메뉴 건너뛰기




Volumn 267, Issue 3, 2000, Pages 690-702

Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells

Author keywords

Alternative splicing; Folates; Metabolism; Transporters

Indexed keywords

CARRIER PROTEIN; COMPLEMENTARY DNA; FOLATE CARRIER; FOLIC ACID; FOLINIC ACID; ISOPROTEIN; METHOTREXATE; UNCLASSIFIED DRUG;

EID: 0033967579     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01049.x     Document Type: Article
Times cited : (21)

References (54)
  • 1
    • 0002058353 scopus 로고
    • Historical perspective on key advances in the biochemistry and physiology of folates
    • Picciano, M.F., Stokstad, E.L.R. & Gregory, J.F., eds. Wiley-Liss, New York
    • 1. Stokstad, E.L.R. (1990) Historical perspective on key advances in the biochemistry and physiology of folates. In Folic Acid Metabolism in Health and Disease (Picciano, M.F., Stokstad, E.L.R. & Gregory, J.F., eds), pp. 1-21. Wiley-Liss, New York.
    • (1990) Folic Acid Metabolism in Health and Disease , pp. 1-21
    • Stokstad, E.L.R.1
  • 2
    • 0000921074 scopus 로고    scopus 로고
    • Receptor-and carrier-mediated transport systems for folates and antifolates
    • Jackman, A.L., ed. Humana Press Inc, Totoja, NJ, USA
    • 2. Jansen, G. (1999) Receptor-and carrier-mediated transport systems for folates and antifolates. In Antifolate Drugs in Cancer Therapy (Jackman, A.L., ed.), pp. 293-321. Humana Press Inc, Totoja, NJ, USA.
    • (1999) Antifolate Drugs in Cancer Therapy , pp. 293-321
    • Jansen, G.1
  • 3
    • 0021838288 scopus 로고
    • The cellular pharmacology of methotrexate
    • 3. Goldman, I.D. & Matherly, L.H. (1985) The cellular pharmacology of methotrexate. Pharmacol. Ther. 28, 77-102.
    • (1985) Pharmacol. Ther. , vol.28 , pp. 77-102
    • Goldman, I.D.1    Matherly, L.H.2
  • 4
    • 0022353539 scopus 로고
    • Obligate genetic expression in tumor cells of a fetal membrane property mediating 'folate' transport: Biological significance and implications for improved therapy of human cancer
    • 4. Sirotnak, F.M. (1985) Obligate genetic expression in tumor cells of a fetal membrane property mediating 'folate' transport: biological significance and implications for improved therapy of human cancer. Cancer Res. 45, 3992-4000.
    • (1985) Cancer Res. , vol.45 , pp. 3992-4000
    • Sirotnak, F.M.1
  • 5
    • 0015246387 scopus 로고
    • The characteristics of the membrane transport of amethopterin and the naturally occurring folates
    • 5. Goldman, I.D. (1971) The characteristics of the membrane transport of amethopterin and the naturally occurring folates. Ann. NY Acad. Sci. 186, 400-422.
    • (1971) Ann. NY Acad. Sci. , vol.186 , pp. 400-422
    • Goldman, I.D.1
  • 6
    • 0019851443 scopus 로고
    • Anion exchange mechanism for transport of methotrexate in L1210 cells
    • 6. Henderson, G.B. & Zevely, E.M. (1981) Anion exchange mechanism for transport of methotrexate in L1210 cells. Biochem. Biophys. Res. Commun. 99, 163-169.
    • (1981) Biochem. Biophys. Res. Commun. , vol.99 , pp. 163-169
    • Henderson, G.B.1    Zevely, E.M.2
  • 7
    • 0023471363 scopus 로고
    • Determinants of resistance to antifolates: Biochemical phenotypes, their frequency of occurence and circumvention
    • 7. Sirotnak, F.M. (1987) Determinants of resistance to antifolates: biochemical phenotypes, their frequency of occurence and circumvention. NCI Monogr. 5, 27-35.
    • (1987) NCI Monogr. , vol.5 , pp. 27-35
    • Sirotnak, F.M.1
  • 9
    • 0026446685 scopus 로고
    • Differential stereospecificities and affinities of folate receptor isoforms of folate compounds and antifolates
    • 9. Wang, X., Shen, F., Freisheim, J.H., Gentry, L.F. & Ratnam, M. (1992) Differential stereospecificities and affinities of folate receptor isoforms of folate compounds and antifolates. Biochem. Pharmacol. 44, 1898-1901.
