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Volumn 18, Issue 5 D, 1998, Pages 3907-3915

The search for a potent DNA vaccine against AIDS: The enhancement of immunogenicity by chemical and genetic adjuvants

Author keywords

Adjuvant; AIDS; Cytokine; DNA vaccine; Immunomodulatory molecules

Indexed keywords

BESTATIN; CD86 ANTIGEN; CYTOKINE; DNA VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 12; LIPOSOME; PHOSPHORYL LIPID A; PLASMID DNA; QS 21;

EID: 0031775363     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (23)

References (77)
  • 5
    • 0029037299 scopus 로고
    • Use of DNAs expressing HIV-1 Env and noninfectious HIV-1 particles to raise antibody responses in mice
    • Lu S, Santoro JC, Fuller DH, Haynes JR, and Robinson HL: Use of DNAs expressing HIV-1 Env and noninfectious HIV-1 particles to raise antibody responses in mice. Virology 209: 147-154, 1995.
    • (1995) Virology , vol.209 , pp. 147-154
    • Lu, S.1    Santoro, J.C.2    Fuller, D.H.3    Haynes, J.R.4    Robinson, H.L.5
  • 9
    • 0004005413 scopus 로고
    • Vaccine Design: The subunit and adjuvant approach
    • R. T. Borchardt, ed. Plenum Press, New York
    • Powell MF, and Newman MJ. 1995. Vaccine Design: The subunit and adjuvant approach. In: Pharmaceutical Biotechnology, vol. 6. R. T. Borchardt, ed. Plenum Press, New York.
    • (1995) Pharmaceutical Biotechnology , vol.6
    • Powell, M.F.1    Newman, M.J.2
  • 11
    • 0023054680 scopus 로고
    • The ins and outs of antigen processing and presentation
    • Germain RN: The ins and outs of antigen processing and presentation. Nature 322: 687-689, 1986.
    • (1986) Nature , vol.322 , pp. 687-689
    • Germain, R.N.1
  • 13
    • 0031252387 scopus 로고    scopus 로고
    • Intranasal immunization of a DNA vaccine with interleukin 12 and granulocyte macrophage colony stimulating factor (GM-CSF) expressing plasmids in liposomes induce strong mucosal and cell-mediated immune responses against HIV-1 antigen
    • Okada E, Sasaki S, Ishii N, Aoki I, Yasuda T, Nishioka K, Fukushima J, Wahren B, and Okuda K: Intranasal immunization of a DNA vaccine with interleukin 12 and granulocyte macrophage colony stimulating factor (GM-CSF) expressing plasmids in liposomes induce strong mucosal and cell-mediated immune responses against HIV-1 antigen. J Immunol 159: 3638-3647, 1997.
    • (1997) J Immunol , vol.159 , pp. 3638-3647
    • Okada, E.1    Sasaki, S.2    Ishii, N.3    Aoki, I.4    Yasuda, T.5    Nishioka, K.6    Fukushima, J.7    Wahren, B.8    Okuda, K.9
  • 16
    • 0027213712 scopus 로고
    • Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA
    • Robinson HL, Hunt LA, and Webster RG: Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA. Vaccine 11: 957-960, 1993.
    • (1993) Vaccine , vol.11 , pp. 957-960
    • Robinson, H.L.1    Hunt, L.A.2    Webster, R.G.3
  • 18
    • 0029034177 scopus 로고
    • Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes
    • Manickan E, Rouse RJ, Yu Z, Wire WS, and Rouse BT: Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes. J Immunol 155: 259-265, 1995.
    • (1995) J Immunol , vol.155 , pp. 259-265
    • Manickan, E.1    Rouse, R.J.2    Yu, Z.3    Wire, W.S.4    Rouse, B.T.5
  • 19
    • 0029198143 scopus 로고
    • DNA-based immunization and the immune response to the hepatitis B surface antigen
    • Whalen RG: DNA-based immunization and the immune response to the hepatitis B surface antigen. Vet Res 26: 217-220, 1995.
    • (1995) Vet Res , vol.26 , pp. 217-220
    • Whalen, R.G.1
  • 20
    • 0027369829 scopus 로고
    • DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody
    • Davis HL, Michel ML, and Whalen RG: DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Hum Mol Genet 2: 1847-1851, 1993.
    • (1993) Hum Mol Genet , vol.2 , pp. 1847-1851
    • Davis, H.L.1    Michel, M.L.2    Whalen, R.G.3
  • 21
    • 0028863527 scopus 로고
    • Protection against mycoplasma infection using expression-library immunization
    • Barry MA, Lai WC, and Johnston SA: Protection against mycoplasma infection using expression-library immunization. Nature 377: 632-635, 1995.
