메뉴 건너뛰기




Volumn 2, Issue 4, 2002, Pages 289-300

MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE B; PROTEIN TYROSINE KINASE; VASCULOTROPIN RECEPTOR 1; CD11B ANTIGEN; MESSENGER RNA; PRIMER DNA;

EID: 0036782035     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1535-6108(02)00153-8     Document Type: Article
Times cited : (787)

References (58)
  • 1
    • 0029867554 scopus 로고    scopus 로고
    • Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
    • Barleon, B., Sozzani, S., Zhou, D., Weich, H.A., Mantovani, A., and Marme, D. (1996). Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87, 3336-3343.
    • (1996) Blood , vol.87 , pp. 3336-3343
    • Barleon, B.1    Sozzani, S.2    Zhou, D.3    Weich, H.A.4    Mantovani, A.5    Marme, D.6
  • 2
    • 0030932842 scopus 로고    scopus 로고
    • Mapping of the sites for ligand binding and receptor dimerization at the extracellular domain of the vascular endothelial growth factor receptor FLT-1
    • Barleon, B., Totzke, F., Herzog, C., Blanke, S., Kremmer, E., Siemeister, G., Marme, D., and Martiny-Baron, G. (1997). Mapping of the sites for ligand binding and receptor dimerization at the extracellular domain of the vascular endothelial growth factor receptor FLT-1. J. Biol. Chem. 272, 10382-10388.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10382-10388
    • Barleon, B.1    Totzke, F.2    Herzog, C.3    Blanke, S.4    Kremmer, E.5    Siemeister, G.6    Marme, D.7    Martiny-Baron, G.8
  • 4
    • 0033873628 scopus 로고    scopus 로고
    • Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin
    • Betsuyaku, T., Fukuda, Y., Parks, W.C., Shipley, J.M., and Senior, R.M. (2000). Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin. Am. J. Pathol. 157, 525-535.
    • (2000) Am. J. Pathol. , vol.157 , pp. 525-535
    • Betsuyaku, T.1    Fukuda, Y.2    Parks, W.C.3    Shipley, J.M.4    Senior, R.M.5
  • 6
    • 0029929716 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis
    • Clauss, M., Weich, H., Breier, G., Knies, U., Rockl, W., Waltenberger, J., and Risau, W. (1996). The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J. Biol. Chem. 271, 17629-17634.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17629-17634
    • Clauss, M.1    Weich, H.2    Breier, G.3    Knies, U.4    Rockl, W.5    Waltenberger, J.6    Risau, W.7
  • 8
    • 0034721666 scopus 로고    scopus 로고
    • MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
    • Coussens, L.M., Tinkle, C.L., Hanahan, D., and Werb, Z. (2000). MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103, 481-490.
    • (2000) Cell , vol.103 , pp. 481-490
    • Coussens, L.M.1    Tinkle, C.L.2    Hanahan, D.3    Werb, Z.4
  • 10
    • 0032818583 scopus 로고    scopus 로고
    • Expression and localization of placenta growth factor and PIGF receptors in human meningiomas
    • Donnini, S., Machein, M.R., Plate, K.H., and Weich, H.A. (1999). Expression and localization of placenta growth factor and PIGF receptors in human meningiomas. J. Pathol. 189, 66-71.
    • (1999) J. Pathol. , vol.189 , pp. 66-71
    • Donnini, S.1    Machein, M.R.2    Plate, K.H.3    Weich, H.A.4
  • 11
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad, M., and Werb, Z. (2002). New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer 2, 161-174.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 12
    • 0027181497 scopus 로고
    • Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development
    • Eichmann, A., Marcelle, C., Breant, C., and Le Douarin, N.M. (1993). Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development. Mech. Dev. 42, 33-48.
