Holtzman, D. A., Jackson, S. P., and Tjian, R. (1989) Cell 59, 827-836
46. Pascal, E., and Tjian, R. (1991) Genes Dev. 5, 1646-1656
47. Azizkhan, J. C., Jensen, D. E., Pierce, A. J., and Wade, M. (1993) Crit. Rev. Eukaryotic Gene Expression 3, 229-254
48. Horie, N., and Takeishi, K. (1997) J. Biol. Chem. 272, 18375-18381
49. Li, N., Seetharam, S., and Seetharam, B. (1998) J. Biol. Chem. 273, 16104-16111
50. Shaywitz, A. J., and Greenberg, M. E. (1999)Annu. Rev. Biochem. 68, 821-861
51. Said, H. M., Ma, T. Y., Ortiz, A., Tapia, A., and Valerio, C. K. (1997) Am. J. Physiol. 272, C729-C736
52. Kumar, C. K., Moyer, M. P., Dudeja, P. K., and Said, H. M. (1997) J. Biol. Chem. 272, 6226-6231