    • (1992) Biochem. Pharmacol. , vol.44 , pp. 1898-1901
    • Wang, X.1    Shen, F.2    Freisheim, J.H.3    Gentry, L.F.4    Ratnam, M.5
  • 10
    • 0026652116 scopus 로고
    • The biological chemistry of folate receptors
    • 10. Antony, A.C. (1992) The biological chemistry of folate receptors. Blood 79, 2807-2820.
    • (1992) Blood , vol.79 , pp. 2807-2820
    • Antony, A.C.1
  • 11
    • 0028008481 scopus 로고
    • Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells
    • 11. Brigle, K.E., Spinella, M.J., Westin, E.H. & Goldman, I.D. (1994) Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells. Biochem. Pharmacol. 47, 337-345.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 337-345
    • Brigle, K.E.1    Spinella, M.J.2    Westin, E.H.3    Goldman, I.D.4
  • 12
    • 0025275523 scopus 로고
    • Characteristics of a novel transport system for folate compounds in wild type and methotrexate-resistant L1210 cells
    • 12. Henderson, G.B. & Strauss, B.P. (1990) Characteristics of a novel transport system for folate compounds in wild type and methotrexate-resistant L1210 cells. Cancer Res. 50, 1709-1714.
    • (1990) Cancer Res. , vol.50 , pp. 1709-1714
    • Henderson, G.B.1    Strauss, B.P.2
  • 13
    • 0032499415 scopus 로고    scopus 로고
    • Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier function
    • 13. Sierra, E.E. & Goldman, I.D. (1998) Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier function. Biochem. Pharmacol. 55, 1505-1512.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 1505-1512
    • Sierra, E.E.1    Goldman, I.D.2
  • 14
    • 0030969765 scopus 로고    scopus 로고
    • A protein-tyrosine kinase-regulated, pH-dependent, carrier-mediated uptake system for folate in human normal colonic epithelial cell line NCM460
    • 14. Kumar, C.K., Moyer, M.P., Dudeja, P.K. & Said, H.M. (1997) A protein-tyrosine kinase-regulated, pH-dependent, carrier-mediated uptake system for folate in human normal colonic epithelial cell line NCM460. J. Biol. Chem. 272, 6226-6231.
    • (1997) J. Biol. Chem. , vol.272 , pp. 6226-6231
    • Kumar, C.K.1    Moyer, M.P.2    Dudeja, P.K.3    Said, H.M.4
  • 15
    • 0032478639 scopus 로고    scopus 로고
    • Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in Chinese hamster ovary cells
    • 15. Assaraf, Y.G., Babani, S. & Goldman, I.D. (1998) Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in Chinese hamster ovary cells. J. Biol. Chem. 273, 8106-8111.
    • (1998) J. Biol. Chem. , vol.273 , pp. 8106-8111
    • Assaraf, Y.G.1    Babani, S.2    Goldman, I.D.3
  • 16
    • 0027982786 scopus 로고
    • A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells
    • 16. Dixon, K.H., Lanpher, B.C., Chiu, J., Kelley, K. & Cowan, K.H. (1994) A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. J. Biol. Chem. 269, 17-20.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17-20
    • Dixon, K.H.1    Lanpher, B.C.2    Chiu, J.3    Kelley, K.4    Cowan, K.H.5
  • 17
    • 0027963626 scopus 로고
    • Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake
    • 17. Williams, F.M.R., Murray, R.C., Underhill, T.M. & Flintoff, W.F. (1994) Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake. J. Biol. Chem. 269, 5810-5816.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5810-5816
    • Williams, F.M.R.1    Murray, R.C.2    Underhill, T.M.3    Flintoff, W.F.4
  • 18
    • 0028887425 scopus 로고
    • Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake
    • 18. Williams, F.M.R. & Flintoff, W.F. (1994) Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. J. Biol. Chem. 270, 2987-2992.
    • (1994) J. Biol. Chem. , vol.270 , pp. 2987-2992
    • Williams, F.M.R.1    Flintoff, W.F.2
  • 20
    • 0029147794 scopus 로고
    • Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells
    • 20. Moscow, J.A., Gong, M.K., He, R., Sgagias, M.K., Dixon, K.H., Anzick, S.L., Meltzer, P.S. & Cowan, K.H. (1995) Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res. 55, 3790-3794.