    • (1993) Mech. Dev. , vol.42 , pp. 33-48
    • Eichmann, A.1    Marcelle, C.2    Breant, C.3    Le Douarin, N.M.4
  • 13
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • Ferrara, N., and Davis-Smyth, T. (1997). The biology of vascular endothelial growth factor. Endocr. Rev. 18, 4-25.
    • (1997) Endocr. Rev. , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 14
    • 0026846928 scopus 로고
    • The role of angiogenesis in tumor growth
    • Folkman, J. (1992). The role of angiogenesis in tumor growth. Semin. Cancer Biol. 3, 65-71.
    • (1992) Semin. Cancer Biol. , vol.3 , pp. 65-71
    • Folkman, J.1
  • 16
    • 0032846119 scopus 로고    scopus 로고
    • Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: Involvement of transforming growth factor beta1
    • Gohongi, T., Fukumura, D., Boucher, Y., Yun, C.O., Soff, G.A., Compton, C., Todoroki, T., and Jain, R.K. (1999). Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1. Nat. Med. 5, 1203-1208.
    • (1999) Nat. Med. , vol.5 , pp. 1203-1208
    • Gohongi, T.1    Fukumura, D.2    Boucher, Y.3    Yun, C.O.4    Soff, G.A.5    Compton, C.6    Todoroki, T.7    Jain, R.K.8
  • 17
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan, D., and Folkman, J. (1996). Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 18
    • 0036344496 scopus 로고    scopus 로고
    • Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
    • Hattori, K., Heissig, B., Wu, Y., Dias, S., Tejada, R., Ferris, B., Hicklin, D.J., Zhu, Z., Bohlen, P., Witte, L., et al. (2002). Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat. Med. 8, 841-849.
    • (2002) Nat. Med. , vol.8 , pp. 841-849
    • Hattori, K.1    Heissig, B.2    Wu, Y.3    Dias, S.4    Tejada, R.5    Ferris, B.6    Hicklin, D.J.7    Zhu, Z.8    Bohlen, P.9    Witte, L.10
  • 19
    • 0030091641 scopus 로고    scopus 로고
    • Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas
    • Hatva, E., Bohling, T., Jaaskelainen, J., Persico, M.G., Haltia, M., and Alitalo, K. (1996). Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas. Am. J. Pathol. 148, 763-775.
    • (1996) Am. J. Pathol. , vol.148 , pp. 763-775
    • Hatva, E.1    Bohling, T.2    Jaaskelainen, J.3    Persico, M.G.4    Haltia, M.5    Alitalo, K.6
  • 20
    • 0032482978 scopus 로고    scopus 로고
    • Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
    • Hiratsuka, S., Minowa, O., Kuno, J., Noda, T., and Shibuya, M. (1998). Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. USA 95, 9349-9354.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9349-9354
    • Hiratsuka, S.1    Minowa, O.2    Kuno, J.3    Noda, T.4    Shibuya, M.5
  • 21
    • 0035114105 scopus 로고    scopus 로고
    • Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis
    • Hiratsuka, S., Maru, Y., Okada, A., Seiki, M., Noda, T., and Shibuya, M. (2001). Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. Cancer Res. 61, 1207-1213.
    • (2001) Cancer Res. , vol.61 , pp. 1207-1213
    • Hiratsuka, S.1    Maru, Y.2    Okada, A.3    Seiki, M.4    Noda, T.5    Shibuya, M.6
  • 22
    • 0032031861 scopus 로고    scopus 로고
    • Reduced angiogenesis and tumor progression in gelatinase A-deficient mice
    • Itoh, T., Tanioka, M., Yoshida, H., Yoshioka, T., Nishimoto, H., and Itohara, S. (1998). Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res. 58, 1048-1051.
    • (1998) Cancer Res. , vol.58 , pp. 1048-1051
    • Itoh, T.1    Tanioka, M.2    Yoshida, H.3    Yoshioka, T.4    Nishimoto, H.5    Itohara, S.6
  • 24
    • 0026502754 scopus 로고
    • Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues
    • Jakeman, L.B., Winer, J., Bennett, G.L., Altar, C.A., and Ferrara, N. (1992). Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J. Clin. Invest. 89, 244-253.
