Gene Vaccines

Annals of Internal Medicine

Volumn 138, Issue 7, 2003, Pages

  Srivastava, Indresh K ^a   Liu, Margaret A ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b TRANSGENE S A   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALGINIC ACID; ANTIBODY; ANTIGEN; CD8 ANTIGEN; DNA; DNA VACCINE; EPITOPE; GAMMA INTERFERON; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; LIPID; LIVE VACCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MICROSPHERE; NAKED DNA; PARASITE ANTIGEN; PHOSPHORYL LIPID A; PLASMID DNA; POLYETHYLENEIMINE; PROTEIN; QS 21; RECOMBINANT PROTEIN; SECRETORY IMMUNOGLOBULIN; UNINDEXED DRUG; VACCINE; VACCINIA VACCINE; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN; VIRUS VACCINE; VIRUS VECTOR;

ANTIGEN PRESENTING CELL; B LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL TRIAL; CYTOTOXIC T LYMPHOCYTE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SAFETY; GENE; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IMMUNOTHERAPY; INFECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK; T LYMPHOCYTE; VIRUS PARTICLE; ANIMAL; ANTIBODY PRODUCTION; BACTERIUM; DISEASE MODEL; GENE VECTOR; HELPER CELL; INFECTION CONTROL; NEOPLASM; PHYSIOLOGY; VIRUS;

ANIMALS; ANTIBODY FORMATION; BACTERIA; CLINICAL TRIALS; DISEASE MODELS, ANIMAL; GENETIC VECTORS; HUMANS; INFECTION CONTROL; NEOPLASMS; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, HELPER-INDUCER; VACCINES, DNA; VIRUSES;

EID: 0037389073     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-138-7-200304010-00011     Document Type: Review

References (110)

1. Braciale TJ, Morrison LA, Sweetser MT, Sambrook J, Gething MJ, Braciale VL. Antigen presentation pathways to class I and class II MHC-restricted T lymphocytes. Immunol Rev. 1987;98:95-114. [PMID: 2443444]
2. McDonnell WM, Askari FK. DNA vaccines. N Engl J Med. 1996;334:42-5. [PMID: 7494571]
3. Donnelly JJ, Liu MA, Ulmer JB. Antigen presentation and DNA vaccines. Am J Respir Crit Care Med. 2000;162:S190-3. [PMID: 11029393]
4. Fu TM, Ulmer JB, Caulfield MJ, Deck RR, Friedman A, Wang S, et al. Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes. Mol Med. 1997;3:362-71. [PMID: 9234241]
5. Stevens EJ, Peakman M. Enhanced T cell proliferation and increased responder frequency following delivery of antigen to the antigen-presenting cell; B cell dependency and use in detection of autoreactive T cells. J Immunol Methods. 1998;215:59-70. [PMID: 9744748]
6. Johnson RP. Live attenuated AIDS vaccines: hazards and hopes. Nat Med. 1999;5:154-5. [PMID: 9930861]
7. Dietrich G. Current status and future perspectives of DNA vaccine delivery by attenuated intracellular bacteria. Arch Immunol Ther Exp (Warsz). 2000;48:177-82. [PMID: 10912622]
8. Medina E, Guzmán CA. Use of live bacterial vaccine vectors for antigen delivery: potential and limitations. Vaccine. 2001;19:1573-80. [PMID: 11166877]
9. Sizemore DR, Branstrom AA, Sadoff JC. Attenuated Shigella as a DNA delivery vehicle for DNA-mediated immunization. Science. 1995;270:299-302. [PMID: 7569980]
10. Noriega FR, Losonsky G, Lauderbaugh C, Liao FM, Wang JY, Levine MM. Engineered deltaguaB-A deltavirG Shigella flexneri 2a strain CVD 1205: construction, safety, immunogenicity, and potential efficacy as a mucosal vaccine. Infect Immun. 1996;64:3055-61. [PMID: 8757833]
11. Fennelly GJ, Khan SA, Abadi MA, Wild TF, Bloom BR. Mucosal DNA vaccine immunization against measles with a highly attenuated Shigellaflexneri vector. J Immunol. 1999;162:1603-10. [PMID: 9973419]
12. Tite JP, Gao XM, Hughes-Jenkins CM, Lipscombe M, O'Callaghan D, Dougan G, et al. Anti-viral immunity induced by recombinant nucleoprotein of influenza A virus. III. Delivery of recombinant nucleoprotein to the immune system using attenuated Salmonella typhimurium as a live carrier. Immunology. 1990;70:540-6. [PMID: 2168340]