    • (1995) Nature , vol.377 , pp. 632-635
    • Barry, M.A.1    Lai, W.C.2    Johnston, S.A.3
  • 22
    • 0029931269 scopus 로고    scopus 로고
    • DNA immunization against experimental genital herpes simplex virus infection
    • Bourne N, Stanberry LR, Bernstein DI, and Lew D: DNA immunization against experimental genital herpes simplex virus infection. J Infect Dis 173: 800-807, 1996.
    • (1996) J Infect Dis , vol.173 , pp. 800-807
    • Bourne, N.1    Stanberry, L.R.2    Bernstein, D.I.3    Lew, D.4
  • 24
    • 0028902839 scopus 로고
    • Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines
    • Xiang ZQ, and Ertl HCJ: Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2: 129-135, 1995.
    • (1995) Immunity , vol.2 , pp. 129-135
    • Xiang, Z.Q.1    Ertl, H.C.J.2
  • 25
    • 0029845387 scopus 로고    scopus 로고
    • DNA immunization induces protective immunity against B-cell lymphoma
    • Syrengelas AD, Chen TT, and Levy R: DNA immunization induces protective immunity against B-cell lymphoma. Nature Med 2: 1038-1041, 1996.
    • (1996) Nature Med , vol.2 , pp. 1038-1041
    • Syrengelas, A.D.1    Chen, T.T.2    Levy, R.3
  • 26
    • 0028077102 scopus 로고
    • Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein
    • Sedegah M, Hedstrom R, Hobart P, and Hoffman SL: Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc Natl Acad Sci USA 91: 9866-9870, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9866-9870
    • Sedegah, M.1    Hedstrom, R.2    Hobart, P.3    Hoffman, S.L.4
  • 27
    • 0028264853 scopus 로고
    • Toward a vaccine for AIDS: The emergence of immunobiology-based vaccine development
    • Cease KB, and Berzofsky JA: Toward a vaccine for AIDS: The emergence of immunobiology-based vaccine development. Ann Rev Immunol 12: 923-989, 1994.
    • (1994) Ann Rev Immunol , vol.12 , pp. 923-989
    • Cease, K.B.1    Berzofsky, J.A.2
  • 28
    • 0031038629 scopus 로고    scopus 로고
    • HIV type 1 vaccine-induced cytotoxic T cell responses: Potential role in vaccine efficacy
    • Ada GL, and McElrath MJ: HIV type 1 vaccine-induced cytotoxic T cell responses: Potential role in vaccine efficacy. AIDS Res Hum Retroviruses 13: 205-210, 1997.
    • (1997) AIDS Res Hum Retroviruses , vol.13 , pp. 205-210
    • Ada, G.L.1    McElrath, M.J.2
  • 29
    • 0025781107 scopus 로고
    • Serum antibody directed against synthetic peptides derived from HIV-1 protein sequence obtained from 26 Japanese HIV-1-infected individuals
    • Inami S, Taniguchi N, Ishibashi K, Nagao T, Aoki I, Ishii N, and Okuda K: Serum antibody directed against synthetic peptides derived from HIV-1 protein sequence obtained from 26 Japanese HIV-1-infected individuals. AIDS 5: 1140-1141, 1991.
    • (1991) AIDS , vol.5 , pp. 1140-1141
    • Inami, S.1    Taniguchi, N.2    Ishibashi, K.3    Nagao, T.4    Aoki, I.5    Ishii, N.6    Okuda, K.7
  • 30
    • 0028060351 scopus 로고
    • Evidence of three HIV-1 subtypes in subgroups of individuals in Thailand
    • Ubolyam S, Ruxrungtham K, Sirivichayakul S, Okuda K, and Phanuphak P: Evidence of three HIV-1 subtypes in subgroups of individuals in Thailand. Lancet 344: 485-486, 1994.
    • (1994) Lancet , vol.344 , pp. 485-486
    • Ubolyam, S.1    Ruxrungtham, K.2    Sirivichayakul, S.3    Okuda, K.4    Phanuphak, P.5
  • 31
    • 0028107664 scopus 로고
    • A serologic analysis and the amino acid sequence of the V3 region of human immunodeficiency virus from carriers in Bangkok
    • Okuda K, Bukawa H, Kawamoto S, Imai M, Saito T, Phanuphak P, and Hamajima K: A serologic analysis and the amino acid sequence of the V3 region of human immunodeficiency virus from carriers in Bangkok. J Infect Dis 169: 227-228, 1994.