    • (1992) J. Clin. Invest. , vol.89 , pp. 244-253
    • Jakeman, L.B.1    Winer, J.2    Bennett, G.L.3    Altar, C.A.4    Ferrara, N.5
  • 25
    • 0035124888 scopus 로고    scopus 로고
    • Matrix metalloproteinases in human diabetic and nondiabetic vitreous
    • Jin, M., Kashiwagi, K., Iizuka, Y., Tanaka, Y., Imai, M., and Tsukahara, S. (2001). Matrix metalloproteinases in human diabetic and nondiabetic vitreous. Retina 21, 28-33.
    • (2001) Retina , vol.21 , pp. 28-33
    • Jin, M.1    Kashiwagi, K.2    Iizuka, Y.3    Tanaka, Y.4    Imai, M.5    Tsukahara, S.6
  • 26
    • 0027428644 scopus 로고
    • The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells
    • Kaipainen, A., Korhonen, J., Pajusola, K., Aprelikova, O., Persico, M.G., Terman, B.I., and Alitalo, K. (1993). The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells. J. Exp. Med. 178, 2077-2088.
    • (1993) J. Exp. Med. , vol.178 , pp. 2077-2088
    • Kaipainen, A.1    Korhonen, J.2    Pajusola, K.3    Aprelikova, O.4    Persico, M.G.5    Terman, B.I.6    Alitalo, K.7
  • 27
    • 0027421333 scopus 로고
    • Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
    • Kendall, R.L., and Thomas, K.A. (1993). Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc. Natl. Acad. Sci. USA 90, 10705-10709.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10705-10709
    • Kendall, R.L.1    Thomas, K.A.2
  • 29
    • 0032570774 scopus 로고    scopus 로고
    • Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors
    • Kondo, K., Hiratsuka, S., Subbalakshmi, E., Matsushime, H., and Shibuya, M. (1998). Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors. Gene 208, 297-305.
    • (1998) Gene , vol.208 , pp. 297-305
    • Kondo, K.1    Hiratsuka, S.2    Subbalakshmi, E.3    Matsushime, H.4    Shibuya, M.5
  • 30
    • 0005419856 scopus 로고    scopus 로고
    • Significant expression of vascular endothelial growth factor/vascular permeability factor in mouse ascites tumors
    • Luo, J.C., Yamaguchi, S., Shinkai, A., Shitara, K., and Shibuya, M. (1998). Significant expression of vascular endothelial growth factor/vascular permeability factor in mouse ascites tumors. Cancer Res. 58, 2652-2660.
    • (1998) Cancer Res. , vol.58 , pp. 2652-2660
    • Luo, J.C.1    Yamaguchi, S.2    Shinkai, A.3    Shitara, K.4    Shibuya, M.5
  • 31
    • 0026052391 scopus 로고
    • Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor
    • Maglione, D., Guerriero, V., Viglietto, G., Delli-Bovi, P., and Persico, M.G. (1991). Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc. Natl. Acad. Sci. USA 88, 9267-9271.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 9267-9271
    • Maglione, D.1    Guerriero, V.2    Viglietto, G.3    Delli-Bovi, P.4    Persico, M.G.5
  • 32
    • 0025998533 scopus 로고
    • A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit
    • Matthews, W., Jordan, C.T., Gavin, M., Jenkins, N.A., Copeland, N.G., and Lemischka, I.R. (1991). A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc. Natl. Acad. Sci. USA 88, 9026-9030.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 9026-9030
    • Matthews, W.1    Jordan, C.T.2    Gavin, M.3    Jenkins, N.A.4    Copeland, N.G.5    Lemischka, I.R.6
  • 34
    • 0029021904 scopus 로고
    • Endothelial receptor tyrosine kinases involved in angiogenesis
    • Mustonen, T., and Alitalo, K. (1995). Endothelial receptor tyrosine kinases involved in angiogenesis. J. Cell Biol. 129, 895-898.
