메뉴 건너뛰기




Volumn 5, Issue 2, 1999, Pages 194-203

Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS VACCINE; LIVE VACCINE;

EID: 0032905068     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/5557     Document Type: Article
Times cited : (332)

References (42)
  • 1
    • 0027908750 scopus 로고
    • Vaccines against human immunodeficiency virus - Progress and prospects
    • Letvin, N.L. Vaccines against human immunodeficiency virus - Progress and prospects. N. Engl. J. Med. 329, 1400-1405 (1993).
    • (1993) N. Engl. J. Med. , vol.329 , pp. 1400-1405
    • Letvin, N.L.1
  • 2
    • 0025066823 scopus 로고
    • Immunologic and pathologic manifestations of the infection of rhesus monkeys with simian immunodeficiency virus of macaques
    • Letvin, N.L. & King, N.W. Immunologic and pathologic manifestations of the infection of rhesus monkeys with simian immunodeficiency virus of macaques. J. Acquir. Immune Defic. Syndr. 3, 1023-1040 (1990).
    • (1990) J. Acquir. Immune Defic. Syndr. , vol.3 , pp. 1023-1040
    • Letvin, N.L.1    King, N.W.2
  • 3
    • 0025136247 scopus 로고
    • Experimental infection of timed-pregnant rhesus monkeys with simian immunodeficiency virus (SIV) during middle, and late gestation
    • Davison-Fairburn, B. et al. Experimental infection of timed-pregnant rhesus monkeys with simian immunodeficiency virus (SIV) during middle, and late gestation. J. Med. Primatol. 19,381-393 (1990).
    • (1990) J. Med. Primatol. , vol.19 , pp. 381-393
    • Davison-Fairburn, B.1
  • 4
    • 0026176901 scopus 로고
    • Maternal-fetal transmission of SIV in macaques: Disseminated adenovirus infection in an offspring with congenital SIV infection
    • Ochs, H.D. et al. Maternal-fetal transmission of SIV in macaques: Disseminated adenovirus infection in an offspring with congenital SIV infection. J. Med. Primatol. 20, 193-200 (1991).
    • (1991) J. Med. Primatol. , vol.20 , pp. 193-200
    • Ochs, H.D.1
  • 5
    • 0028862972 scopus 로고
    • Genotypic selection of simian immunodeficiency virus in macaque infants infected transplacentally
    • Amedee, A.M. et al. Genotypic selection of simian immunodeficiency virus in macaque infants infected transplacentally. J. Virol. 69, 7982-7990 (1995).
    • (1995) J. Virol. , vol.69 , pp. 7982-7990
    • Amedee, A.M.1
  • 6
    • 0027043276 scopus 로고
    • Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
    • Daniel, M.D., Kirchhoff, F., Czajak, S.C., Sehgal, P.K. & Desrosiers, R.C. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 258, 1938-1941 (1992).
    • (1992) Science , vol.258 , pp. 1938-1941
    • Daniel, M.D.1    Kirchhoff, F.2    Czajak, S.C.3    Sehgal, P.K.4    Desrosiers, R.C.5
  • 7
    • 0029031494 scopus 로고
    • Repair and evolution of nef in vivo modulates simian immunodeficiency virus virulence
    • Whatmore, A.M. et al. Repair and evolution of nef in vivo modulates simian immunodeficiency virus virulence. J. Virol. 69, 5117-5123 (1995).
    • (1995) J. Virol. , vol.69 , pp. 5117-5123
    • Whatmore, A.M.1
  • 8
    • 0029652922 scopus 로고
    • Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells
    • Almond, N. et al. Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells. Lancet 345, 1342-1344 (1995).
    • (1995) Lancet , vol.345 , pp. 1342-1344
    • Almond, N.1
  • 9
    • 0029953201 scopus 로고    scopus 로고
    • Protection from pathogenic SIVmac challenge following short-term infection with a nef-deficient attenuated virus
    • Norley, S., Beer, B., Binninger-Schninzel, D., Cosma, C. & Kurth, R. Protection from pathogenic SIVmac challenge following short-term infection with a nef-deficient attenuated virus. Virology 219, 195-205 (1996).
    • (1996) Virology , vol.219 , pp. 195-205
    • Norley, S.1    Beer, B.2    Binninger-Schninzel, D.3    Cosma, C.4    Kurth, R.5
  • 10
    • 0029951823 scopus 로고    scopus 로고
    • Vaccine protection by a triple deletion mutant of simian immunodeficiency virus
    • Wyand, M.S., Manson, K.H., Garcia-Moll, M., Montefiori, D. & Desrosiers, R.C. Vaccine protection by a triple deletion mutant of simian immunodeficiency virus. J. Virol. 70, 3724-3733 (1996).