13. Hone DM, Lewis GK, Beier M, Harris A, McDaniels T, Fouts TR. Expression of human immunodeficiency virus antigens in an attenuated Salmonella typhi vector vaccine. Dev Biol Stand. 1994;82:159-62. [PMID: 7958470]
14. Tacket CO, Sztein MB, Wasserman SS, Losonsky G, Kotloff KL, Wyant TL, et al. Phase 2 clinical trial of attenuated Salmonella enterica serovar typhi oral live vector vaccine CVD 908-htrA in U.S. volunteers. Infect Immun. 2000;68:1196-201. [PMID: 10678926]
15. Frankel FR, Hegde S, Lieberman J, Paterson Y. Induction of cell-mediated immune responses to human immunodeficiency virus type 1 Gag protein by using Listeria monocytogenes as a live vaccine vector. J Immunol. 1995;155:4775-82. [PMID: 7594479]
16. Baba TW, Liska V, Khimani AH, Ray NB, Dailey PJ, Penninck D, et al. Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques. Nat Med. 1999;5:194-203. [PMID: 9930868]
17. Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, et al. Direct gene transfer into mouse muscle in vivo. Science. 1990;247:1465-8. [PMID: 1690918]
18. Ulmer JB, Donnelly JJ, Parker SE, Rhodes GH, Felgner PL, Dwarki VJ, et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science. 1993;259:1745-9. [PMID: 8456302]
19. Tang DC, DeVit M, Johnston SA. Genetic immunization is a simple method for eliciting an immune response. Nature. 1992;356:152-4. [PMID: 1545867]
20. Fuller DH, Haynes JR. A qualitative progression in HIV type 1 glycoprotein 120-specific cytotoxic cellular and humoral immune responses in mice receiving a DNA-based glycoprotein 120 vaccine. AIDS Res Hum Retroviruses. 1994;10:1433-41. [PMID: 7888198]
21. Pertmer TM, Roberts TR, Haynes JR. Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery. J Virol. 1996;70:6119-25. [PMID: 8709236]
22. Feltquate DM, Heaney S, Webster RG, Robinson HL. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J Immunol. 1997;158:2278-84. [PMID: 9036975]
23. Schirmbeck R, Böhm W, Ando K, Chisari FV, Reimann J. Nucleic acid vaccination primes hepatitis B virus surface antigen-specific cytotoxic T lymphocytes in nonresponder mice. J Virol. 1995;69:5929-34. [PMID: 7666497]
24. Kuhröber A, Wild J, Pudollek HP, Chisari FV, Reimann J. DNA vaccination with plasmids encoding the intracellular (HBcAg) or secreted (HBeAg) form of the core protein of hepatitis B virus primes T cell responses to two overlapping Kb- and Kd-restricted epitopes. Int Immunol. 1997;9:1203-12. [PMID: 9263018]
25. Shiver JW, Perry HC, Davies ME, Freed DC, Liu MA. Cytotoxic T lymphocyte and helper T cell responses following HIV polynucleotide vaccination. Ann N Y Acad Sci. 1995;772:198-208. [PMID: 8546393]
26. Liu MA, Yasutomi Y, Davies ME, Perry HC, Freed DC, Letvin NL, et al. Vaccination of mice and nonhuman primates using HIV-gene-containing DNA. Antibiot Chemother. 1996;48:100-4. [PMID: 8726511]
27. Shiver JW, Davies ME, Yasutomi Y, Perry HC, Freed DC, Letvin NL, et al. Anti-HIV env immunities elicited by nucleic acid vaccines. Vaccine. 1997;15:884-7. [PMID: 9234539]
28. Boyer JD, Chattergoon M, Shah A, Ginsberg R, MacGregor RR, Weiner DB. HIV-1 DNA based vaccine induces a CD8 mediated cross-clade cytolytic T cell response. Dev Biol Stand. 1998;95:147-53. [PMID: 9855425]
29. Thomson SA, Sherritt MA, Medveczky J, Elliott SL Moss DJ, Fernando GJ, et al. Delivery of multiple CD8 cytotoxic T cell epitopes by DNA vaccination. J Immunol. 1998;160:1717-23. [PMID: 9469429]
30. Yokoyama M, Zhang J, Whitton JL. DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection. J Virol. 1995;69:2684-8. [PMID: 7884923]
31. Martins LP, Lau LL, Asano MS, Ahmed R. DNA vaccination against persistent viral infection. J Virol. 1995;69:2574-82. [PMID: 7884908]
