A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function

Journal of Biological Chemistry

Volumn 273, Issue 30, 1998, Pages 19065-19071

  Zhao, Rongbao ^a   Assaraf, Yehuda G ^a,b   Goldman, I David ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANION; CARRIER PROTEIN; COMPLEMENTARY DNA; FOLIC ACID; FOLIC ACID ANTAGONIST; FOLINIC ACID; GLUTAMIC ACID; LYSINE; MEMBRANE PROTEIN; METHOTREXATE; RNA;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG TRANSPORT; MOUSE; MUTATION; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANIMALS; ANIONS; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; DRUG RESISTANCE, NEOPLASM; FOLIC ACID; GLUTAMIC ACID; KINETICS; LEUKEMIA L1210; LYSINE; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; MICE; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0032563287     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.30.19065     Document Type: Article

References (37)

1. Daly, L. E., Kirke, P. N., Molloy, A., Weir, D. G., and Scott, J. M. (1995) J. Am. Med. Assoc. 274, 1698-1702
2. Butterworth, C. E. (1993) in Health and Disease (Bendich, A., and Butterworth, C. E., eds) pp. 165-185, Marcel Dekker, Inc., New York
3. Boushey, C. J., Beresford, S. A., Omenn, G. S., and Motulsky, A. G. (1995) J. Am. Med. Assoc. 274, 1049-1057
4. Rimm, E. B., Willett, W. C., Hu, F. B., Sampson, L., Colditz, G. A., Mason, J. E., Hennekens, C., and Stampfer, M. J. (1998) J. Am. Med. Assoc. 279, 359-364
5. Henderson, G. B. (1990) Annu. Rev. Nutr. 10, 319-335
6. Sirotnak, F. M. (1986) in Membrane Transport of Antineoplastic Agents (Goldman, I. D., ed) pp. 241-281, Pergamon Press Ltd., Oxford
7. Goldman, I. D., and Matherly, L. H. (1986) in Membrane Transport of Antineoplastic Agents (Goldman, I. D., ed) pp. 283-308, Pergamon Press Ltd., Oxfort
8. Matherly, L. H., Taub, J. W., Ravindranath, Y., Proefke, S. A., Wong, S. C., Gimotty, P., Buck, S., Wright, J. E., and Rosowsky, A. (1995) Blood 85, 500-509
9. Gorlick, R., Goker, E., Trippett, T., Steinherz, P., Elisseyeff, Y., Mazumdar, M., Flintoff, W. F., and Bertino, J. R. (1997) Blood 89, 1013-1018
10. Dixon, K. H., Lanpher, B. C., Chiu, J., Kelley, K., and Cowan, K. H. (1994) J. Biol. Chem. 269, 17-20
11. Williams, F. M. R., Murray, R. C., Underbill, T. M., and Flintoff, W. F. (1994) J. Biol. Chem. 269, 5810-5816
12. Williams, F. M. R., and Flintoff, W. F. (1995) J. Biol. Chem. 270, 2987-2992
13. Prasad, P. D., Ramamoorthy, S., Leibach, F. H., and Ganapathy, V. (1995) Biochem. Biophys. Res. Commun. 206, 681-687
14. Moscow, J. A., Gong, M. K., He, R., Sgagias, M. K., Dixon, K. H., Anzick, S. L., Meltzer, P. S., and Cowan, K. H. (1995) Cancer Res. 55, 3790-3794
15. Wong, S. C., Proefke, S. A., Bhushan, A., and Matherly, L. H. (1995) J. Biol. Chem. 270, 17468-17475
16. Zhao, R., Assaraf, Y. G., and Goldman, I. D. (1998) J. Biol. Chem. 273, 7873-7879
17. Tse, A., Brigle, K. E., and Moran, R. G. (1997) Proc. Am. Assoc. Cancer Res. 38, 162
18. Fry, D. W., Yalowich, J. C., and Goldman, I. D. (1982) J. Biol. Chem. 257, 1890-1896
19. Zhao, R., Seither, R., Brigle, K. E., Sharina, I. G., Wang, P. J., and Goldman, I. D. (1997) J. Biol. Chem. 272, 21207-21212
20. Lee, G. S., Blonsky, K. S., Van On, D. L., Savage, E. A., Morgan, A. R., and von Borstel, R. C. (1992) J. Mol. Biol. 223, 617-626
21. Schuetz, J. D., Matherly, L. H., Westin, E. H., and Goldman, I. D. (1988) J. Biol. Chem. 263, 9840-9847
22. Brigle, K. E., Spinella, M. J., Sierra, E. E., and Goldman, I. D. (1995) J. Biol. Chem. 270, 22974-22979
23. Yang, C.-H., Dembo, M., and Sirotnak, F. M. (1983) J. Membr. Biol. 75, 11-20
24. Goldman, I. D. (1971) Ann. N. Y. Acad. Sci. 186, 400-422
25. Yang, C.-H., Sirotnak, F. M., and Dembo, M. (1984) J. Membr. Biol. 79, 285-292
26. Henderson, G. B., and Zevely, E. M. (1983) Arch. Biochem. Biophys. 221, 438-446
27. Henderson, G. B., and Zevely, E. M. (1980) Arch. Biochem. Biophys. 200, 149-155
28. Henderson, G. B., and Zevely, E. M. (1983) Biochem. Int. 6, 507-515
29. Goldman, I. D., Lichtenstein, N. S., and Oliverio, V. T. (1968) J. Biol. Chem. 243, 5007-5017
30. Sirotnak, F. M. (1987) NCI Monogr. 5, 27-35
31. Assaraf, Y. G., Babani, S., and Goldman, I. D. (1998) J. Biol. Chem. 273, 8106-8111
32. Henderson, G. B., and Strauss, B. P. (1990) Cancer Res. 50, 1709-1714
33. Spinella, M. J., Brigle, K. E., Sierra, E. E., and Goldman, I. D. (1995) J. Biol. Chem. 270, 7842-7849
34. Sirotnak, F. M., Goutas, L. J., and Mines, L. S. (1985) Cancer Res. 45, 4732-4734
35. Roy, K., Tolner, B., Chiao, J. H., and Sirotnak, F. M. (1998) J. Biol. Chem. 273, 2526-2531
36. Goldman, I. D. (1971) Biochim. Biophys. Acta 233, 624-634
37. Muller-Berger, S., Karbach, D., Kang, D., Aranibar, N., Wood, P. G., Ruterjans, H., and Passow, H. (1995) Biochemistry 34, 9325-9332