Functional role of arginine 373 in substrate translocation by the reduced folate carrier

Journal of Biological Chemistry

Volumn 277, Issue 44, 2002, Pages 42105-42112

  Sadlish, Heather ^a   Williams, Frederick M R ^a   Flintoff, Wayne F ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DATA REDUCTION; PROTEINS; SUBSTRATES;

TRANSLOCATION;

BIOCHEMISTRY;

ALANINE; ARGININE; ASPARAGINE; CYSTEINE; FOLIC ACID; GLUTAMIC ACID; GLUTAMINE; HISTIDINE; HYBRID PROTEIN; LYSINE; METHANETHIOSULFONATE; MUTANT PROTEIN; REAGENT; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; KINETICS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT;

ANIMALS; ARGININE; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CHO CELLS; CRICETINAE; MEMBRANE TRANSPORT PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0036828910     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206459200     Document Type: Article

References (33)

1. Lucock, M. (2000) Mol. Genet. Metab. 71, 121-138
2. Gorlick, R., Goker, E., Trippett, T., Steinherz, P., Elisseyeff, Y., Mazumdar, M., Flintoff, W. F., and Bertino, J. R. (1997) Blood 89, 1013-1018
3. Guo, W., Healey, J. H., Meyers, P. A., Ladanyi, M., Huvos, A. G., Bertino, J. R., and Gorlick, R. (1999) Clin. Cancer Res. 5, 621-627
4. Ma, D., Huang, H., and Moscow, J. A. (2000) Biochem. Biophys. Res. Commun. 279, 891-897
5. Ferguson, P. L., and Flintoff, W. F. (1999) J. Biol. Chem. 274, 16269-16278
6. Sadlish, H., Williams, F. F., and Flintoff, W. F. (2002) Biochem. J. 364, 777-786
7. Sharina, I. G., Zhao, R., Wang, Y., Babani, S., and Goldman, I. D. (2002) Biochem. Pharmacol. 63, 1717-1724
8. Roy, K., Tolner, B., Chiao, J. H., and Sirotnak, F. M. (1998) J. Biol. Chem. 273, 2526-2531
9. Zhao, R., Assaraf, Y. G., and Goldman, I. D. (1998) J. Biol. Chem. 273, 7873-7879
10. Tse, A., Brigle, K., Taylor, S. M., and Moran, R. G. (1998) J. Biol. Chem. 273, 25953-25960
11. Jansen, G., Mauritz, R., Drori, S., Sprecher, H., Kathmann, I., Bunni, M., Priest, D. G., Noordhuis, P., Schornagel, J. H., Pinedo, H. M., Peters, G. J., and Assaraf, Y. G. (1998) J. Biol. Chem. 273, 30189-30198
12. Zhao, R., Gao, F., and Goldman, I. D. (1999) Biochem. Pharmacol. 58, 1615-1624
13. Zhao, R., Gao, F., Babani, S., and Goldman, I. D. (2000) Clin. Cancer Res. 6, 3304-3311
14. Zhao, R., Gao, F., Wang, P. J., and Goldman, I. D. (2000) Mol. Pharmacol. 57, 317-323
15. Sharina, I. G., Zhao, R., Wang, Y., Babani, S., and Goldman, I. D. (2001) Mol. Pharmacol. 59, 1022-1028
16. Brigle, K. E., Spinella, M. J., Sierra, E. E., and Goldman, I. D. (1995) J. Biol. Chem. 270, 22974-22979
17. Zhao, R., Assaraf, Y. G., and Goldman, I. D. (1998) J. Biol. Chem. 273, 19065-19071
18. Wong, S. C., Zhang, L., Witt, T. L., Proefke, S. A., Bhushan, A., and Matherly, L. H. (1999) J. Biol. Chem. 274, 10388-10394
19. Sadlish, H., Murray, R. C., Williams, F. M., and Flintoff, W. F. (2000) Biochem. J. 346, 509-518
20. Liu, X. Y., and Matherly, L. H. (2001) Biochem. J. 358, 511-516
21. Flintoff, W. F., and Nagainis, C. R. (1983) Arch. Biochem. Biophys. 223, 433-440
22. Flintoff, W. F., Davidson, S. V., and Siminovitch, L. (1976) Somatic Cell Genet. 2, 245-261
23. Flintoff, W. F., Spindler, S. M., and Siminovitch, L. (1976) In Vitro 12, 749-757
24. Williams, F. M., Murray, R. C., Underhill, T. M., and Flintoff, W. F. (1994) J. Biol. Chem. 269, 5810-5816
25. Murray, R. C. (1997) The Reduced Folate Carrier Gene in Chinese Hamster Ovary Cells: Gene Characterization and Mutant Analysis. Ph.D. thesis, University of Western Ontario, London, Ontario, Canada
26. Gross-Bellard, M., Oudet, P., and Chambon, P. (1973) Eur. J. Biochem. 36, 32-38
27. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., pp. 9.38-9.46, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
28. Underhill, T. M., and Flintoff, W. F. (1989) Somatic Cell Mol. Genet. 15, 49-59
29. Chan, F. P., Williams, F. M., Rogers, K. A., and Flintoff, W. F. (1995) Cytogenet. Cell Genet. 71, 148-150
30. Sun, J., and Kaback, H. R. (1997) Biochemistry 36, 11959-11965
31. Kim, Y. M., Ye, L., and Maloney, P. C. (2001) J. Biol. Chem. 276, 36681-36686
32. Ward, S. D., Hamdan, F. F., Bloodworth, L. M., and Wess, J. (2002) J. Biol. Chem. 277, 2247-2257
33. Frillingos, S., Sahin-Toth, M., Wu, J., and Kaback, H. R. (1998) FASEB J. 12, 1281-1299