DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice

Journal of Immunology

Volumn 156, Issue 10, 1996, Pages 3687-3695

  Kuhöber, Andreas ^a   Pudollek, Hans Peter ^a   Reifenberg, Kurt ^b   Chisari, Francis V ^c   Schlicht, Hans Jürgen ^a   Reimann, Jörg ^a,b   Schirmbeck, Reinhold ^a  

^a Inst Med Microbiol and Immunol   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; HEPATITIS B CORE ANTIGEN; HEPATITIS B VACCINE; VIRUS DNA;

ACTIVE IMMUNIZATION; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CYTOMEGALOVIRUS; CYTOTOXIC T LYMPHOCYTE; HEPATITIS B; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; DNA, VIRAL; EPITOPES; FEMALE; H-2 ANTIGENS; HEPATITIS B ANTIBODIES; HEPATITIS B CORE ANTIGENS; HEPATITIS B VACCINES; HEPATITIS B VIRUS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PLASMIDS; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION; VACCINES, SYNTHETIC;

EID: 0029913027     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Chisari, F. V., and C Ferran. 1995. Hepatitis B virus immunopathogenesis. Annu. Rev Immunol 13.29.
2. Ferrari, C., A. Bertoletti, A. Penna, A. Cavalli, A Valli, G. Missale, M. Pilli, P. Fowler, T. Giuberti, F. V. Chisari, et al. 1991. Identification of immunodominant T cell epitopes of the hepatitis B virus nueleocapsid antigen. J Clin. Invest. 88:214.
3. Penna, A , F. V. Chisari, A Bertoletti, G. Missale, P. Fowler, T. Giuberti, F. Fiaccadori, and C. Ferrari. 1991. Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B viras nueleocapsid antigen. J. Exp. Med. 174:1565.
4. Bertoletti, A., C. Ferrari, F. Fiaccadori, A. Penna, R. Margolskee, H. J. Schlicht, P. Fowler, S. Guilhot, and F V. Chisari. 1991. HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen. Proc. Natl. Acad. Sci USA 88:10445.
5. Penna, A , P. Fowler, A. Bertoletti, S. Guilhot, B. Moss, R. F. Margolskee, A. Cavalli, A. Valli, F. Fiaccadori, and F. V Chisari. 1992. Hepatitis B virus (HBV)-specific cytotoxic T-cell (CTL) response in humans: characterization of HLA class II-restricted CTLs that recognize endogenously synthesized HBV envelope antigens. J. Virol. 66.1193.
6. Bertoletti, A., F V. Chisari, A. Penna, S. Guilhot, L. Galati, G. Missale, P. Fowler, H J. Schlicht, A. Vitiello, and R. C. Chesnut. 1993. Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nueleocapsid protein J. Virol. 67:2376.
7. Missale, G., A. Redeker, J. Person, P. Fowler, S Guilhot, H J. Schlicht, C. Ferrari, and F. V. Chisari. 1993. HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nueleocapsid epitope during acute viral hepatitis. J. Exp. Med. 177:751.
8. Nayersina, R., P. Fowler, S. Guilhot, G. Missale, A. Cerny, H.-J. Schlicht, A Vitiello, R. Chesnut, J. L. Person, A. G. Redeker, and F. V. Chisari 1993 HLA-A2-restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection. J. Immunol. 150:4659
9. Rehermann, B., P Fowler, J. Sidney, J. Person, A. Redeker, M. Brown, B. Moss, A. Sette, and F. V. Chisari. 1995. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J. Exp. Med. 181 1047.
10. Standring, D. N. 1995. The molecular biology of the hepatitis B virus core protein In Molecular Biology of the Hepatitis B Virus. A. McLachlan, ed. CRC Press, Boca Raton, FL, p. 145
11. Milich, D R., A. McLachlan, A. K. Raney, R. A. Houghten, G. B. Thorton, T. Maruyama, J. L. Hughes, and J. E. Jones. 1991 Autoantibody production in hepatitis B antigen transgenic mice elicited with a self T-cell peptide and inhibited with nonself peptides. Proc. Natl. Acad. Sci. USA 88:4348.
