First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: Safety and host response

Journal of Infectious Diseases

Volumn 178, Issue 1, 1998, Pages 92-100

  MacGregor, Rob Roy ^a   Boyer, Jean D ^b   Ugen, Kenneth E ^b   Lacy, Kim E ^b   Gluckman, Stephen J ^b   Bagarazzi, Mark L ^b   Chattergoon, Michael A ^b   Baine, Yaela ^b   Higgins, Terry J ^b   Ciccarelli, Richard B ^b   Coney, Leslie R ^b   Ginsberg, Richard S ^b   Weiner, David B ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA ANTIBODY; DNA VACCINE; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 160; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; MUSCLE ENZYME; VIRUS RNA;

ADULT; ANTIBODY RESPONSE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CYTOTOXIC T LYMPHOCYTE; DRUG SAFETY; FEMALE; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOGENICITY; INTRAMUSCULAR DRUG ADMINISTRATION; LETHARGY; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MALE; NAUSEA; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TREATMENT OUTCOME; VIRUS CONCENTRATION;

EID: 0005457558     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/515613     Document Type: Article

References (14)

1. UNAIDS, WHO. UNAIDS fact sheet. Joint United Nations Programme on HIV/AIDS. 28 November 1996.
2. Belshe RB, Clements ML, Dolin R, et al. Safety and immunogenicity of a fully glycosylated recombinant gp160 human immunodeficiency virus type 1 vaccine in subjects at low risk of infection. J Infect Dis 1993; 168:1387-95.
3. Keefer MC, Graham BS, Belshe RB, et al. Studies of high doses of a human immunodeficiency virus type 1 recombinant glycoprotein 160 candidate vaccine in HIV type 1-seronegative humans. AIDS Res Hum Retroviruses 1994; 10:1713-23.
4. Schwartz DH, Gorse G, Clements ML, et al. Induction of HIV-1 neutralizing and syncytium-inhibiting antibodies in uninfected recipients of HIV-1 IIIB rgp120 subunit vaccine. Lancet 1993; 342:69-73.
5. Belshe RB, Graham BS, Keefer MC, et al. Neutralizing antibodies to HIV-1 in seronegative volunteers immunized with recombinant gp120 from the MN strain of HIV-1. JAMA 1994; 272:475-80.
6. Biselli R, Loomis LD, Bono VD, Burke DS, Redfield RR, Birx DL. Immunization of HIV-infected patients with rgp160: modulation of anti-rgp120 antibody spectrotype. J AIDS 1994; 7:1016-24.
7. Loomis LD, Deal CD, Kersey KS, Burke DS, Redfield RR, Birx DL. Humoral responses to linear epitopes on the HIV-1 envelope in seropositive volunteers after vaccine therapy with rgp160. J AIDS 1995; 10:13-7.
8. Pantaleo G, Menzo S, Vaccarezza M, et. al. Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. N Engl J Med 1995; 332:209-16.
9. Rinaldo C, Huang X, Fan Z, et al. High levels of anti-HIV-1 memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1 infected long-term nonprogressors. J Virol 1995; 69:5838-42.
10. Ugen KE, Srikantan V, Goedert JJ, Nelson RP Jr, Williams WV, Weiner DB. Vertical transmission of human immunodeficiency virus type 1: seroreactivity by maternal antibodies to the carboxy region of the gp41 envelope glycoprotein. J Infect Dis 1997; 175:63-9.
11. Ugen KE, Goedert JJ, Boyer J, et al. Vertical transmission of HIV infection. Reactivity of maternal sera with glycoprotein 120 and 41 peptides from HIV type I. J Clin Invest 1992; 89:1923-30.
12. Rossi P, Moschese V, Broliden P, et al. Presence of maternal antibodies to human immunodeficiency virus 1 envelope glycoprotein gp120 epitopes correlates with the uninfected status of children born to seropositive mothers. Proc Natl Acad Sci USA 1989; 86:8055-8.
13. Goedert J, Mendez H, Drummond J, et al. Mother-to-infant transmission of human immunodeficiency virus type 1: association with prematurity or low anti-gp120. Lancet 1989; 2:1351-4.
14. Rosenberg ES, Billings JM, Caliendo AM, et al. Vigorous HIV-1 specific CD4 T-cell responses associated with control of viremia. Science 1997: 278:1447-50.