    • (1995) Cancer Res. , vol.55 , pp. 3790-3794
    • Moscow, J.A.1    Gong, M.K.2    He, R.3    Sgagias, M.K.4    Dixon, K.H.5    Anzick, S.L.6    Meltzer, P.S.7    Cowan, K.H.8
  • 21
    • 0029084385 scopus 로고
    • Isolation of human cDNAs that restore methotrexate sensitivity
    • 21. Wong, S.C., Proefke, S.A., Bhushan, A. & Mathelry, L.H. (1995) Isolation of human cDNAs that restore methotrexate sensitivity. J. Biol. Chem. 270, 17468-17475.
    • (1995) J. Biol. Chem. , vol.270 , pp. 17468-17475
    • Wong, S.C.1    Proefke, S.A.2    Bhushan, A.3    Mathelry, L.H.4
  • 22
    • 0032579517 scopus 로고    scopus 로고
    • A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter within the plasma membrane of tumor cells
    • 22. Roy, K., Tolner, B., Chiao, J.H. & Sirotnak, F.M. (1998) A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter within the plasma membrane of tumor cells. J. Biol. Chem. 273, 2526-2531.
    • (1998) J. Biol. Chem. , vol.273 , pp. 2526-2531
    • Roy, K.1    Tolner, B.2    Chiao, J.H.3    Sirotnak, F.M.4
  • 23
    • 0026474761 scopus 로고
    • Chatacterization of transport-mediated methotrexate resistance in human tumor cells with antibodies to membrane carrier for methotrexate and tetrahydrofolate cofactors
    • 23. Matherly, L.H., Angeles, S.M. & Czajkowski, C.A. (1992) Chatacterization of transport-mediated methotrexate resistance in human tumor cells with antibodies to membrane carrier for methotrexate and tetrahydrofolate cofactors. J. Biol. Chem. 267, 23253-23260.
    • (1992) J. Biol. Chem. , vol.267 , pp. 23253-23260
    • Matherly, L.H.1    Angeles, S.M.2    Czajkowski, C.A.3
  • 25
    • 0021720510 scopus 로고
    • A novel class of genetic variants of L1210 cell up-regulated for folate analogue transport inward
    • 25. Sirotnak, F.M., Moccio, D.M. & Yang, C.-H. (1984) A novel class of genetic variants of L1210 cell up-regulated for folate analogue transport inward. J. Biol. Chem. 259, 13139-13144.
    • (1984) J. Biol. Chem. , vol.259 , pp. 13139-13144
    • Sirotnak, F.M.1    Moccio, D.M.2    Yang, C.-H.3
  • 26
    • 0023733840 scopus 로고
    • Further studies on a novel class of genetic variants of the L1210 cell with increased folate analogue transport inward. Transport properties of a new variant, evidence for increased levels of a specific transport protein, and its partial characterization following affinity labeling
    • 26. Yang, C.-H., Sirotnak, F.M. & Mines, L.S. (1988) Further studies on a novel class of genetic variants of the L1210 cell with increased folate analogue transport inward. Transport properties of a new variant, evidence for increased levels of a specific transport protein, and its partial characterization following affinity labeling. J. Biol. Chem. 263, 9703-9709.
    • (1988) J. Biol. Chem. , vol.263 , pp. 9703-9709
    • Yang, C.-H.1    Sirotnak, F.M.2    Mines, L.S.3
  • 27
    • 0025016121 scopus 로고
    • Methotrexate transport in variant human CCRF-CEM cells with elevated levels of the reduced folate carrier: Selective effect on carrier-mediated transport of physiological concentrations of reduced folates
    • 27. Jansen, G., Westerhof, G.R., Jarmuszewski, M.J.A., Kathmann, I., Rijksen, G. & Schornagel, J.H. (1990) Methotrexate transport in variant human CCRF-CEM cells with elevated levels of the reduced folate carrier: selective effect on carrier-mediated transport of physiological concentrations of reduced folates. J. Biol. Chem. 265, 18272-18277.
    • (1990) J. Biol. Chem. , vol.265 , pp. 18272-18277
    • Jansen, G.1    Westerhof, G.R.2    Jarmuszewski, M.J.A.3    Kathmann, I.4    Rijksen, G.5    Schornagel, J.H.6
  • 28
    • 0008875897 scopus 로고    scopus 로고
    • Reduced folate carrier gene amplification and overexpression of altered transcripts in human leukemia CEM-7A cells
    • 28. Sprecher, H., Jansen, G., Drori, S., Schornagel. J.H., Peters, G.J. & Assaraf, Y.G. (1996) Reduced folate carrier gene amplification and overexpression of altered transcripts in human leukemia CEM-7A cells. Proc. Am. Assoc. Cancer Res. 37, 2601.
