A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia

Molecular Genetics and Metabolism

Volumn 70, Issue 4, 2000, Pages 310-315

  Chango, Abalo ^a   Emery Fillon, Nathalie ^a   De Courcy, Géneviève Potier ^b   Lambert, Daniel ^a   Pfister, Michèle ^a   Rosenblatt, David S ^c   Nicolas, Jean Pierre ^a  

^a INSERM   (France)

^b Bioinformatique et Chimie Moléculaire   (France)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Folate status; Homocysteine; Methylenetetrahydrofolate reductase; Polymorphism; Reduced folate carrier

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ADENINE; CELL DNA; COMPLEMENTARY DNA; FOLIC ACID; GUANINE; HOMOCYSTEINE; REDUCED FOLATE CARRIER;

AMINO ACID BLOOD LEVEL; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; EXON; FOLATE METABOLISM; GENOTYPE; HOMOZYGOTE; HUMAN; HUMAN CELL; HYPERHOMOCYSTEINEMIA; NONHUMAN; NORMAL HUMAN; NUCLEIC ACID BASE SUBSTITUTION; PATHOGENESIS; PRIORITY JOURNAL; SKIN FIBROBLAST;

EID: 0033805360     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.2000.3034     Document Type: Article

References (29)

1. Inherited disorders of folate transport and metabolism
2. The implications of genetic diversity for the nutrient requirements: The case of folate
3. Folate and carcinogenesis: Evidence, mechanism, and implication
4. Effects of folate deficiency on embryonic development
5. Neural tube and craniofacial defects with special emphasis on folate pathway genes
6. Intestinal absorption of folate
7. Human intestinal folate transport: Cloning, expression, and distribution of complementary RNA
8. The biological chemistry of folate receptors
9. Multiple folate transport systems in L1210 cells
10. Characterization of the individual transport routes that mediate the influx and efflux of methotrexate in CCRF-CEM human lymphoblastic cells
11. Isolation of a gene encoding a human reduced folate carrier (RFC-1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells
12. Obligate genetic expression in tumor cells of a fetal membrane property mediating 'folate' transport: Biological significance and implications for improved therapy of human cancer
13. The mechanism of 5-methyltetrahydrofolate transport by human erythrocytes
14. Genetic effects on variation in red-blood-cell folate in adults: Implications for the familial aggregation of neural tube defects
15. A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells
16. Whole-blood folate values in subjects with different methylenetetrahydrofolate reductase genotypes: Differences between the radioassay and microbiological assays
17. Plasma homocysteine levels related to interactions between folate status and methylenetetrahydrofolate reductase: A study in 52 healthy subjects
18. Role of N-glycosylation in the structure and function of the methotrexate membrane transporter from CCRF-CEM human lymphoblastic leukemia cells
19. Assignment of the human folate transporter gene to chromosome 21q22.3 by somatic cell hybrid analysis and in situ hybridization
20. A primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers in a general population: The Su. VI. MAX study-design, methods, and participant characteristics
21. Rapid high-performance liquide chromatographique assay for total homocysteine levels in human serum
22. Teneur en acide folique des aliments. 2-Optimisation du dosage microbiologique des folates dans les aliments
23. Method of assay or red cell folate activity and the value of the assay as a test for folate deficiency
24. Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective chinese hamster ovary cells
25. A candidate genetic risk factor for vascular disease: A common mutation MTHFR
26. Molecular cloning of the human placental folate transporter
27. Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake
28. Folate receptors
29. Role of folate receptor and reduced folate carrier in the transport of 5-methyltetrahydrofolic acid in human ovarian carcinoma cells