    • (1994) J Infect Dis , vol.169 , pp. 227-228
    • Okuda, K.1    Bukawa, H.2    Kawamoto, S.3    Imai, M.4    Saito, T.5    Phanuphak, P.6    Hamajima, K.7
  • 33
    • 0028981317 scopus 로고
    • Highly divergent env sequences of HIV-1 B subtype with two novel V3 loop motifs detected in an AIDS patient in Miami, Florida
    • Xin KQ, Shapshak P, Kawamoto S, Nagano I, McCoy CB, and Okuda K: Highly divergent env sequences of HIV-1 B subtype with two novel V3 loop motifs detected in an AIDS patient in Miami, Florida. AIDS Res Hum Retroviruses 11: 1139-1141, 1995.
    • (1995) AIDS Res Hum Retroviruses , vol.11 , pp. 1139-1141
    • Xin, K.Q.1    Shapshak, P.2    Kawamoto, S.3    Nagano, I.4    McCoy, C.B.5    Okuda, K.6
  • 34
    • 0030669248 scopus 로고    scopus 로고
    • Synthetic peptide from the V3 loop consensus motif with a potent anti-HIV activity inhibits ristocetin-mediated vWF-GPIb interaction
    • Mohri H, Asakura Y, Fukushima J, Kawamoto S, Okubo T, and Okuda K: Synthetic peptide from the V3 loop consensus motif with a potent anti-HIV activity inhibits ristocetin-mediated vWF-GPIb interaction. Peptides 18: 1289-1293, 1997.
    • (1997) Peptides , vol.18 , pp. 1289-1293
    • Mohri, H.1    Asakura, Y.2    Fukushima, J.3    Kawamoto, S.4    Okubo, T.5    Okuda, K.6
  • 37
    • 0029039777 scopus 로고
    • Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate
    • Bukawa H, Sekigawa K, Hamajima K, Fukushima J, Yamada Y, Kiyono H, and Okuda K: Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate. Nature Med 1: 681-685, 1995.
    • (1995) Nature Med , vol.1 , pp. 681-685
    • Bukawa, H.1    Sekigawa, K.2    Hamajima, K.3    Fukushima, J.4    Yamada, Y.5    Kiyono, H.6    Okuda, K.7
  • 39
    • 0029861313 scopus 로고    scopus 로고
    • Induction of HIV-1 nef-specific cytotoxic T lymphocytes by nef-expressing DNA vaccine
    • Asakura Y, Hamajima K, Fukushima J, Mohri H, Okubo T, and Okuda K: Induction of HIV-1 nef-specific cytotoxic T lymphocytes by nef-expressing DNA vaccine. Am J Hematol 53: 116-117, 1996.
    • (1996) Am J Hematol , vol.53 , pp. 116-117
    • Asakura, Y.1    Hamajima, K.2    Fukushima, J.3    Mohri, H.4    Okubo, T.5    Okuda, K.6
  • 45
    • 0023809170 scopus 로고
    • Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes
    • Malim MH, Hauber J, Fenrick R, and Cullen BR: Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. Nature 335: 181-183, 1988.
    • (1988) Nature , vol.335 , pp. 181-183
    • Malim, M.H.1    Hauber, J.2    Fenrick, R.3    Cullen, B.R.4
  • 46
    • 0029047540 scopus 로고
    • Immunologic adjuvants for modern vaccine formulations
    • Vogel FR: Immunologic adjuvants for modern vaccine formulations. Ann NY Acad Sci 754: 153-160, 1995.
    • (1995) Ann NY Acad Sci , vol.754 , pp. 153-160
    • Vogel, F.R.1
  • 49
    • 0031178797 scopus 로고    scopus 로고
    • The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites
    • Iwasaki A, Torres CA, Ohashi PS, Robinson HL, and Barber BH: The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites. J Immunol 159: 11-14, 1997.
    • (1997) J Immunol , vol.159 , pp. 11-14
    • Iwasaki, A.1    Torres, C.A.2    Ohashi, P.S.3    Robinson, H.L.4    Barber, B.H.5
  • 50
    • 0029956512 scopus 로고    scopus 로고
    • Gene vaccination with naked plasmid DNA: Mechanism of CTL priming
    • Corr M, Lee DJ, Carson DA, and Tighe H: Gene vaccination with naked plasmid DNA: Mechanism of CTL priming. J Exp Med 184: 1555-1560, 1996.
