Folate homeostasis and antiproliferative activity of folates and antifolates

Nutrition

Volumn 17, Issue 9, 2001, Pages 737-738

  Peters, Godefridus J ^a   Jansen, Gerrit ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; FOLIC ACID; FOLINIC ACID; HOMOCYSTEINE; METHOTREXATE; THYMIDINE PHOSPHATE;

CANCER PREVENTION; CELL PROLIFERATION; CELL STRAIN CACO 2; CHEMOPROPHYLAXIS; COLON CANCER; EDITORIAL; FOLIC ACID DEFICIENCY; HUMAN; HUMAN CELL; LEUKEMIA; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ANIMALS; CACO-2 CELLS; CELL DIVISION; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; FOLIC ACID; FOLIC ACID ANTAGONISTS; FOLIC ACID DEFICIENCY; HOMEOSTASIS; HOMOCYSTEINE; HUMANS; KINETICS; MICE; RISK FACTORS;

EID: 0034872907     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(01)00618-9     Document Type: Editorial

References (12)

1. Pharmacokinetics of leucovorin metabolites in human plasma as a function of dose administered orally and intravenously
2. Disposition of folic acid and its metabolites; a comparison with leucovorin
3. Folate and chemoprevention of colorectal cancer. Is 5-methyl-tetrahydrofolate an active antiproliferative agent in folate-treated colon cancer cells?
4. Clinical Pharmacokinetics of anti-metabolites
5. Receptor- and carrier-mediated transport systems for folates and antifolates. Exploitation for folate-based chemotherapy and immunotherapy
6. A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance
7. In vitro activity of normal antifolates against human squamous cell carcinoma cell lines of the head and neck with inherent resistance to methotrexate
8. Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions
9. Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates
10. Disposition of leucovorin and its metabolites in dietary folic acid-depleted mice-comparison between tumor, liver and plasma
11. Augmentation of therapeutic activity of Lometrexol [(6-R)5,10-dideazahydrofolate] by oral folic acid
12. Modulation of both endogenous folates and thymidine enhance the therapeutic effects of thymidylate synthase inhibitors