32. Manickan E, Yu Z, Rouse RJ, Wire WS, Rouse BT. Induction of protective immunity against herpes simplex virus with DNA encoding the immediate early protein ICP 27. Viral Immunol. 1995;8:53-61. [PMID: 8825290]
33. Donnelly JJ, Ulmer JB, Liu MA. Protective efficacy of intramuscular immunization with naked DNA. Ann N Y Acad Sci. 1995;772:40-6. [PMID: 8546412]
34. Allen TM, Vogel TU, Fuller DH, Mothé BR, Steffen S, Boyson JE, et al. Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen. J Immunol. 2000;164:4968-78. [PMID: 10779808]
35. Amara RR, Villinger F, Altman JD, Lydy SL, O'Neil SP, Staprans SI, et al. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/ MVA vaccine. Science. 2001;292:69-74. [PMID: 11393868]
36. Barouch DH, Craiu A, Santra S, Egan MA, Schmitz JE, Kuroda MJ, et al. Elicitation of high-frequency cytotoxic T-lymphocyte responses against both dominant and subdominant simian-human immunodeficiency virus epitopes by DNA vaccination of rhesus monkeys. J Virol. 2001;75:2462-7. [PMID: 11160750]
37. Wang R, Doolan DL, Le TP, Hedstrom RC, Coonan KM, Charoenvit Y, et al. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science. 1998;282:476-80. [PMID: 9774275]
38. Yankauckas MA, Morrow JE, Parker SE, Abai A, Rhodes GH, Dwarki VJ, et al. Long-term anti-nucleoprotein cellular and humoral immunity is induced by intramuscular injection of plasmid DNA containing NP gene. DNA Cell Biol. 1993;12:771-6. [PMID: 7692877]
39. Wang B, Boyer J, Srikantan V, Coney L, Carrano R, Phan C, et al. DNA inoculation induces neutralizing immune responses against human immunodeficiency virus type 1 in mice and nonhuman primates. DNA Cell Biol. 1993;12:799-805. [PMID: 8216851]
40. Richmond JF, Lu S, Santoro JC, Weng J, Hu SL, Montefiori DC, et al. Studies of the neutralizing activity and avidity of anti-human immunodeficiency virus type 1 Env antibody elicited by DNA priming and protein boosting. J Virol. 1998;72:9092-100. [PMID: 9765454]
41. Ourmanov I, Bilska M, Hirsch VM, Montefiori DC. Recombinant modified vaccinia virus ankara expressing the surface gpl20 of simian immunodeficiency virus (SIV) primes for a rapid neutralizing antibody response to SIV infection in macaques. J Virol. 2000;74:2960-5. [PMID: 10684319]
42. Barnett SW, Lu S, Srivastava I, Cherpelis S, Gettie A, Blanchard J, et al. The ability of an oligomeric human immunodeficiency virus type 1 (HIV-1) envelope antigen to elicit neutralizing antibodies against primary HIV-1 isolates is improved following partial deletion of the second hypervariable region. J Virol. 2001;75:5526-40. [PMID: 11356960]
43. + T-cell-depleted rhesus macaques. J Virol. 2001;75:1547-50. [PMID: 11152527]
44. Davis HL, Michel ML, Whalen RG. DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Hum Mol Genet. 1993;2:1847-51. [PMID: 8281146]
45. Xiang ZQ, Spitalnik S, Tran M, Wunner WH, Cheng J, Ertl HC. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology. 1994;199:132-40. [PMID: 8116236]
46. Lodmell DL, Ray NB, Parnell MJ, Ewalt LC, Hanlon CA, Shaddock JH, et al. DNA immunization protects nonhuman primates against rabies virus. Nat Med. 1998;4:949-52. [PMID: 9701249]
47. Manickan E, Rouse RJ, Yu Z, Wire WS, Rouse BT. Genetic immunization against herpes simplex virus. Protection is mediated by CD4+T lymphocytes. J Immunol. 1995;155:259-65. [PMID: 7602102]
48. Ghiasi H, Cai S, Slanina S, Nesburn AB, Wechsler SL. Vaccination of mice with herpes simplex virus type 1 glycoprotein D DNA produces low levels of protection against lethal HSV-1 challenge. Antiviral Res. 1995;28:147-57. [PMID: 8585768]
49. McClements WL, Armstrong ME, Keys RD, Liu MA. Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease. Proc Nad Acad Sci U S A. 1996;93:11414-20. [PMID: 8876149]
50. Bourne N, Stanberry LR, Bernstein DI, Lew D. DNA immunization against experimental genital herpes simplex virus infection. J Infect Dis. 1996;173:800-7. [PMID: 8603957]