    • (1996) J. Virol. , vol.70 , pp. 3724-3733
    • Wyand, M.S.1    Manson, K.H.2    Garcia-Moll, M.3    Montefiori, D.4    Desrosiers, R.C.5
  • 11
    • 0028914161 scopus 로고
    • Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus
    • Clements, J.E. et al. Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus. J. Virol. 69, 2737-2744 (1995).
    • (1995) J. Virol. , vol.69 , pp. 2737-2744
    • Clements, J.E.1
  • 12
    • 0025743306 scopus 로고
    • Importance of the nef gene for maintenance of high virus loads and for development of AIDS
    • rd. et al. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65, 651-662 (1991).
    • (1991) Cell , vol.65 , pp. 651-662
    • Kestler H.W. III1
  • 13
    • 0028293115 scopus 로고
    • Construction and in vitro properties of SIVmac mutants with deletions in "nonessential" genes
    • Gibbs, J.S., Regier, D. A. & Desrosiers, R.C. Construction and in vitro properties of SIVmac mutants with deletions in "nonessential" genes. AIDS Res. Hum. Retroviruses 10, 607-616 (1994).
    • (1994) AIDS Res. Hum. Retroviruses , vol.10 , pp. 607-616
    • Gibbs, J.S.1    Regier, D.A.2    Desrosiers, R.C.3
  • 14
    • 0028944667 scopus 로고
    • Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques
    • Baba, T.W. et al. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267, 1820-1825 (1995).
    • (1995) Science , vol.267 , pp. 1820-1825
    • Baba, T.W.1
  • 15
    • 0031026713 scopus 로고    scopus 로고
    • Resistance of neonatal monkeys to live attenuated vaccine strains of simian immunodeficiency virus
    • Wyand, M.S., Manson K.H., Lackner, A.A. & Desrosiers, R.C. Resistance of neonatal monkeys to live attenuated vaccine strains of simian immunodeficiency virus. Nature Med. 3, 32-36 (1997).
    • (1997) Nature Med. , vol.3 , pp. 32-36
    • Wyand, M.S.1    Manson, K.H.2    Lackner, A.A.3    Desrosiers, R.C.4
  • 16
    • 0030941649 scopus 로고    scopus 로고
    • Simultaneous defection of simian retro-virus type D serotypes 1, 2, and 3 by polymerase chain reaction
    • Liska, V., Lerche, N.W. & Ruprecht, R.M. Simultaneous defection of simian retro-virus type D serotypes 1, 2, and 3 by polymerase chain reaction. AIDS Res. Hum. Retroviruses 13, 433-437 (1997).
    • (1997) AIDS Res. Hum. Retroviruses , vol.13 , pp. 433-437
    • Liska, V.1    Lerche, N.W.2    Ruprecht, R.M.3
  • 17
    • 0031849757 scopus 로고    scopus 로고
    • Temporal analyses of virus replication, immune responses, and efficacy in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine
    • Connor, R.I. et al. Temporal analyses of virus replication, immune responses, and efficacy in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine. J. Virol. 72, 7501-7509 (1998).
    • (1998) J. Virol. , vol.72 , pp. 7501-7509
    • Connor, R.I.1
  • 18
    • 0030897105 scopus 로고    scopus 로고
    • Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1
    • Binley, J. M. et al. Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1. J. Virol. 71, 2799-2809 (1997).
    • (1997) J. Virol. , vol.71 , pp. 2799-2809
    • Binley, J.M.1
  • 19
    • 0024247071 scopus 로고
    • Simian immunodeficiency virus/Delta-induced disease in rhesus monkeys: Relation of antibody response and antigenemia
    • Zhang, J.-Y. et al. Simian immunodeficiency virus/Delta-induced disease in rhesus monkeys: Relation of antibody response and antigenemia. J. Infect. Dis. 158, 1277-1286 (1988).
    • (1988) J. Infect. Dis. , vol.158 , pp. 1277-1286
    • Zhang, J.-Y.1
  • 21
    • 0027538456 scopus 로고
    • HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease
    • Pantaleo, G. et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362, 355-358 (1993).
    • (1993) Nature , vol.362 , pp. 355-358
    • Pantaleo, G.1
  • 22
    • 0027516822 scopus 로고
    • Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS
    • Embretson, J. et al. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362, 359-362 (1993).
