In vitro mutations in dihydrofolate reductase that confer resistance to methotrexate: Potential for clinical application

Human Mutation

Volumn 11, Issue 4, 1998, Pages 259-263

  Blakley, Raymond L ^a   Sorrentino, Brian P ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Dihydrofolate reductase mutants; Gene therapy; Methotrexate resistance; Mutagenesis; Myeloprotection; Retroviral transfer

Indexed keywords

DIHYDROFOLATE REDUCTASE; METHOTREXATE; TRIMETREXATE;

DNA POLYMORPHISM; ESCHERICHIA COLI; GENE MUTATION; GENE THERAPY; HEMATOPOIESIS; HUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; REVIEW; SITE DIRECTED MUTAGENESIS;

BONE MARROW TRANSPLANTATION; CELL LINE; DRUG RESISTANCE; ESCHERICHIA COLI; GENE THERAPY; HEMATOPOIESIS; HUMANS; METHOTREXATE; MUTAGENESIS, SITE-DIRECTED; MUTATION; TETRAHYDROFOLATE DEHYDROGENASE; VARIATION (GENETICS);

ESCHERICHIA COLI; MAMMALIA;

EID: 0031976589     PISSN: 10597794     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1004(1998)11:4<259::AID-HUMU1>3.0.CO;2-W     Document Type: Review

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