Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases

Journal of Clinical Investigation

Volumn 111, Issue 5, 2003, Pages 707-716

  Eremina, Vera ^a   Sood, Manish ^a   Haigh, Jody ^a   Nagy, András ^a   Lajoie, Ginette ^b   Ferrara, Napoleone ^c   Gerber, Hans Peter ^c   Kikkawa, Yamato ^d   Miner, Jeffrey H ^d   Quaggin, Susan E ^a,e  

^a MOUNT SINAI HOSPITAL   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c GENENTECH INC   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE DELETION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GLOMERULOPATHY; GLOMERULUS; GLOMERULUS FILTRATION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KIDNEY DISEASE; KIDNEY FAILURE; KIDNEY INJURY; LETHALITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PODOCYTE; PREECLAMPSIA; PRIORITY JOURNAL; PROTEINURIA; SIGNAL TRANSDUCTION; UNITED STATES;

EID: 0037370325     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI17423     Document Type: Article

References (44)

1. Mundel, P., and Reiser, J. 1997. New aspects of podocyte cell biology. Kidney Blood Press. Res. 20:173-176.
2. Abrahamson, D.R. 1991. Glomerulogenesis in the developing kidney. Semin. Nepbrol. 11:375-389.
3. Kriz, W., and Lemley, K. 1999. The role of the podocyte in glomerulosclerosis. Curr. Opin. Nephrol. Hypertens. 8:489-497.
4. Kriz, W. 1997. Evolving role of the podocyte in chronic renal failure. Kidney Blood Press. Res. 20:180-183.
5. Shirato, I., et al. 1996. The development of focal segmental glomerulosclerosis in masugi nephritis is based on progressive podocyte damage. Virchows Arch. 429:255-273.
6. Coimbra, T.M., et al. 2000. Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes. Kidney Int 57:167-182.
7. Floege, J., et al. 1997. Age-related glomerulosclerosis and interstitial fibrosis in Milan normotensive rats: a podocyte disease. Kidney Int. 51:230-243.
8. Pagtalunan, M.E., et al. 1997. Podocyte loss and progressive glomerular injury in type II diabetes. J. Clin. Invest. 99:342-348.
9. Robert, B., Zhao, X., and Abrahamson, D.R. 2000. Coexpression of neuropilin-1, flk1, and VEGF(164) in developing and mature mouse kidney glomeruli. Am. J. Physiol. Renal Physiol. 279:F27S-F282.
10. Saxen, L., and Sariola, H. 1987. Organogenesis of the kidney. Pediatr. Nephrol. 1:385-392.
11. Carmeliet, P., et al. 1996. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 380:435-439.
12. Ferrara, N., et al. 1996. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature. 380:439-442.
13. Somlo, S., and Mundel, P. 2000. Getting a foothold in nephrotic syndrome. Nat. Genet. 24:333-335.
14. Laurinavicius, A., Hurwitz, S., and Rennke, H.G. 1999. Collapsing glomerulopathy in HIV and non-HIV patients: a clinicopathological and follow-up study. Kidney Int. 56:2203-2213.
15. Novak, A., Guo, C., Yang, W., Nagy, A., and Lobe, C.G. 2000. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis. 28:147-155.
16. Gerber, H.P., et al. 1999. VEGF is required for growth and survival in neonatal mice. Development. 126:1149-1159.
17. Eremina, V., Wong, M.A., Cui, S., Schwartz, L., and Quaggin, S.E. 2002. Glomerular-specific gene excision in vivo. J. Am. Soc. Nephrol. 13:788-793.
18. Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:680-685.
19. Wong, M.A., Cui, S., and Quaggin, S.E. 2000. Identification and characterization of a glomerular-specific promoter from the human nephrin gene. Am. J. Physiol. Renal Physiol. 279:F 1027-F1032.
20. Miner, J.H., and Li, C. 2000. Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane. Dev. Biol. 217:278-289.
21. Kincaid-Smith, P. 1991. The renal lesion of preeclampsia revisited. Am. J. Kidney Dis. 17:144-148.
22. McDonald, R., Wiggelinkhuizen, J., and Kaschula, R.O. 1971. The nephrotic syndrome in very young infants. Am. J. Dis. Child. 122:507-512.
23. Esser, S., et al. 1998. Vascular endothelial growth factor induces endothelial fenestrations in vitro. J. Cell Biol. 140:947-959.
24. Roberts, W.G., and Palade, G.E. 1995. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J. Cell Sci. 108:2369-2379.
25. Bielecki, D.A., Klonowska-Dziatkiewicz, E., Jarocki, S., and Urban, J. 2002. Growth factors in pregnancy complications with preeclampsia. Ginekol Pol. 73:422-429.
26. Bachelder, R.E., et al. 2001. Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res. 61:5736-5740.
27. Kitamoto, Y., Tokunaga, H., and Tomita, K. 1997. Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis. J. Clin. Invest. 99:2351-2357.
28. Mattot, V., et al. 2002. Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice. J. Am. Soc. Nephrol. 13:1548-1560.
29. Miquerol, L., Gertsenstein, M., Harpal, K., Rossant, J., and Nagy, A. 1999. Multiple developmental roles of VEGF suggested by a LacZtagged allele. Dev. Biol. 212:307-322.
30. Gengrinovitch, S., et al. 1999. Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165. J. Biol. Chem. 274:10816-10822.
31. Drake, C.J., and Little, C.D. 1995. Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization. Proc. Natl. Acad. Sci. U. S. A. 92:7657-7661.
32. Drake, C.J., and Little, C.D. 1999. VEGF and vascular fusion: implications for normal and pathological vessels. J. Histochem. Cytochem. 47:1351-1356.
33. Morini, M., et al. 2000. Kaposi's sarcoma cells of different etiologic origins respond to HIV-Tat through the Flk-1/KDR (VEGFR-2): relevance in AIDS-KS pathology. Biochem. Biophys. Res. Commun. 273:267-271.
34. Ganju, R.K., et al. 1998. Human immunodeficiency virus rat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells. J. Virol. 72:6131-6137.
35. Vene, R., Benelli, R., Noonan, D.M., and Albini, A. 2000. HIV-Tat dependent chemotaxis and invasion, key aspects oftat mediated pathogenesis. Clin. Exp. Metastasis. 18:533-538.
36. Marras, D., et al. 2002. Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy. Nat. Med. 8:522-526.
37. Barisoni, L., Kriz, W., Mundel, P., and D'Agati, V. 1999. The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J. Am. Soc. Nephrol. 10:51-61.
38. Bruggeman, L.A., et al. 1997. Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression. J. Clin. Invest. 100:84-92.
39. Conaldi, P.G., et al. 2002. Human immunodeficiency virus-1 tat induces hyperproliferation and dysregulation of renal glomerular epithelial cells. Am. J. Pathol. 161:53-61.
40. Husain, M., et al. 2002. HIV-1 Nef induces proliferation and anchorageindependent growth in podocytes. J. Am. Soc. Nephrol. 13:1806-1815.
41. Shahbazi, M., et al. 2002. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J. Am. Soc. Nephrol. 13:260-264.
42. Kim, Y.G., et al. 2000. Vascular endothelial growth factor accelerates renal recovery in experimental thrombotic microangiopathy. Kidney Int. 58:2390-2399.
43. Cha, D.R., et al. 2000. Role of vascular endothelial growth factor in diabetic nephropathy. Kidney Int. Suppl. 77:S104-S112.
44. Ostendorf, T., et al. 1999. VEGF(165) mediates glomerular endothelial repair. J. Clin. Invest. 104:913-923.