    • (1993) Nature , vol.362 , pp. 359-362
    • Embretson, J.1
  • 23
    • 0027936176 scopus 로고
    • Immunological and virological changes associated with decline in CD4/CD8 ratios in lymphoid organs of SIV-infected macaques
    • Rosenberg, Y.J. et al. Immunological and virological changes associated with decline in CD4/CD8 ratios in lymphoid organs of SIV-infected macaques. AIDS Res. Hum. Retroviruses 10, 863-872 (1994).
    • (1994) AIDS Res. Hum. Retroviruses , vol.10 , pp. 863-872
    • Rosenberg, Y.J.1
  • 24
    • 0026246562 scopus 로고
    • Lentivirus-induced pulmonary lesions in rhesus monkeys (Macaco mulatta) infected with simian immunodeficiency virus
    • Baskin G.B. et al. Lentivirus-induced pulmonary lesions in rhesus monkeys (Macaco mulatta) infected with simian immunodeficiency virus. Vet. Pathol. 28, 506-513 (1991).
    • (1991) Vet. Pathol. , vol.28 , pp. 506-513
    • Baskin, G.B.1
  • 25
    • 0027957797 scopus 로고
    • Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in the absence of an intact nef gene
    • Kirchoff F., Kestler H.W. III & Desrosiers, R.C. Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in the absence of an intact nef gene. J. Virol. 68, 2031-2037 (1994).
    • (1994) J. Virol. , vol.68 , pp. 2031-2037
    • Kirchoff, F.1    Kestler H.W. III2    Desrosiers, R.C.3
  • 26
    • 0028864805 scopus 로고
    • Attenuated retrovirus vaccines and AIDS
    • Baba, T.W. et al. Attenuated retrovirus vaccines and AIDS. Science 270, 1220-1222 (1995).
    • (1995) Science , vol.270 , pp. 1220-1222
    • Baba, T.W.1
  • 27
    • 0030330585 scopus 로고    scopus 로고
    • Murine and simian retrovirus models: The threshold hypothesis
    • Ruprecht, R.M., Baba, T.W., Rasmussen, R., Hu, Y. & Sharma, P. L. Murine and simian retrovirus models: The threshold hypothesis. AIDS 10 (suppl A), S33-S40 (1996).
    • (1996) AIDS , vol.10 , Issue.SUPPL. A
    • Ruprecht, R.M.1    Baba, T.W.2    Rasmussen, R.3    Hu, Y.4    Sharma, P.L.5
  • 28
    • 0025733252 scopus 로고
    • Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
    • Garcia, J.V. & Miller, D. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 350, 508-511 (1991).
    • (1991) Nature , vol.350 , pp. 508-511
    • Garcia, J.V.1    Miller, D.2
  • 29
    • 0028180868 scopus 로고
    • Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
    • Aiken, C., Konner, J., Landau, N.R., Lenburg, M.E. & Trono, D. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76, 853-864 (1994).
    • (1994) Cell , vol.76 , pp. 853-864
    • Aiken, C.1    Konner, J.2    Landau, N.R.3    Lenburg, M.E.4    Trono, D.5
  • 30
    • 0029875421 scopus 로고    scopus 로고
    • Endocytosis of major histocompatibility complex class 1 molecules is induced by the HIV-1 Nef protein
    • Schwartz, O., Marechal, V., Le Gall, S., Lemonnier F. & Heard, J.M. Endocytosis of major histocompatibility complex class 1 molecules is induced by the HIV-1 Nef protein. Nature Med. 2, 338-342 (1996).
    • (1996) Nature Med. , vol.2 , pp. 338-342
    • Schwartz, O.1    Marechal, V.2    Le Gall, S.3    Lemonnier, F.4    Heard, J.M.5
  • 31
    • 0028006247 scopus 로고
    • The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
    • Miller, M.D., Warmerdam, M.T., Gaston, I., Greene, W.C. & Feinberg, M.B. The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages. J. Exp. Med. 179, 101-113 (1994).
    • (1994) J. Exp. Med. , vol.179 , pp. 101-113
    • Miller, M.D.1    Warmerdam, M.T.2    Gaston, I.3    Greene, W.C.4    Feinberg, M.B.5
  • 32
    • 0027952787 scopus 로고
    • The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes
    • Spina, C.A., Kwoh, T.J., Chowers, M.Y., Guatelli, J.C. & Richman, D.D. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J. Exp. Med. 179, 115-123 (1994).
    • (1994) J. Exp. Med. , vol.179 , pp. 115-123
    • Spina, C.A.1    Kwoh, T.J.2    Chowers, M.Y.3    Guatelli, J.C.4    Richman, D.D.5
  • 33
    • 0027415145 scopus 로고
    • Simian immunodeficiency virus infection via amniotic fluid: A model to study fetal immunopathogenesis and prophylaxis
    • Fazely, F., Haseltine, W.A., Rodger, R.F. & Ruprecht, R.M. Simian immunodeficiency virus infection via amniotic fluid: A model to study fetal immunopathogenesis and prophylaxis. J. Acq. Immune Defic. Syndr. 6, 107-114 (1993).