    • (1996) Proc. Am. Assoc. Cancer Res. , vol.37 , pp. 2601
    • Sprecher, H.1    Jansen, G.2    Drori, S.3    Schornagel, J.H.4    Peters, G.J.5    Assaraf, Y.G.6
  • 29
    • 0008878786 scopus 로고    scopus 로고
    • Characterization of the human reduced folate carrier (RFC1) gene and an alternatively spliced transcript
    • 29. Shemer, G., Sprecher, H., Drori, S., Pirak, E., Jansen, G. & Assaraf, Y.G. (1998) Characterization of the human reduced folate carrier (RFC1) gene and an alternatively spliced transcript. Proc. Am. Assoc. Cancer Res. 39, 431.
    • (1998) Proc. Am. Assoc. Cancer Res. , vol.39 , pp. 431
    • Shemer, G.1    Sprecher, H.2    Drori, S.3    Pirak, E.4    Jansen, G.5    Assaraf, Y.G.6
  • 30
    • 0020081481 scopus 로고
    • Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their associtaion with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro
    • 30. Fry, D.W., Yalowich, J.C. & Goldman, I.D. (1982) Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their associtaion with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro. J. Biol. Chem. 257, 1890-1896.
    • (1982) J. Biol. Chem. , vol.257 , pp. 1890-1896
    • Fry, D.W.1    Yalowich, J.C.2    Goldman, I.D.3
  • 31
    • 0022570759 scopus 로고
    • Characterization of the individual transport routes that mediate the influx and efflux of methotrexate in CCRF-CEM human lymphoblastic cells
    • 31. Henderson, G.B., Tsuji, J.M. & Kumar, H.P. (1986) Characterization of the individual transport routes that mediate the influx and efflux of methotrexate in CCRF-CEM human lymphoblastic cells. Cancer Res. 46, 1633-1638.
    • (1986) Cancer Res. , vol.46 , pp. 1633-1638
    • Henderson, G.B.1    Tsuji, J.M.2    Kumar, H.P.3
  • 32
  • 33
    • 0029151314 scopus 로고
    • Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line
    • 33. Brigle, K.E., Spinella, M.J., Sierra, E.E. & Goldman, I.D. (1995) Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line. J. Biol. Chem. 270, 22974-22979.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22974-22979
    • Brigle, K.E.1    Spinella, M.J.2    Sierra, E.E.3    Goldman, I.D.4
  • 34
    • 0023277545 scopus 로고
    • A single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • 34. Chomczynski, P. & Sacchi, N. (1987) A single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 36
    • 0029100642 scopus 로고
    • Alteration of mitochondrial gene expression and disruption of respiratory function by the lipophilic antifolate pyrimethamine in mammalian cells
    • 36. Sprecher, H., Barr, H.M., Slotky, J.I., Tzukerman, M., Eytan, G.D. & Assaraf, Y.G. (1995) Alteration of mitochondrial gene expression and disruption of respiratory function by the lipophilic antifolate pyrimethamine in mammalian cells. J. Biol. Chem. 270, 20668-20676.
    • (1995) J. Biol. Chem. , vol.270 , pp. 20668-20676
    • Sprecher, H.1    Barr, H.M.2    Slotky, J.I.3    Tzukerman, M.4    Eytan, G.D.5    Assaraf, Y.G.6
  • 37
    • 0020793569 scopus 로고
    • A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
    • 37. Feinberg, A.P. & Vogelstein, B. (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132, 6-13.
    • (1983) Anal. Biochem. , vol.132 , pp. 6-13
    • Feinberg, A.P.1    Vogelstein, B.2
  • 38
    • 0021759199 scopus 로고
    • Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA
    • 38. Ponte, P., Ng, S.-Y., Engel, J., Gunning, P. & Kedes, L. (1984) Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. Nucleic Acids Res. 12, 1687-1706.
    • (1984) Nucleic Acids Res. , vol.12 , pp. 1687-1706
    • Ponte, P.1    Ng, S.-Y.2    Engel, J.3    Gunning, P.4    Kedes, L.5
  • 39
  • 40
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • 40. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 41
    • 0029089831 scopus 로고
    • Assignment of the human folate transporter gene to chromosome 21q22.3 by somatic cell hybrid analysis and in situ hybridization
    • 41. Yang-Feng, T.L., Ma, Y.-Y., Liang, R., Prasad, P.D., Leibach, F.H. & Ganapathy, V. (1995) Assignment of the human folate transporter gene to chromosome 21q22.3 by somatic cell hybrid analysis and in situ hybridization. Biochem. Biophys. Res. Commun. 210, 874-879.
