A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate

Journal of Biological Chemistry

Volumn 273, Issue 14, 1998, Pages 7873-7879

  Zhao, Rongbao ^a   Assaraf, Yehuda G ^a,b   Goldman, I David ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; ASPARAGINE; FOLIC ACID; FOLINIC ACID; MESSENGER RNA; METHOTREXATE; SERINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; DRUG RESISTANCE; DRUG TRANSPORT; GENETIC TRANSFECTION; LEUKEMIA CELL; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CARRIER PROTEINS; CELL DIVISION; DRUG RESISTANCE, NEOPLASM; FOLIC ACID ANTAGONISTS; LEUCOVORIN; LEUKEMIA, EXPERIMENTAL; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; MICE; MUTATION; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE;

EID: 0032478826     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.14.7873     Document Type: Article

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