51. Donnelly JJ, Martinez D, Jansen KU, Ellis RW, Montgomery DL, Liu MA. Protection against papillomavirus with a polynudeotide vaccine. J Infect Dis. 1996;173:314-20. [PMID: 8568291]
52. Sundaram P, Xiao W, Brandsma JL. Particle-mediated delivery of recombinant expression vectors to rabbit skin induces high-titered polyclonal antisera (and circumvents purification of a protein immunogen). Nucleic Acids Res. 1996;24:1375-7. [PMID: 8614644]
53. Major ME, Vitvitski L, Mink MA, Schleef M, Whalen RG, Trépo C, et al. DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid. J Virol. 1995;69:5798-805. [PMID: 7637024]
54. Lagging LM, Meyer K, Hoft D, Houghton M, Belshe RB, Ray R. Immune responses to plasmid DNA encoding the hepatitis C virus core protein. J Virol. 1995;69:5859-63. [PMID: 7637033]
55. Kuhöber A, Pudollek HP, Reifenberg K, Chisari FV, Schlicht HJ, Reimann J, et al. DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice. J Immunol. 1996; 156:3687-95. [PMID: 8621903]
56. Lai WC, Bennett M, Johnston SA, Barry MA, Pakes SP. Protection against Mycoplasma pulmonis infection by genetic vaccination. DNA Cell Biol. 1995;14:643-51. [PMID: 7626224]
57. Huygen K, Content J, Denis O, Montgomery DL, Yawman AM, Deck RR, et al. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nat Med. 1996;2:893-8. [PMID: 8705859]
58. Tascon RE, Colston MJ, Ragno S, Stavropoulos E, Gregory D, Lowrie DB. Vaccination against tuberculosis by DNA injection. Nat Med. 1996;2:888-92. [PMID: 8705858]
59. Ulmer JB, Liu MA, Montgomery DL, Yawman AM, Deck RR, DeWitt CM, et al. Expression and immunogenicity of Mycobacterium tuberculosis antigen 85 by DNA vaccination. Vaccine. 1997;15:792-4. [PMID: 9234515]
60. Sedegah M, Hedstrom R, Hobart P, Hoffman SL. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc Natl Acad Sci U S A. 1994;91:9866-70. [PMID: 7937907]
61. Xu D, Liew FY. Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major. Immunology. 1995;84:173-6. [PMID: 7750991]
62. Yang W, Waine GJ, McManus DP. Antibodies to Schistosoma japonicum (Asian bloodfluke) paramyosin induced by nucleic acid vaccination. Biochem Biophys Res Commun. 1995;212:1029-39. [PMID: 7626089]
63. Mitchell WM, Rosenbloom ST, Gabriel J. Induction of mucosal anti-HIV antibodies by facilitated transfection of airway epithelium with lipospermine/DNA complexes. Immunotechnology. 1995;1:211-9. [PMID: 9373349]
64. Sasaki S, Tsuji T, Asakura Y, Fukushima J, Okuda K. The search for a potent DNA vaccine against AIDS: the enhancement of immunogenicity by chemical and genetic adjuvants. Anticancer Res. 1998;18:3907-15. [PMID: 9854503]
65. Jones DH, Corris S, McDonald S, Clegg JC, Farrar GH. Poly(DL-lactideco-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration. Vaccine. 1997;15:814-7. [PMID: 9234522]
66. Orson FM, Kinsey BM, Hua PJ, Bhogal BS, Densmore CL, Barry MA. Genetic immunization with lung-targeting macroaggregated polyethyleneimine-albumin conjugates elicits combined systemic and mucosal immune responses. J Immunol. 2000;164:6313-21. [PMID: 10843685]
67. Mittal SK, Aggarwal N, Sailaja G, van Olphen A, HogenEsch H, North A, et al. Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: effect of route of inoculation on immune response. Vaccine. 2000;19:253-63. [PMID: 10930680]
68. Wang SW, Kozlowski PA, Schmelz G, Manson K, Wyand MS, Glickman R, et al. Effective induction of simian immunodeficiency virus-specific systemic and mucosal immune responses in primates by vaccination with proviral DNA producing intact but noninfectious virions. J Virol. 2000;74:10514-22. [PMID: 11044096]
69. Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc Natl Acad Sci U S A. 1993;90:11478-82. [PMID: 8265577]
