The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency

Journal of Biological Chemistry

Volumn 271, Issue 13, 1996, Pages 7788-7795

  Keyt, Bruce A ^a   Berleau, Lea T ^a   Nguyen, Hung V ^a   Chen, Helen ^a   Heinsohn, Henry ^a   Vandlen, Richard ^a   Ferrara, Napoleone ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; ELASTASE; HEPARIN; MITOGENIC AGENT; PLASMIN; PROTEIN TYROSINE KINASE; PROTEINASE; RECOMBINANT VASCULOTROPIN; THROMBIN; TRYPSIN; VASCULOTROPIN;

ADRENAL CORTEX; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATTLE; CHO CELL; ENDOTHELIUM CELL; MITOGENESIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ADRENAL CORTEX; ALTERNATIVE SPLICING; ANIMALS; BINDING, COMPETITIVE; CAPILLARIES; CATTLE; CELL DIVISION; CELLS, CULTURED; CHO CELLS; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; CRICETINAE; ENDOPEPTIDASES; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; ESCHERICHIA COLI; HUMANS; KINETICS; LYMPHOKINES; MACROMOLECULAR SUBSTANCES; PEPTIDE FRAGMENTS; PLASMIN; POLYMORPHISM, GENETIC; PROTEIN FOLDING; RECEPTORS, IGG; RECOMBINANT PROTEINS; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA; BOS TAURUS;

EID: 0029937679     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.13.7788     Document Type: Article

References (35)

1. Ferrara, N., and Henzel, W. J. (1989) Biochem. Biophys. Res. Commun. 161, 851-858
2. Ploüet, J., Schilling, J., and Gospodarowicz, D. (1989) EMBO J. 8, 3801-3807
3. Ferrara, N., Houck, K., Jakeman, L., and Leung, D. W. (1992) Endocr. Rev. 13, 18-32
4. Phillips, H. S., Hains, J., Leung, D. W., and Ferrara, N. (1990) Endocrinology 127, 965-968
5. Breier, G., Albrecht, U., Sterrer, S., and Risau, W. (1992) Development 114, 521-532
6. Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., and Ferrara, N. (1993) Nature 362, 841-844
7. Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., and Ferrara, N. (1989) Science 246, 1306-1309
8. Tischer, E., Mitchell, E., Hartman, T., Silva, M., Gospodarowicz, D., Fiddes, J., and Abraham, J. (1991) J. Biol. Chem. 266, 11947-11954
9. Houck, K. A., Ferrara, N., Winer, J., Cachianes, G., Li, B., and Leung, D. W. (1991) Mol. Endocrinol. 5, 1806-1814
10. Houck, K. A., Leung, D. W., Rowland, A. M., Winer, J., and Ferrara, N. (1992) J. Biol. Chem. 267, 26031-26037
11. Park, J. E., Keller, G. A., and Ferrara, N. (1993) Mol. Biol. Cell 4, 1317-1326
12. Park, J. E., Chen, H., Winer, J., Houck, K. A., and Ferrara, N. (1994) J. Biol. Chem. 269, 25646-25654
13. Ferrara, N., Winer, J., Burton, T., Rowland, A., Siegel, M., Phillips, H. S., Terrell, T., Keller, G. A., and Levinson, A. D. (1993) J. Clin. Invest. 91, 160-170
14. Hunter, W. M., and Greenwood, F. C. (1962) Nature 194, 495-496
15. Crestfield, A. M., Moore, S., and Stein, W. H. (1963) J. Biol. Chem. 238, 622-627
16. Laemmli, U. K. (1970) Nature 227, 680-685
17. Oakley, B. R., Kirsch, D. R., and Morris, N. R. (1980) Anal. Biochem. 105, 361-36326
18. Tessler, S., Rockwell, P., Hicklin, D., Cohen, T., Levi, B.-Z., Witte, L., Lemischka, I. R., and Neufeld, G. (1994) J. Biol. Chem. 269, 12456-12461
19. Matrisian, L. M., and Hogan, B. L. (1990) Curr. Top. Dev. Biol. 24, 219-259
20. Mignatti, P., Tsuboi, R., Robbins, E., and Rifkin, D. B. (1989) J. Cell Biol. 108, 671-682
21. Vlodavsky, I., Folkman, J., Sullivan, R., Fridman, R., Ishai-Michaeli, R., Sasse, J., and Klagsbrun, M. N. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 2292-2296
22. Raines, E. W., and Ross, R. (1992) J. Cell Biol. 116, 533-543
23. Gordon, M. Y., Riley, G. P., Watt, S. M., and Greaves, M. F. (1987) Nature 326, 403-405
24. Andres, J. L., Stanley, K., Cheifetz, S., and Massague, J. (1989) J. Cell Biol. 109, 3137-3145
25. Rathjen, P. D., Toth, S., Willis, A., Heath, J. K., and Smith, A. G. (1990) Cell 62, 1105-1114
26. Gitay-Goren, H., Soker, S., Vlodavsky, I., and Neufeld, G. (1992) J. Biol. Chem. 267, 6093-6098
27. Cohen, T., Gitay-Goren, H., Sharon, R., Shibuya, M., Halaban, R., Levi, B.-Z., and Neufeld, G. (1995) J. Biol. Chem. 270, 11322-11326
28. Waltenberger, J., Claesson-Welsh, L., Siegbahn, A., Shibuya, M., and Heldin, C.-H. (1994) J. Biol. Chem. 269, 26988-26995
29. Soker, S., Goldstaub, D., Svahn, C. M., Vlodavsky, I., Levi, B.-Z., and Neufeld, G. (1994) Biochem. Biophys. Res. Commun. 203, 1339-1347
30. Sasisekharan, R., Moses, M. M., Nugent, M. A., Cooney, C. L., and Langer, R. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 1524-1528
31. Levy, A. P., Levy, N. S., Wegner, S., and Goldberg, M. A. (1995) J. Biol. Chem. 270, 13333-13340
32. Maglione, D., Guerriero, V., Vigliette, G., Delli-Bovi, P., and Persico, M. G. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 9267-9271
33. Maglione, D., Guerriero, V., Vigliette, G., Ferrara, M. G., Aprelikova, O., Alitalo, K., Del Vecchio, S., Lei, K. J., Chou, J. C., and Persico, M. G. (1993) Oncogens 8, 925-931
34. DiSalvo, J., Bayne, M. L., Conn, G., Kwok, P. W., Trivedi, P. G., Soderman, D. D., Palisi, T. M., Sullivan, K. A., and Thomas, K. A. (1995) J. Biol. Chem. 270, 7717-7723
35. Oefner, C., D'Arcy, A., Winkler, F. K., Eggimann, B., and Hosang, M. (1992) EMBO J. 11, 3921-3926