12. Milich, D. R 1991 Use of recombinant HBV proteins in immunological studies. In Molecular Biology of the Hepatitis B Virus. A. McLachlan, ed. CRC Press, Boca Raton, FL, p. 283.
13. Milich, D. R , D. L. Peterson, F. Schodel, J E. Jones, and J. L. Hughes. 1995. Preferential recognition of hepatitis B nueleocapsid antigens by Th1 or Th2 cells is epitope and major histocompatibility complex dependent. J. Virol 69:2776.
14. Vitiello, A , G. Ishioka, H. M. Grey, R. Rose, P. Farness, R. LaFond, L. Yuan, F. V. Chisari, J. Furze, and R. Bartholomeuz. 1995. Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I Induction ut a primary cytotoxic T lymphocyte response in humans. J. Clin. Invest. 95:341
15. + cytotoxic T lymphocytes in mice. Eur J. Immunol. 22:759
16. Schirmbeck, R., J. Zerrahn, A Kuhlober, W. Deppert, and J. Reimann 1993. Immunization of mice with the N-terminal (1-272) fragment of simian virus 40 large T-antigen (without adjuvants) specifically primes cytotoxic T lymphocytes. Eur. J. Immunol. 23:1528.
17. Schirmbeck, R., W. Böhm, and J. Reimann. 1994. Injection of detergent-denatured ovalbumin primes murine class I-restricted cytotoxic T cells in vivo. Eur. J. Immunol. 24:2068.
18. Schirmbeck, R., K Melber, T. Mertens, and J Reimann. 1994. Selective stimulation of murine cytotoxic T cell and antibody responses by particulate or monomeric hepatitis B virus surface (S) antigen. Eur. J Immunol. 24:1088.
19. Schirmbeck, R , K. Melber, T. Mertens, and J. Reimann 1994. Antibody and cytotoxic T-cell responses to soluble hepatitis B virus (HBV) S antigen in mice: implication for the pathogenesis of HBV-induced hepatitis. J Virol 68:1418.
20. + cytotoxtc T lymphocyte responses in vivo J. Immunol. 152:1110.
21. Schirmbeck, R., L Deml, K. Melber, H. Wolf, R. Wagner, and J. Reimann 1995. Priming of class I-restricted cytotoxic T lymphocytes by vaccination with recombinant protein antigens. Vaccine 13:857
22. Tang, D. C., M. DeVit, and S. A. Johnston. 1992. Genetic immunization is a simple method for eliciting an immune response. Nature 356:152.
23. Raz, E., D. A. Carson, S. E. Parker, T. B. Parr, A. M. Abai, G. Aichinger, S. H. Gromkowski, M. Singh, D. Lew, and M. A. Yankauckas. 1994. Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. Natl. Acad. Sci. USA 91.9519
24. Jiao, S., P. Williams, R. K. Berg, B. A. Hodgeman, L. M. Liu, G. Repetto, and J. A. Wolff 1992. Direct gene transfer into nonhuman primate myofibers in vivo. Hum. Gene Ther. 3:21
25. Wolff, J. A , J. J. Ludtke, G. Acsadi, P. Williams, and A. Jani. 1992. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum. Mol. Genet. 1:363.
26. Davis, H L., B. A Demeneix, B. Quantin, J. Coulombe, and R. G Whalen. 1993. Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle. Hum Gene Ther. 4:733.
27. Davis, H. L., M. L. Michel, and R. G. Whalen. 1993. DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Hum. Mol. Genet. 2:1847
28. Davis, H. L., R. G. Whalen, and B. A. Demeneix. 1993. Direct gene transfer into skeletal muscle in vivo: factors affecting efficiency of transfer and stability of expression. Hum. Gene Ther. 4:151
29. Montgomery, D L., J W. Shiver, K. R. Leander, H. C. Perry, A. Friedman, D. Martinez, J. B. Ulmer, J J. Donnelly, and M. A. Liu. 1993. Heterologous and homologous protection against influenza A by DNA vaccination: optimization of DNA vectors. DNA Cell Biol. 12:777.