    • (1995) Biochem. Biophys. Res. Commun. , vol.210 , pp. 874-879
    • Yang-Feng, T.L.1    Ma, Y.-Y.2    Liang, R.3    Prasad, P.D.4    Leibach, F.H.5    Ganapathy, V.6
  • 44
    • 0033523092 scopus 로고    scopus 로고
    • Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion
    • 44. Ferguson, P.L. & Flintoff, W.F. (1999) Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion. J. Biol. Chem. 274, 16269-12278.
    • (1999) J. Biol. Chem. , vol.274 , pp. 16269-112278
    • Ferguson, P.L.1    Flintoff, W.F.2
  • 45
    • 0021735425 scopus 로고
    • Gene amplification in cultured animal cells
    • 45. Schimke, R.T. (1984) Gene amplification in cultured animal cells. Cell 37, 705-713.
    • (1984) Cell , vol.37 , pp. 705-713
    • Schimke, R.T.1
  • 46
    • 0023940788 scopus 로고
    • Gene amplification in cultured cells
    • 46. Schimke, R.T. (1988) Gene amplification in cultured cells. J. Biol. Chem. 263, 5989-5992.
    • (1988) J. Biol. Chem. , vol.263 , pp. 5989-5992
    • Schimke, R.T.1
  • 47
    • 0030279439 scopus 로고    scopus 로고
    • Directing alternative splicing: Cast and scenarios
    • 47. Chabot, B. (1996) Directing alternative splicing: cast and scenarios. Trends Genet. 12, 472-478.
    • (1996) Trends Genet. , vol.12 , pp. 472-478
    • Chabot, B.1
  • 48
    • 0030839959 scopus 로고    scopus 로고
    • Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells
    • 48. Assaraf, Y.G. & Goldman, I.D. (1997) Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells. J. Biol. Chem. 272, 17460-17466.
    • (1997) J. Biol. Chem. , vol.272 , pp. 17460-17466
    • Assaraf, Y.G.1    Goldman, I.D.2
  • 49
    • 0030841332 scopus 로고    scopus 로고
    • Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
    • 49. Kool, M., de Hoos, M., Scheffer, G.L., Scheper, R.J., van Eijk, M.J., Juin, J.A., Baas, F. & Borst, P. (1997) Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 57, 3527-3547.
    • (1997) Cancer Res. , vol.57 , pp. 3527-3547
    • Kool, M.1    De Hoos, M.2    Scheffer, G.L.3    Scheper, R.J.4    Van Eijk, M.J.5    Juin, J.A.6    Baas, F.7    Borst, P.8
  • 50
    • 0030753176 scopus 로고    scopus 로고
    • Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats
    • 50. Masuda, M., Fizuka, Y., Yamazaki, M., Nishigaki, R., Kato, Y., Ni'inuma, K., Suzuki, H. & Sugiyama, Y. (1997) Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats. Cancer Res. 57, 3506-3510.
    • (1997) Cancer Res. , vol.57 , pp. 3506-3510
    • Masuda, M.1    Fizuka, Y.2    Yamazaki, M.3    Nishigaki, R.4    Kato, Y.5    Ni'inuma, K.6    Suzuki, H.7    Sugiyama, Y.8
  • 52
    • 0032865435 scopus 로고    scopus 로고
    • 1 is a potent inhibitor of membrane transport of folates mediated by the reduced folate carrier and ATP-driven exporters
    • 1 is a potent inhibitor of membrane transport of folates mediated by the reduced folate carrier and ATP-driven exporters. Biochem. Pharmacol. 58, 1321-1327.
    • (1999) Biochem. Pharmacol. , vol.58 , pp. 1321-1327
    • Assaraf, Y.G.1    Sierra, E.E.2    Babani, S.3    Goldman, I.D.4
  • 53
    • 0028203332 scopus 로고
    • Detection of oligomeric and monomeric forms of P-glycoprotein in multidrug resistant cells
    • 53. Poruchynsky, M.S. & Ling, V. (1994) Detection of oligomeric and monomeric forms of P-glycoprotein in multidrug resistant cells. Biochemistry 33, 4163-4174.
    • (1994) Biochemistry , vol.33 , pp. 4163-4174
    • Poruchynsky, M.S.1    Ling, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.