Successful nucleic acid based immunization of newborn chimpanzees against hepatitis B virus

Vaccine

Volumn 15, Issue 8, 1997, Pages 916-919

  Prince, Alfred M ^a   Whalen, Robert ^b   Brotman, Betsy ^c  

^a Lindsley F Kimball Res Inst N   (United States)

^b CNRS   (France)

^c Vilab II   (South Africa)

Author keywords

Chimpanzees; Hepatitis B virus; Nucleic acid based vaccine

Indexed keywords

DNA VACCINE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; CHIMPANZEE; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; HEPATITIS B; HEPATITIS B VIRUS; IMMUNOMODULATION; INTRAMUSCULAR DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; DNA, VIRAL; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VACCINES; PAN TROGLODYTES; VACCINES, DNA;

EID: 0030752483     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(96)00248-4     Document Type: Conference Paper

References (4)

1. Michel, M.-L., Davis, H.L., Schleet, M., Mancini, M., Tiollais, P. and Whalen, R.H. DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans. PNAS, USA 1995, 92, 5307-5311
2. Davis, H.L., Michel, M.-L. and Whalen, R.G. DNA based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Hum. Molec. Genetics 1993, 2, 1847-1851
3. Davis, H.L., Michel, M.-L., Mancini, M., Schleef, M. and Whalen, R.G. Direct gene transfer in skeletal muscle: plasmid DNA based immunization against the hepatitis B surface antigen. Vaccine 1994, 12, 1503-1510
4. Davis, H.L., Michel, M.-L. and Whalen, R.G. DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Hum. Molec. Genet. 1993, 2, 1847-1851