Increased DNA vaccine delivery and immunogenicity by electroporation in vivo

Journal of Immunology

Volumn 164, Issue 9, 2000, Pages 4635-4640

  Widera, Georg ^a   Austin, Melissa ^a   Rabussay, Dietmar ^a   Goldbeck, Cheryl ^b   Barnett, Susan W ^b   Chen, Minchao ^b   Leung, Louisa ^b   Otten, Gillis R ^b   Thudium, Kent ^b   Selby, Mark J ^b   Ulmer, Jeffrey B ^b  

^a Inovio Biomedical Corporation   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; HEPATITIS B VACCINE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; DRUG DELIVERY SYSTEM; DRUG POTENCY; ELECTROPORATION; FEMALE; IMMUNE RESPONSE; IMMUNOGENICITY; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINATION;

EID: 18144446323     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.9.4635     Document Type: Article

References (29)

1. Donnelly, J., J. Ulmer, J. Shiver, and M. Liu. 1997. DNA Vaccines. Annu. Rev. Immunol. 15:617.
2. Calarola, S., G. Bratt, S. Nordlund, J, Hinkula, A. C. Leandersson, E. Sandstrom, and B. Wahren. 1998. Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients. Lancet 351:1320.
3. MacGregor, R., J. Boyer, K. Ugen, K. Lacy, S. Gluckman, M. Bagarazzi, M. Chattergoon, Y. Baine, T. Higgins, R. Ciccarelli, et al. 1998. First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type I infection: safety and host response. J. Infect. Dis. 178:92.
4. Wang R., D. L. Doolan, T. P. Le, R. C. Hedstrom, K. M. Coonan, Y, Charoenvit, T. R. Jones, P. Hobart, M. Margalith, J. Ng. et al. 1998. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science 282:476.
5. Mathiesen, I. 1999. Electropermeabilization of skeletal muscle enhances gene transfer in vivo. Gene Ther. 6:508.
6. Rizzulo, G., M. Cappelletti, D. Maione, R. Savino, D. Lazzaro, P. Costa, I. Mathiesen, R. Cortese, G. Ciliberto, R. Laufer, et al. 1999. Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation. Proc. Natl. Acad. Sci. USA 96:6417.
7. Gato, T., T. Nishi, T. Tamura, S. B. Dev, H. Takeshima, M. Kochi, J. Kuratsu, T. Sakata, G. A. Hofmann, and Y. Ushio. 2000. Highly efficient electro-gene therapy of solid tumor using an expression plasmid for the HSV-TK gene. Proc. Natl. Acad. Sci. USA 97:354.
8. Titomirov, A., S. Sukharev, and E. Kistanova. 1991. In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA. Biochim. Biophys. Acta 1088:131.
9. Nomura, M., Y. Nakata, T. Inoue, A, Uzawa, S. Itamura, K. Nerome, M. Akashi, and G. Suzuki. 1996. In vivo induction of cytotoxic T lymphocytes specific for a single epitope introduced into an unrelated molecule. J. Immunol. Methods 193:41.
10. Heller, R., M. Jaroszeski, A. Atkin, D. Moradpour, R. Gilbert, J. Wands, and C. Nicolau. 1996. In vivo gene electroinjection and expression in rat liver. FEBS Lett. 389:225.
11. Suzuki, T., B.-C. Shin, K. Fujikura, T. Matsuzaki, and K. Takata. 1998. Direct gene transfer into rat liver cells by in vivo electroporation. FEBS Lett. 425:436.
12. Nishi, T., K. Yoshizato, S. Yamashiro, H. Takeshima, K. Sato, K. Hamada, I. Kitamura, T. Yoshimura, H. Saya, J. Kuratsu, and Y. Ushio. 1996. High-efficiency in vivo gene transfer using intraarterial plasmid DNA injection following in vivo electroporation. Cancer Res. 56:1050.
13. Nishi, T., S. Dev, K. Yoshizato, J. Kuratsu, and Y. Ushio. 1997. Treatment of cancer using pulsed electric field in combination with chemotherapeutic agents or genes. Hum. Cell 10:81.
14. Rols, M. P., C. Delteil, M. Golzio, P. Dumond, S. Cros, and J. Teissie. 1998. In vivo electrically mediated protein and gene transfer in murine melanoma. Nature Biotechnol. 16:168.
15. Aihara, H., and J. Miyazaki. 1998. Gene transfer into muscle by electroporation in vivo. Nat. Biotechnol. 16:867.
16. Mizushima, S., and S. Nagata. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5322.
17. Moriarty, A. M., B. H. Hoyer, J. W. Shih, J. L. Gerin, and D. H. Hamer. 1981. Expression of the hepatitis B virus surface antigen in cell culture by using a simian virus 40 vector. Proc. Natl. Acad. Sci. USA 78:2606.
18. Chapman B. S., R. M. Thayer, K. A. Vincent, and N. L. Haigwood. 1991. Effect of intron A from human cytomegalovirus (Towne) immediate early gene on heterologous expression in mammalian cells. Nucleic Acids Res. 19:3979.
19. Zur Megede J., B. Doe, M. Schaefer, C. E. Greer, M. J. Selby, M.-C. Chen, G. R. Otten, and S. W. Barnett. 2000. Increased expression and immunogenicity of sequence-modified human immunodeficiency virus type 1 gag gene. J. Virol. 74:2628.
20. Hofmann, G. A., S. B. Dev, and G. S. Nanda. 1996. Electrochemotherapy: transition from laboratory to the clinic. IEEE Eng. Med. Biol. 15:124.
21. Doe, B., and C. M. Walker. 1996. HIV-1 p24 Gag-specific cytotoxic T-lymphocyte responses in mice. AIDS 10:793.
22. Mir, L., M. Bureau, J. Gehl, R. Rangara, D. Rouy, J.-M. Caillaud, P. Delaere, D. Branellec, B. Schwartz, and D. Scherman. 1999. High-efficiency gene transfer into skeletal muscle mediated by electric pulses. Proc. Natl. Acad. Sci. USA 96:4262.
23. Davis, H. L, M.-L. Michel, and R. G. Whalen. 1993. DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Hum. Mol. Genet. 2:1847.
24. Mir, L., M. Bureau, R. Rangara, B. Schwartz, and D. Scherman. 1998. Longterm, high level in vivo gene expression after electric pulse-mediated gene transfer into skeletal muscle. C. R. Acad. Sci. Ser. III 321:893.
25. Chang, D. C., and Reese. T. S. 1990. Changes in membrane structure induced by electroporation as revealed by rapid-freezing electron microscopy, Biophys. J. 58:1.
26. Huang, A. Y., P. Golumbek, M. Ahmadzadeh, E. Jaffee, D. Pardoll, and H. Levitsky. 1994. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264:961.
27. Timares, L., A. Takashima, and S. A. Johnston. 1998. Quantitative analysis of the immunopotency of genetically transfected dendritic cells. Proc. Natl. Acad. Sci. USA 95:13147.
28. Ulmer, J. B., R. R. Deck, C. M. DeWitt, J. J. Donnelly, and M. A. Liu. 1996. Generation of MHC class I-restricted cytotoxic T lymphocytes by expression of a viral protein in muscle cells: antigen presentation by non-muscle cells. Immunology 89:59.
29. Loirat, D., Z. Li, M. Mancini, P. Tiollas, D. Paulin, and M.-L. Michel. 1999. Muscle-specific expression of hepatitis B surface antigen: no effect on DNA-raised immune responses. Virology 260:74.