    • (1993) J. Acq. Immune Defic. Syndr. , vol.6 , pp. 107-114
    • Fazely, F.1    Haseltine, W.A.2    Rodger, R.F.3    Ruprecht, R.M.4
  • 34
    • 0028295063 scopus 로고
    • Safety issues facing development of a live-attenuated, multiply deleted HIV-1 vaccine
    • Desrosiers, R.C. Safety issues facing development of a live-attenuated, multiply deleted HIV-1 vaccine. AIDS Res. Hum. Retroviruses 10, 331-332 (1994).
    • (1994) AIDS Res. Hum. Retroviruses , vol.10 , pp. 331-332
    • Desrosiers, R.C.1
  • 35
    • 0021961951 scopus 로고
    • Oral poliovirus vaccine: History of its development and use and current challenge to eliminate poliomyelitis from the world
    • Sabin, A. B. Oral poliovirus vaccine: History of its development and use and current challenge to eliminate poliomyelitis from the world. J. Infect. Dis. 151, 420-436 (1985).
    • (1985) J. Infect. Dis. , vol.151 , pp. 420-436
    • Sabin, A.B.1
  • 36
    • 0030763089 scopus 로고    scopus 로고
    • Detection of simian T cell leukemia virus type I infection in seronegative macaques
    • Liska, V., Fultz, P.N., Su, L. & Ruprecht, R.M. Detection of simian T cell leukemia virus type I infection in seronegative macaques. AIDS Res. Hum. Retrovirusrs 13, 1147-1153 (1997).
    • (1997) AIDS Res. Hum. Retrovirusrs , vol.13 , pp. 1147-1153
    • Liska, V.1    Fultz, P.N.2    Su, L.3    Ruprecht, R.M.4
  • 37
    • 0028176456 scopus 로고
    • Mucosal infection of neonatal rhesus monkeys with cell-free SIV
    • Baba, T.W. et al. Mucosal infection of neonatal rhesus monkeys with cell-free SIV. AIDS Res. Hum. Retroviruses 10, 351-357 (1994).
    • (1994) AIDS Res. Hum. Retroviruses , vol.10 , pp. 351-357
    • Baba, T.W.1
  • 38
    • 0029896211 scopus 로고    scopus 로고
    • Infection and AIDS in adult macaques after nontraumatic oral exposure to cell-free SIV
    • Baba T.W. et al. Infection and AIDS in adult macaques after nontraumatic oral exposure to cell-free SIV. Science 272, 1486-1489 (1996).
    • (1996) Science , vol.272 , pp. 1486-1489
    • Baba, T.W.1
  • 39
    • 0030955396 scopus 로고    scopus 로고
    • Effects of (R)-9-(2-phosphonylmethoxypropyl) adenine monotherapy on chronic SIV infection in macaques
    • Tsai, C.-C. et al. Effects of (R)-9-(2-phosphonylmethoxypropyl) adenine monotherapy on chronic SIV infection in macaques. AIDS Res. Hum. Retroviruses 13, 707-712 (1997).
    • (1997) AIDS Res. Hum. Retroviruses , vol.13 , pp. 707-712
    • Tsai, C.-C.1
  • 40
    • 0003747871 scopus 로고
    • (eds. Coligan, J., Kruisbeek, A., Margulies, D., Shevach, E., & Stober, W.)Wiley, New York
    • Fox, C.H. & Cottler-Fox, M.H. in Current Protocols in Immunology, (eds. Coligan, J., Kruisbeek, A., Margulies, D., Shevach, E., & Stober, W.)(Wiley, New York, 1993).
    • (1993) Current Protocols in Immunology
    • Fox, C.H.1    Cottler-Fox, M.H.2
  • 41
    • 0345360806 scopus 로고    scopus 로고
    • Progesterone implants enhance SIV vaginal transmission and early virus load
    • Marx, P.A. et al. Progesterone implants enhance SIV vaginal transmission and early virus load. Nature Med. 2, 1084-1089 (1996).
    • (1996) Nature Med. , vol.2 , pp. 1084-1089
    • Marx, P.A.1
  • 42
    • 0027122957 scopus 로고
    • 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults
    • numder RR-17
    • Centers for Disease Control. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Morbid. Mortal. Weekly Rep. 41 (numder RR-17), 1-19 (1992).
    • (1992) Morbid. Mortal. Weekly Rep. , vol.41 , pp. 1-19


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.