    • (1996) J Exp Med , vol.184 , pp. 1555-1560
    • Corr, M.1    Lee, D.J.2    Carson, D.A.3    Tighe, H.4
  • 54
  • 55
    • 0031926264 scopus 로고    scopus 로고
    • Induction of systemic and mucosal immune responses to human immunodeficiency virus type 1 by a DNA vaccine formulated with QS-21 saponin adjuvant via intramuscular and intranasal routes
    • in press
    • Sasaki S, Sumino K, Hamajima K, Fukushima J, Ishii N, Kawamoto S, Mohri H, Kensil CR, and Okuda K: Induction of systemic and mucosal immune responses to human immunodeficiency virus type 1 by a DNA vaccine formulated with QS-21 saponin adjuvant via intramuscular and intranasal routes. J Virol 72: in press, 1998.
    • (1998) J Virol , vol.72
    • Sasaki, S.1    Sumino, K.2    Hamajima, K.3    Fukushima, J.4    Ishii, N.5    Kawamoto, S.6    Mohri, H.7    Kensil, C.R.8    Okuda, K.9
  • 56
    • 0030932988 scopus 로고    scopus 로고
    • Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization
    • Kuklin N, Daheshia M, Karem K, Manickan E, and Rouse BT: Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization. J Virol 71: 3138-3145, 1997.
    • (1997) J Virol , vol.71 , pp. 3138-3145
    • Kuklin, N.1    Daheshia, M.2    Karem, K.3    Manickan, E.4    Rouse, B.T.5
  • 59
    • 0031569963 scopus 로고    scopus 로고
    • Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines
    • Iwasaki A, Stiernholm BJN, Chan AK, Berinstein NL, and Barber BH: Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines. J Immunol 158: 4591-4601, 1997.
    • (1997) J Immunol , vol.158 , pp. 4591-4601
    • Iwasaki, A.1    Stiernholm, B.J.N.2    Chan, A.K.3    Berinstein, N.L.4    Barber, B.H.5
  • 60
    • 0031060327 scopus 로고    scopus 로고
    • Improvement of hepatitis B virus DNA vaccine by plasmids coexpressing hepatitis B surface antigen and interleukin-2
    • Chow Y-H, Huang W-L, Chi W-K, Chu Y-D, and Tao M-H: Improvement of hepatitis B virus DNA vaccine by plasmids coexpressing hepatitis B surface antigen and interleukin-2. J Virol 71: 169-178, 1997.
    • (1997) J Virol , vol.71 , pp. 169-178
    • Chow, Y.-H.1    Huang, W.-L.2    Chi, W.-K.3    Chu, Y.-D.4    Tao, M.-H.5
  • 63
    • 0030823347 scopus 로고    scopus 로고
    • HIV-1 specific cell-mediated immune responses induced by DNA vaccination are enhanced by mannan-coated liposomes and inhibited by anti-interferon (IFN)-g antibody
    • Toda S, Ishii N, Okada E, Kusakabe K-I, Arai H, Hamajima K, Gorai I, Nishioka K, and Okuda K: HIV-1 specific cell-mediated immune responses induced by DNA vaccination are enhanced by mannan-coated liposomes and inhibited by anti-interferon (IFN)-g antibody. Immunology 92: 111-117, 1997.
    • (1997) Immunology , vol.92 , pp. 111-117
    • Toda, S.1    Ishii, N.2    Okada, E.3    Kusakabe, K.-I.4    Arai, H.5    Hamajima, K.6    Gorai, I.7    Nishioka, K.8    Okuda, K.9
  • 64
    • 0029201182 scopus 로고
    • Monophosphoiyl lipid A as an adjuvant. Past experiences and new directions
    • (M. F. Powell, and M. J. Newman, eds.) New York, Plenum Press
    • Ulrich JT, and Myers KR: Monophosphoiyl lipid A as an adjuvant. Past experiences and new directions. In: Vaccine Design (M. F. Powell, and M. J. Newman, eds.) New York, Plenum Press, 1995, pp. 495-523.
    • (1995) Vaccine Design , pp. 495-523
    • Ulrich, J.T.1    Myers, K.R.2
  • 65
    • 0031906873 scopus 로고    scopus 로고
    • Comparison of intranasal and intramuscular immunization against human immunodeficiency virus type 1 with a DNA-monophosphoryl lipid A adjuvant vaccine
    • Sasaki S, Hamajima K, Fukushima J, Ihata A, N. I, Gorai I, Hirahara H, Mohri H, and Okuda K: Comparison of intranasal and intramuscular immunization against human immunodeficiency virus type 1 with a DNA-monophosphoryl lipid A adjuvant vaccine. Infect Immun 66: 823-826, 1998.