70. Webster RG, Fynan EF, Santoro JC, Robinson H. Protection of ferrets against influenza challenge with a DNA vaccine to the haemagglutinin. Vaccine. 1994;12:1495-8. [PMID: 7879412]
71. Donnelly JJ, Friedman A, Martinez D, Montgomery DL, Shiver JW, Motzel SL, et al. Preclinical efficacy of a prototype DNA vaccine: enhanced protection against antigenic drift in influenza virus. Nat Med. 1995;1:583-7. [PMID: 7585127]
72. Prince AM, Whalen R, Brotman B. Successful nucleic acid based immunization of newborn chimpanzees against hepatitis B virus. Vaccine. 1997;15:916-9. [PMID: 9234547]
73. Hoffman SL, Sedegah M, Hedstrom RC. Protection against malaria by immunization with a Plasmodium yoelii circumsporozoite protein nucleic acid vaccine. Vaccine. 1994;12:1529-33. [PMID: 7879419]
74. Sedegah M, Jones TR, Kaur M, Hedstrom R, Hobart P, Tine JA, et al. Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine. Proc Nad Acad Sci U S A. 1998;95:7648-53. [PMID: 9636204]
75. Sedegah M, Weiss W, Sacci JB Jr, Charoenvit Y, Hedstrom R, Gowda K, et al. Improving protective immunity induced by DNA-based immunization: priming with antigen and GM-CSF-encoding plasmid DNA and boosting with antigen-expressing recombinant poxvirus. J Immunol. 2000;164:5905-12. [PMID: 10820272]
76. Wang B, Boyer JD, Ugen KE, Srikantan V, Ayyaroo V, Agadjanyan MG, et al. Nucleic acid-based immunization against HIV-I: induction of protective in vivo immune responses. AIDS. 1995;9 Suppl A:S159-70. [PMID: 8819582]
77. Fuller DH, Simpson L, Cole KS, Clements JE, Panicali DL, Montelaro RC, et al. Gene gun-based nucleic acid immunization alone or in combination with recombinant vaccinia vectors suppresses virus burden in rhesus macaques challenged with a heterologous SIV. Immunol Cell Biol. 1997;75:389-96. [PMID: 9315483]
78. Haigwood NL, Pierce CC, Robertson MN, Watson AJ, Montefiori DC, Rabin M, et al. Protection from pathogenic SIV challenge using multigenic DNA vaccines. Immunol Lett. 1999;66:183-8. [PMID: 10203053]
79. Barouch DH, Santra S, Schmitz JE, Kuroda MJ, Fu TM, Wagner W, et al. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science. 2000;290:486-92. [PMID: 11039923]
80. Letvin NL, Montefiori DC, Yasutomi Y, Perry HC, Davies ME, Lekutis C, et al. Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination. Proc Nad Acad Sci U S A. 1997;94:9378-83. [PMID: 9256490]
81. +T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nat Med. 1998;4:397-402. [PMID: 9546783]
82. Calarota SA, Kjerrström A, Islam KB, Wahren B. Gene combination raises broad human immunodeficiency virus-specific cytotoxicity. Hum Gene Ther. 2001;12:1623-37. [PMID: 11535166]
83. +T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine. Vaccine. 2000;19:764-78. [PMID: 11115698]
84. MacGregor RR, Boyer JD, Ugen KE, Lacy KE, Gluckman SJ, Bagarazzi ML, et al. First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response. J Infect Dis. 1998;178:92-100. [PMID: 9652427]
85. MacGregor RR, Boyer JD, Ciccarelli RB, Ginsberg RS, Weiner DB. Safety and immune responses to a DNA-based human immunodeficiency virus (HIV) type I env/rev vaccine in HIV-infected recipients: follow-up data [Letter]. J Infect Dis. 2000;181:406. [PMID: 10608800]
86. Calarota S, Bratt G, Nordlund S, Hinkula J, Leandersson AC, Sandström E, et al. Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients. Lancet. 1998;351:1320-5. [PMID: 9643795]
87. Boyer JD, Cohen AD, Vogt S, Schumann K, Nath B, Ahn L, et al. Vaccination of seronegative volunteers with a human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines. J Infect Dis. 2000;181:476-83. [PMID: 10669329]
88. Le TP, Coonan KM, Hedstrom RC, Charoenvit Y, Sedegah M, Epstein JE, et al. Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers. Vaccine. 2000;18:1893-901. [PMID: 10699338]