    • (1995) J. Cell Biol. , vol.129 , pp. 895-898
    • Mustonen, T.1    Alitalo, K.2
  • 35
    • 0030785679 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases and their inhibitors in human bronchopulmonary carcinomas: Quantificative and morphological analyses
    • Nawrocki, B., Polette, M., Marchand, V., Monteau, M., Gillery, P., Tournier, J.M., and Birembaut, P. (1997). Expression of matrix metalloproteinases and their inhibitors in human bronchopulmonary carcinomas: quantificative and morphological analyses. Int. J. Cancer 72, 556-564.
    • (1997) Int. J. Cancer , vol.72 , pp. 556-564
    • Nawrocki, B.1    Polette, M.2    Marchand, V.3    Monteau, M.4    Gillery, P.5    Tournier, J.M.6    Birembaut, P.7
  • 36
    • 0027503847 scopus 로고
    • Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis
    • Nicolson, G.L. (1993). Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis. Cancer Metastasis Rev. 12, 325-343.
    • (1993) Cancer Metastasis Rev. , vol.12 , pp. 325-343
    • Nicolson, G.L.1
  • 37
    • 0032553299 scopus 로고    scopus 로고
    • A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain
    • Ogawa, S., Oku, A., Sawano, A., Yamaguchi, S., Yazaki, Y., and Shibuya, M. (1998). A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain. J. Biol. Chem. 273, 31273-31282.
    • (1998) J. Biol. Chem. , vol.273 , pp. 31273-31282
    • Ogawa, S.1    Oku, A.2    Sawano, A.3    Yamaguchi, S.4    Yazaki, Y.5    Shibuya, M.6
  • 41
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    • Park, J.E., Chen, H.H., Winer, J., Houck, K.A., and Ferrara, N. (1994). Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J. Biol. Chem. 269, 25646-25654.
    • (1994) J. Biol. Chem. , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3    Houck, K.A.4    Ferrara, N.5
  • 42
    • 0032952694 scopus 로고    scopus 로고
    • Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma
    • Prontera, C., Mariani, B., Rossi, C., Poggi, A., and Rotilio, D. (1999). Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma. Int. J. Cancer 81, 761-766.
    • (1999) Int. J. Cancer , vol.81 , pp. 761-766
    • Prontera, C.1    Mariani, B.2    Rossi, C.3    Poggi, A.4    Rotilio, D.5
  • 43
    • 0027249239 scopus 로고
    • Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium
    • Quinn, T.P., Peters, K.G., De Vries, C., Ferrara, N., and Williams, L.T. (1993). Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc. Natl. Acad. Sci. USA 90, 7533-7537.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 7533-7537
    • Quinn, T.P.1    Peters, K.G.2    De Vries, C.3    Ferrara, N.4    Williams, L.T.5
  • 44
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau, W. (1997). Mechanisms of angiogenesis. Nature 386, 671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 46
    • 0030050025 scopus 로고    scopus 로고
    • Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor
    • Sawano, A., Takahashi, T., Yamaguchi, S., Aonuma, M., and Shibuya, M. (1996). Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor. Cell Growth Differ. 7, 213-221.
    • (1996) Cell Growth Differ. , vol.7 , pp. 213-221
    • Sawano, A.1    Takahashi, T.2    Yamaguchi, S.3    Aonuma, M.4    Shibuya, M.5
  • 47
    • 0031577563 scopus 로고    scopus 로고
    • The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma
    • Sawano, A., Takahashi, T., Yamaguchi, S., and Shibuya, M. (1997). The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma. Biochem. Biophys. Res. Commun. 238, 487-491.