30. Ulmer, J. B., J J. Donnelly, S. E. Parker, G. H. Rhodes, P L. Felgner, V. J. Dwarki, S. H. Gromkowski, R. R. Deck, C. M DeWitt, and A. Friedman. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745
31. Wang, B., K. E. Ugen, V. Srikantan, M G. Agadjanyan, K. Dang, Y. Refaeli, A. I. Sato, J. Boyer, W. V. Williams, and D. B. Weiner. 1993. Gene inoculation generates immune responses against human immunodeficiency virus type 1 Proc. Natl. Acad. Sci USA 90:4156.
32. Nabel, E G., G. Plautz, and G. J. Nabel. 1992. Transduction of a foreign histocompatibility gene into the arterial wall induces vasculitis. Proc. Natl Acad. Sci. USA 89:5157.
33. Sedegah, M , R. Hedstrom, P. Hobart, and S. L. Hoffman. 1994. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc. Natl Acad. Sci USA 91:9866.
34. Xiang, Z. Q., S. Spitalnik, M. Tran, W. H. Wunner, J. Cheng, and H. C. J. Ertl. 1994. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology 199:132.
35. Lagging, L. M., K Meyer, D. Hoft, M. Houghton, R. B. Belshe, and R. Ray. 1995. Immune response to plasmid DNA encoding the hepatitis C virus core protein. J. Virol 69:5859.
36. Fynan, E F., R. G. Webster, D. H. Fuller, J. R. Haynes, J. C Santoro, and H. L. Robinson. 1993. DNA Vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc. Natl. Acad. Sci. USA 90:11478
37. Ulmer, J. B., R. R. Deck, C M. DeWitt, A. Friedman, J. J Donnelly, and M. A. Liu. 1994. Protective immunity by intramuscular injection of low doses of influenza virus DNA vaccines. Vaccine 12.1541.
38. Donnelly, J. J., A. Friedman, D. Martinez, D. L. Montgomery, J. W. Shiver, S. L. Motzel, J. B. Ulmer, and M. A. Liu. 1995. Preclinical efficacy of a prototype DNA vaccine: enhanced protection against antigenic drift in influenza virus Nature Med. 1:583.
39. Xiang, Z. Q., and H C. J Ertl. 1995. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2.129.
40. Martins, L P., L. L. Lau, M. S Asano, and R. Ahmed. 1995. DNA vaccination against persistent viral infection. J. Virol. 69:2574.
41. Yokoyama, M., J Zhang, and J. L. Whitton. 1995. DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection. J. Virol. 69 2684.
42. Xu, D., and F. Y. Liew. 1994. Genetic vaccination against leishmaniasis. Vaccine 12.1534.
43. Xu, D., and F. Y. Liew. 1995. Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major. Immunology 84:173.
44. Davis, H. L., R. Schirmbeck, J Reimann, and R. G Whalen. 1995. DNA-mediated immunization in mice induces a potent MHC class I-restricted cytotoxic T lymphocyte response to Hepatitis B virus surface antigen. Hum. Gene Ther. 6:1447.
45. Schirmbeck, R , W. Böhm, K. Ando, F. V. Chisari, and J. Reimann. 1995. Nucleic acid vaccination primes hepatitis B surface antigen-specific cytotoxic T lymphocytes in nonresponder mice. J Virol. 69:5929.
46. Nassal, M. 1988. Total chemical synthesis of a gene for hepatitis B virus core protein and its functional characterization. Gene 6:279.
47. Artlelt, P., C. Morelle, M. Ausmeier, M. Fitzek, and J. Hauser. 1988. Vectors for efficient expression in mammalian fibroblastoid, myeloid and lymphoid cells via transfecrion or infection. Gene 68:213.
48. Ljunggren, H.-G., and K Karre. 1985. Host resistance directed selectively against H-2 deficient lymphoma variants: analysis of the mechanism. J. Exp. Med. 162: 1745.
49. Karasuyama, H., and F. Melchers. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 and 5, using modified cDNA expression vectors. Eur. J Immunol 18:97
50. Rammensee, H. G., T. Friede, and S. Stevanoviic. 1995. MHC ligands and peptide motifs: first listing. Immunogenetics 41:178
51. Chisari, F. V., K. Klopchin, T. Moriyama, C. Pasquinelli, H. A. Dunsdorf, S. Sell, C A. Pinkert, R L. Brinster, and R D. Palmiter. 1989. Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59:1145.