    • (1998) Infect Immun , vol.66 , pp. 823-826
    • Sasaki, S.1    Hamajima, K.2    Fukushima, J.3    Ihata, A.N.I.4    Gorai, I.5    Hirahara, H.6    Mohri, H.7    Okuda, K.8
  • 66
    • 0026033441 scopus 로고
    • Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex
    • Kensil CR, Patel U, Lennick M, and Marciani D: Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex. J Immunol 146: 431-437, 1991.
    • (1991) J Immunol , vol.146 , pp. 431-437
    • Kensil, C.R.1    Patel, U.2    Lennick, M.3    Marciani, D.4
  • 67
    • 0029176755 scopus 로고
    • Structural and immunological characterization of the vaccine adjuvant QS-21
    • (M. F. Powell, and M. J. Newman, eds.) New york, NY, Plenum Press
    • Kensil CR, Wu JY, and Soltysik S: Structural and immunological characterization of the vaccine adjuvant QS-21. In: Vaccine design: The subunit and adjuvant approach (M. F. Powell, and M. J. Newman, eds.) New york, NY, Plenum Press, 1995, pp. 525-541.
    • (1995) Vaccine Design: The Subunit and Adjuvant Approach , pp. 525-541
    • Kensil, C.R.1    Wu, J.Y.2    Soltysik, S.3
  • 68
    • 0017236348 scopus 로고
    • Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes
    • Umezawa H, Aoyagi T, Suda H, Hamada M, and Takeuchi T: Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J Antibiot 29: 97-99, 1976.
    • (1976) J Antibiot , vol.29 , pp. 97-99
    • Umezawa, H.1    Aoyagi, T.2    Suda, H.3    Hamada, M.4    Takeuchi, T.5
  • 69
    • 0025831834 scopus 로고
    • Bestatin, an aminopeptidase inhibitor with a multipharmacological function
    • Mathé G: Bestatin, an aminopeptidase inhibitor with a multipharmacological function. Biomed Pharmacother 45: 49-54, 1991.
    • (1991) Biomed Pharmacother , vol.45 , pp. 49-54
    • Mathé, G.1
  • 70
    • 0027313072 scopus 로고
    • Systemic gene expression after intravenous DNA delivery into adult mice
    • Zhu N, Liggitt D, Liu Y, and Debs R: Systemic gene expression after intravenous DNA delivery into adult mice. Science 261: 209-211, 1993.
    • (1993) Science , vol.261 , pp. 209-211
    • Zhu, N.1    Liggitt, D.2    Liu, Y.3    Debs, R.4
  • 72
    • 0031570044 scopus 로고    scopus 로고
    • Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations
    • Torres CA, Iwasaki A, Barber BH, and Robinson HL: Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations. J Immunol 158: 4529-4532, 1997.
    • (1997) J Immunol , vol.158 , pp. 4529-4532
    • Torres, C.A.1    Iwasaki, A.2    Barber, B.H.3    Robinson, H.L.4
  • 74
    • 0029021419 scopus 로고
    • IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor-deficient mice
    • Schijns VE, Haagmans BL, and Horzinek MC: IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor-deficient mice. J Immunol 155: 2525-2532, 1995.
    • (1995) J Immunol , vol.155 , pp. 2525-2532
    • Schijns, V.E.1    Haagmans, B.L.2    Horzinek, M.C.3
  • 75
    • 0029987485 scopus 로고    scopus 로고
    • Granulocytes-macrophage colony-stimulating factor: An effective adjuvant for protein and peptide-based vaccine
    • Davis ML, Bernhard H, Shiota FM, Hand SL, Gralow JR, Huseby ES, Gillis S, and Cheever MA: Granulocytes-macrophage colony-stimulating factor: an effective adjuvant for protein and peptide-based vaccine. Blood 88: 202-210, 1996.
    • (1996) Blood , vol.88 , pp. 202-210
    • Davis, M.L.1    Bernhard, H.2    Shiota, F.M.3    Hand, S.L.4    Gralow, J.R.5    Huseby, E.S.6    Gillis, S.7    Cheever, M.A.8
  • 76
    • 0027392843 scopus 로고
    • Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells
    • Townsend SE, and Allison JP: Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science 259: 368-370, 1993.
    • (1993) Science , vol.259 , pp. 368-370
    • Townsend, S.E.1    Allison, J.P.2
  • 77
    • 0028285126 scopus 로고
    • The immunobiology of muscle
    • Hohlfeld R, and Engel AG: The immunobiology of muscle. Immunol Today 15: 269-274, 1994.
    • (1994) Immunol Today , vol.15 , pp. 269-274
    • Hohlfeld, R.1    Engel, A.G.2


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