The murine-reduced folate carrier gene can act as a selectable marker and a suicide gene in hematopoietic cells in vivo

Human Gene Therapy

Volumn 13, Issue 14, 2002, Pages 1777-1782

  Liu, Shuqian ^a   Song, Lifu ^a   Bevins, Robert ^a   Birhiray, Ogheneruemu ^a   Moscow, Jeffrey A ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; FOLIC ACID ANTAGONIST; METHOTREXATE; TRIMETREXATE; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL COUNT; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EXPOSURE; HEMATOPOIETIC CELL; IN VIVO STUDY; IRRADIATION; MARKER GENE; MOUSE; NONHUMAN; RETROVIRUS; SUICIDE GENE; TRANSGENE; VIRUS REPLICATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BONE MARROW TRANSPLANTATION; BREAST NEOPLASMS; CARRIER PROTEINS; CELL DEATH; COLONY-FORMING UNITS ASSAY; DEFECTIVE VIRUSES; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE THERAPY; GENETIC VECTORS; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELLS; HUMANS; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; RADIATION CHIMERA; RETROVIRIDAE; SELECTION (GENETICS); TRANSDUCTION, GENETIC; TRIMETREXATE; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 0036400916     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303402760293600     Document Type: Article

References (17)

1. Allay, J.A., Persons, D.A., Galipeau, J., Riperdy, J.M., Ashmun, R.A., Blakley, R.L., and Sorrentino, B.P. (1998). In vivo selection of retrovirally transduced hematopoietic stem cells. Nat. Med. 4, 1136-1143.
2. Bonini, C., Ferrari, G., Verzeletti, S., Servida, P., Zappone, E., Ruggieri, L., Ponzoni, M., Rossini, S., Mavilio, F., Traversari, C., and Bordignon, C. (1997). HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 276, 1719-1724.
3. James, R., Warlick, C., Diers, M., Gunther, R., and Mcivor, R. (2000). Mild preconditioning and low-level engraftment confer methotrexate resistance in mice transplanted with marrow expressing drug-resistant dihydrofolate reductase activity. Blood 96, 1334-1341.
4. Li, M.-X., Banerjee, D., Zhao, S.-C., Schweitzer, B.I., Mineishi, S., Gilboa, E., and Bertino, J.R. (1994). Development of a retroviral construct containing a human mutated dihydrofolate reductase cDNA for hematopoietic stem cell transduction. Blood 83, 3403-3408.
5. May, C., Gunther, R., and Mcivor, R.S. (1995). Protection of mice from lethal doses of methotrexate by transplantation with transgenic marrow expressing drug-resistant dihydrofolate reductase activity. Blood 86, 2439-2448.
6. Moscow, J.A., Connolly, T., Myers, T., Paull, K., Cheng, C.C., and Cowan, K.H. (1997). Reduced folate carrier gene expression in transfected and non-selected cell lines. Int. J. Cancer 72, 184-190.
7. Moscow, J.A., Gong, M., He, R., Sgagias, M.K., Dixon, K.H., Anzick, S.L., Meltzer, P.S., and Cowan, K.H. (1995a). Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res. 55, 3790-3794.
8. Moscow, J.A., Johnston, P.G., Cole, D., Poplack, D.G., and Cowan, K.H. (1995b). Characterization of cross-resistance to methotrexate in a human breast cancer cell line selected for resistance to melphalan. Biochem. Pharmacol. 49, 1069-1078.
9. Ohnuma, T., Lo, R.J., Scanlon, K.J., Kamen, B.A., Ohnoshi, T., Wolman, S.R., and Holland, J.F. (1985). Evolution of methotrexate resistance of human acute lymphoblastic leukemia cells in vitro. Cancer Res. 45, 1815-1822.
10. Pinard, M.-F., Jolivet, J., Ratnam, M., Kathmann, I., Molthoff, C., Westerhof, R., Schornagel, J.H., and Jansen, G. (1996). Functional aspects of membrane folate receptors in human breast cancer cells with transport-related resistance to methotrexate. Cancer Chemother. Pharmacol. 38, 281-288.
11. Prasad, P.D., Ramamoorthy, S., Leibach, F.H., and Ganapathy, V. (1995). Molecular cloning of the human placental folate transporter. Biochem. Biophys. Res. Commun. 206, 681-687.
12. Rosowsky, A., Lazarus, H., Yuan, G.C., Beltz, W.R., Mangini, L., Abelson, H.T., Modest, E.J., and Frei, E.D. (1980). Effects of methotrexate esters and other lipophilic antifolates on methotrexate-resistant human leukemic lymphoblasts. Biochem. Pharmacol. 29, 648-652.
13. Tse, A., Brigle, K. Taylor, s.M., and Moran, R.G. (1998). Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate. J. Biol. Chem. 273, 25953-25960.
14. Verzeletti, S., Bonini, C., Marktel, S., Nobili, N., Cicerci, F., Traversari, C., and Bordignon, C. (1998). Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: Clinical follow-up and improved new vectors. Hum. Gene Ther. 9, 2243-2251.
15. Williams, F.M., and Flintoff, W.F. (1995). Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. J. Biol. Chem. 270, 2987-2992.
16. Wong, S.C., Proefke, S.A., and Bhushan, A. (1995). Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-deficient Chinese hamster ovary cells. J. Biol. Chem. 270, 17468-17475.
17. Zhao, S.-C., Banerjee, D., Mineishi, S., and Bertino, J.R. (1997). Post-transplant methotrexate administration leads to improved curability of mice bearing a mammary tumor transplanted with marrow transduced with a mutant dihydrofolate reductase cDNA. Hum. Gene Ther. 8, 903-909.