Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated γ-secretase activity

Annals of the New York Academy of Sciences

Volumn 920, Issue , 2000, Pages 223-226

  Berezovska, Oksana ^a   Jack, Christine ^b   McLean, Pamela ^c   Aster, Jon C ^b   Hicks, Carol ^a   Weiming, X I A ^b   Wolfe, Michael S ^c   Weinmaster, Gerry ^b   Selkoe, Dennis J ^c   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA SECRETASE; PRESENILIN 1;

ANIMAL CELL; CARBOXY TERMINAL SEQUENCE; CHO CELL; CHROMOSOME TRANSLOCATION; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; GENETIC TRANSFECTION; LIGAND BINDING; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DOMAIN; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALIA; MAMMALIA;

EID: 0034527764     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06926.x     Document Type: Conference Paper

References (15)

1. 42 deposition and severe cerebellar pathology
2. The impact of different presenilin 1 and presenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease (AD) brain: Evidence for other phenotype modifying factors
3. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
4. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
5. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
6. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch
7. A loss of function mutation of presenilin-2 interferes with amyloid-peptide production and Notch signaling
8. Notch receptor activation inhibits oligodendrocyte differentiation
9. Notch1 inhibits neurite outgrowth in postmitotic primary neurons
10. A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity
11. Effect of PSI deficiency on membrane protein trafficking in neurons
12. Effect of Sel-12 presenilin on Lin-12 localization and function in Caenorhabditis elegans
13. Drosophila presenilin is required for neuronal differentiation and affects Notch subcellular localization and signaling
14. Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants
15. Calcium depletion dissociates and activates heterodimeric Notch receptors