52. Moriyama, T., S. Guilhot, K. Klopchin, B. Moss, C. A. Pinkert, R. D. Palmiter, R L. Brinster, O. Kanagawa, and F. V. Chisari. 1990. Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science 248:361.
53. Chisari, F. V. 1992. Hepatitis B virus biology and pathogenesis Mol. Genet. Med. 2:67.
54. Ando, K., T. Monyama, L G. Guidotti, S Wirth, R. D. Schreiber, H.-J. Schlicht, S.-N. Huang, and F. V. Chisari. 1993. Mechanisms of class I restricted immunopathology a transgenic mouse model of fulminant hepatitis J Exp. Med. 178: 1541.
55. Ando, K., L. G. Guidotti, A. Cerny, T. Ishikawa, and F V. Chisari. 1994. Access to antigen restricts cytotoxic T lymphocyte function in vivo. J. Immunol. 152: 3245.
56. Ando, K , L G. Guidotti, A. Cerny, T. Ishikawa, and F. V Chisari. 1994. CTL access to tissue antigen is restricted in vivo. J. Immunol. 153:482.
57. Ando, K., L. G Guidotti, S. Wirth, T. Ishikawa, G. Missale, T Moriyama, R. D. Schreiber, H. J. Schlicht, S N. Huang, and F. V. Chisari. 1994 Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo. J. Immunol. 152:3245.
58. Guidotti, L. G., K Ando, M V. Hobbs, T. Ishikawa, L. Runkel, R. D Schreiber, and F. V. Chisari. 1994. Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc. Natl. Acad. Sci. USA 91 3764.
59. Huang, S N , and F. V. Chisari. 1995. Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice. Hepatology 21:620
60. + cytolytic T cell response by chimeric HIV-1 virus-like particles in vivo: implications on HIV vaccine development. Behring Inst Mitt. 95:23.
61. Deres, K., H. Schild, K.-H. Wiesmüller, G. Jung, and H G Rammensee. 1989. In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine Nature 342:561.
62. Schild, H , M. Norda, K. Deres, K. Falk, O. Rötzschke, K.-H. Wiesmuller, G. Jung, and H. G. Rammensee 1991. Fine specificity of cytotoxic T lymphocytes primed in vivo either with virus or synthetic lipopeptide vaccine or primed in vitro with peptide. J. Exp. Med. 174:1665.
63. Schild, H., K. Deres, K.-H. Wiesmüller, G. Jung, and H G Rammensee. 1991. Efficiency of peptides and lipopeptides for in vivo priming of virus-specific cytotoxic T cells. Eur. J. Immunol. 21:2649.
64. Martinon, F., H. Gras-Masse, C. Boutillon, F. Chirat, B. Deprez, J.-G. Guillet, E Gomard, A. Tartar, and J.-P Levy. 1992. Immunization of mice with lipopeptides bypasses the prerequisite for adjuvant: immune response of BALB/c mice to human immunodeficiency virus envelope glycoprotein. J. Immunol. 149:3416
65. Larsson, M., K. Lövgren, and B. Morein. 1993. Immunopotentiation of synthetic oligopeptides by chemical conjugation to iscoms J. Immunol Methods 162:257.
66. Nardelli, B., and J. P. Tam. 1993. Cellular immune responses induced by in vivo priming with a lipid-conjugated multimeric antigen peptide. Immunology 79:355.
67. Böhm, W., R. Schirmbeck, A Elbe, K. Melber, D Diminsky, G. Kraal, N. Van Rooijen, Y. Barenholz, and J. Reimann. 1995. Exogenous hepatitis B surface antigen particles processed by dendritic cells or macrophages prime murine MHC class I-restricted cytotoxic T lymphocytes in vivo. J Immunol. 155: 3313
68. Schirmbeck, R., K. Melber, and J. Reimann. 1995. Hepatitis B virus surface particles are processed in a novel endosomal pathway for MHC class I-restricted epitope presentation. Eur. J. Immunol. 25:1063