89. Reynolds FH Jr, Todaro GJ, Fryling C, Stephenson JR. Human transforming growth factors induce tyrosine phosphorylation of EGF receptors. Nature. 1981;292:259-62. [PMID: 6265789]
90. Cohen J. AIDS research. Merck reemerges with a bold AIDS vaccine effort. Science. 2001;292:24-5. [PMID: 11294193]
91. Haas J, Park EC, Seed B. Codon usage limitation in the expression of HIV-1 envelope glycoprotein. Curr Biol. 1996;6:315-24. [PMID: 8805248]
92. zur Megede J, Chen MC, Doe B, Schaefer M, Greer CE, Selby M, et al. Increased expression and immunogenicity of sequence-modified human immunodeficiency virus type 1 gag gene. J Virol. 2000;74:2628-35. [PMID: 10684277]
93. Iwasaki A, Stiernholm BJ, Chan AK, Berinstein NL, Barber BH. Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines. J Immunol. 1997;158:4591-601. [PMID: 9144471]
94. Kim JJ, Bagarazzi ML, Trivedi N, Hu Y, Kazahaya K, Wilson DM, et al. Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes. Nat Biotechnol. 1997;15:641-6. [PMID: 9219266]
95. Kim JJ, Yang JS, Dentchev T, Dang K, Weiner DB. Chemokine gene adjuvants can modulate immune responses induced by DNA vaccines. J Interferon Cytokine Res. 2000;20:487-98. [PMID: 10841077]
96. Mendoza RB, Cantwell MJ, Kipps TJ. Immunostimulatory effects of a plasmid expressing CD40 ligand (CD154) on gene immunization. J Immunol. 1997;159:5777-81. [PMID: 9550372]
97. Boyle JS, Brady JL, Lew AM. Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction. Nature. 1998;392:408-11. [PMID: 9537327]
98. Biragyn A, Tani K, Grimm MC, Weeks S, Kwak LW. Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity. Nat Biotechnol. 1999; 17:253-8. [PMID: 10096292]
99. Barouch DH, Craiu A, Kuroda MJ, Schmitz JE, Zheng XX, Santra S, et al. Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys. Proc Natl Acad Sci U S A. 2000;97:4192-7. [PMID: 10759543]
100. Fló J, Beatriz Perez A, Tisminetzky S, Baralle F. Superiority of intramuscular route and full length glycoprotein D for DNA vaccination against herpes simplex 2. Enhancement of protection by the co-delivery of the GM-CSF gene. Vaccine. 2000;18:3242-53. [PMID: 10869769]
101. Santra S, Barouch DH, Jackson SS, Kuroda MJ, Schmitz JE, Lifton MA, et al. Functional equivalency of B7-1 and B7-2 for costimulating plasmid DNA vaccine-elicited CTL responses. J Immunol. 2000;165:6791-5. [PMID: 11120800]
102. Widera G, Austin M, Rabussay D, Goldbeck C, Barnett SW, Chen M, et al. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J Immunol. 2000;164:4635-40. [PMID: 10779767]
103. Zucchelli S, Capone S, Fattori E, Folgori A, Di Marco A, Casimiro D, et al. Enhancing B- and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer. J Virol. 2000;74:11598-607. [PMID: 11090158]
104. Singh M, Briones M, Ott G, O'Hagan D. Cationic microparticles: A potent delivery system for DNA vaccines. Proc Natl Acad Sci U S A. 2000;97:811-6. [PMID: 10639162]
105. O'Hagan D, Singh M, Ugozzoli M, Wild C, Barnett S, Chen M, et al. Induction of potent immune responses by cationic microparticles with adsorbed human immunodeficiency virus DNA vaccines. J Virol. 2001;75:9037-43. [PMID: 11533167]
106. Krieg AM. An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA. J Lab Clin Med. 1996;128:128-33. [PMID: 8765208]
107. Krieg AM. Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA. Trends Microbiol. 1996;4:73-6. [PMID: 8820571]
108. Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen MD, et al. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science. 1996;273:352-4. [PMID: 8662521]
109. Klinman DM, Yamshchikov G, Ishigatsubo Y. Contribution of CpG motifs to the immunogenicity of DNA vaccines. J Immunol. 1997;158:3635-9. [PMID: 9103425]
110. Roman M, Martin-Orozco E, Goodman JS, Nguyen MD, Sato Y, Ronaghy A, et al. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med. 1997;3:849-54. [PMID: 9256274]