    • (1997) Biochem. Biophys. Res. Commun. , vol.238 , pp. 487-491
    • Sawano, A.1    Takahashi, T.2    Yamaguchi, S.3    Shibuya, M.4
  • 48
    • 0028798083 scopus 로고
    • A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF
    • Seetharam, L., Gotoh, N., Maru, Y., Neufeld, G., Yamaguchi, S., and Shibuya, M. (1995). A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF. Oncogene 10, 135-147.
    • (1995) Oncogene , vol.10 , pp. 135-147
    • Seetharam, L.1    Gotoh, N.2    Maru, Y.3    Neufeld, G.4    Yamaguchi, S.5    Shibuya, M.6
  • 49
    • 0035003384 scopus 로고    scopus 로고
    • Structure and function of VEGF/VEGF-receptor system involved in angiogenesis
    • Shibuya, M. (2001). Structure and function of VEGF/VEGF-receptor system involved in angiogenesis. Cell Struct. Funct. 26, 25-35.
    • (2001) Cell Struct. Funct. , vol.26 , pp. 25-35
    • Shibuya, M.1
  • 50
    • 0025259592 scopus 로고
    • Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family
    • Shibuya, M., Yamaguchi, S., Yamane, A., Ikeda, T., Tojo, A., Matsushime, H., and Sato, M. (1990). Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 5, 519-524.
    • (1990) Oncogene , vol.5 , pp. 519-524
    • Shibuya, M.1    Yamaguchi, S.2    Yamane, A.3    Ikeda, T.4    Tojo, A.5    Matsushime, H.6    Sato, M.7
  • 52
    • 0033134622 scopus 로고    scopus 로고
    • Matrix metalloproteinases in angiogenesis: A moving target for therapeutic intervention
    • Stetler-Stevenson, W.G. (1999). Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention. J. Clin. Invest. 103, 1237-1241.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1237-1241
    • Stetler-Stevenson, W.G.1
  • 53
    • 0033118228 scopus 로고    scopus 로고
    • VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK- MAP kinase pathway for DNA synthesis in primary endothelial cells
    • Takahashi, T., Ueno, H., and Shibuya, M. (1999). VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK- MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 18, 2221-2230.
    • (1999) Oncogene , vol.18 , pp. 2221-2230
    • Takahashi, T.1    Ueno, H.2    Shibuya, M.3
  • 55
    • 0346963598 scopus 로고    scopus 로고
    • MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
    • Vu, T.H., Shipley, J.M., Bergers, G., Berger, J.E., Helms, J.A., Hanahan, D., Shapiro, S.D., Senior, R.M., and Werb, Z. (1998). MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93, 411-422.
    • (1998) Cell , vol.93 , pp. 411-422
    • Vu, T.H.1    Shipley, J.M.2    Bergers, G.3    Berger, J.E.4    Helms, J.A.5    Hanahan, D.6    Shapiro, S.D.7    Senior, R.M.8    Werb, Z.9
  • 57
    • 0027980356 scopus 로고
    • A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-1)
    • Yamane, A., Seetharam, L., Yamaguchi, S., Gotoh, N., Takahashi, T., Neufeld, G., and Shibuya, M. (1994). A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-1). Oncogene 9, 2683-2690.
    • (1994) Oncogene , vol.9 , pp. 2683-2690
    • Yamane, A.1    Seetharam, L.2    Yamaguchi, S.3    Gotoh, N.4    Takahashi, T.5    Neufeld, G.6    Shibuya, M.7
  • 58
    • 0027267037 scopus 로고
    • Molecular basis of tumor progression: Mechanisms of organ-specific tumor metastasis
    • Yeatman, T.J., and Nicolson, G.L. (1993). Molecular basis of tumor progression: mechanisms of organ-specific tumor metastasis. Semin. Surg. Oncol. 9, 256-263.
    • (1993) Semin. Surg. Oncol. , vol.9 , pp. 256-263
    • Yeatman, T.J.1    Nicolson, G.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.