Improving protective immunity induced by DNA-based immunization: Priming with antigen and GM-CSF-encoding plasmid DNA and boosting with antigen- expressing recombinant poxvirus

Journal of Immunology

Volumn 164, Issue 11, 2000, Pages 5905-5912

  Sedegah, Martha ^a,b   Weiss, Walter ^a   Sacci Jr , John B ^a,b   Charoenvit, Yupin ^a   Hedstrom, Richard ^a   Gowda, Kalpana ^a   Majam, Victoria F ^a   Tine, John ^c   Kumar, Sanjai ^a,d   Hobart, Peter ^e   Hoffman, Stephen L ^a  

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c Virogenetics Corporation   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e VICAL INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLASMID DNA; PROTEIN PYCSP; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; SPOROZOITE VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; FEMALE; IMMUNIZATION; MOUSE; NONHUMAN; PARASITE IMMUNITY; PLASMODIUM YOELII; POXVIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 18844463657     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.11.5905     Document Type: Article

References (31)

1. Sedegah, M., R. Hedstrom, P. Hobart, and S. L. Hoffman. 1994. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc. Natl. Acad. Sci. USA 91:9866.
2. Doolan, D. L., M. Sedegah, R. C. Hedstrom, P. Hobart, Y. Charoenvit, and S. L. Hoffman. 1996. Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ T cell-, interferon-, and nitric oxide-dependent immunity. J. Exp. Med. 183:1739.
3. Weiss, W. R., K. J. Ishii, R. C. Hedstrom, M. Sedegah, K. Barnhart, D. Klinman and S. L. Hoffman. 1998. A plasmid encoding murine granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine. J. Immunol. 161: 2325.
4. Hoffman, S. L., E. D. Franke, M. R. Hollingdale, and P. Druilhe. 1996. In Malaria Vaccine Development: A Multi-Immune Response Approach. S. L. Hoffman, ed. Chap 3. American Society for Microbiology, Washington, DC.
5. Miller, L., and S. L. Hoffman. 1998. Research toward vaccines against malaria. Nat. Med. (Suppl.) 4:520.
6. Sedegah, M., T. R. Jones, M. Kaur, R. Hedstrom, P. Hobart, J. A. Tine, and S. L. Hoffman. 1998. Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine. Proc. Natl. Acad. Sci. USA 95:7648.
7. + T-cell-mediated protective immunity against malaria. Proc. Natl. Acad. Sci. USA 90:5214.
8. Schneider, J., S. C. Gilbert, T. J. Blanchard, T. Hanke, K. J. Robson, C. M. Hannan, M. Becker, R. Sinden, G. L. Smith, and A. V. S. Hill. 1998. Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nat. Med. 4:397.
9. Plebanski, M., S. C. Gilbert, J. Schneider, C. M. Hannan, G. Layton, T. J. Blanchard, M. Becker, G. L. Smith, G. Butcher, R. Sinden, et al. 1998. Protection from Plasmodium berghei infection by priming and boosting T cells to a single class 1-restricted epitope with recombinant carriers suitable for human use. Eur. J. Immunol. 28:4345.
10. Leong, K. H., A. J. Ramsey, I. A. Ramshaw, M. J. Morin, H. L. Robinson, and D. B. Boyle. 1995. Generation of enhanced immune responses by consecutive immunization with DNA and recombinant fowl pox vectors. In Vaccines 95. R. M. Chanock, F. Brown, H. S. Ginsberg, and E. Norrby, eds. Cold Spring Harbor Laboratory, pp. 327-331.
11. Rothel, J. S., D. B. Boyle, G. W. Both, A. D. Pye, J. G. Waterkeyn, P. R. Wood, and M. W. Lightowlers. 1997. Sequential nucleic acid and recombinant adenovirus vaccination induces host-protective immune responses against Taenia ovis infection in sheep. Parasite Immunol. 19:221.
12. Richmond, J. F., F. Mustafa, S. Lu, J. C. Santoro, J. Weng, M. O'Connell, E. M. Fenyo, J. L. Hurwitz, D. C. Montefiori, and H. L. Robinson. 1997. Screening of HIV-1 Env glycoproteins for the ability to raise neutralizing antibody using DNA immunization and recombinant vaccinia virus boosting. Virology 230:265.
13. Irvine, K. R., R. S. Chamberlain, E. P. Shulman, D. R. Surman, S. A. Rosenberg, and N. P. Restifo. 1997. Enhancing efficacy of recombinant anticancer vaccines with prime/boost regimens that use two different vectors. J. Natl. Cancer Inst. 89:1595.
14. Lieschke, G. J., and A. W. Burgess. 1992. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor (2). N. Engl. J. Med. 327:99.
15. Kuzrock, R., M. Talpaz, and J. U. Gutterman. 1992. Very low doses of GM-CSF administered alone or with erythropoietin in aplastic anemia. Am. J. Med. 933:41.
16. Estey, E. H., R. Kurzrock, M. Talpaz, K. B. McCredie, S. O'Brien, H. M. Kanrarjian, M. J. J. Keating, A. B. Deisseroth, and J. U. Gutterman. 1991. Effects of low doses of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with myelodysplastic syndromes. Br. J. Haematol. 77:291.
17. Simons, J. W., E. M. Jaffee, C. E. Weber, H. I. Levitsky, W. G. Nelson, M. A. Carducci, A. J. Lazenby, L. K. Cohen, C. C. Finn, S. M. Clift, et al. Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer. Cancer Rex. 57:15337.
18. Charoenvit, Y., S. Mellouk, C. Cole, R. Bechara, M. Leef, M. Sedegah, L. F. Yuan, F. A. Robey, R. L. Beaudoin, and S. L. Hoffman. 1991. Monoclonal but not polyclonal antibodies protect against Plasmodium yoelii sporozoites. J. Immunol. 146:1020.
19. + T cells using an ELISPOT assay. J. Immunol. 153:4636.
20. Hoffman, S. L., D. Isenbarger, G. Long, M. Sedegah, A. Szarfman, L. Waters, M. R. Hollingdale, P. H. Van der Meide, D. S. Finbloom, and W. R. Ballou. 1989. Sporozoite vaccine induces genetically restricted T-cell elimination of malaria from hepatocytes. Science 244:1078.
21. Charoenvit, Y., S. Mellouk, M. Sedegah, T. Toyoshima, M. F. Leef, P. de la Vega, R. L. Beaudoin, M. Aikawa, V. Fallarme, and S. L. Hoffman. 1995. 17 kDa Plasmodium yoelii hepatic and erythrocytic stage proteins the target of protective antibodies. Exp. Parasitol. 80:419.
22. Charoenvit, Y., S. Mellouk, C. Cole, R. Bechara, M. F. Leef, M. Sedegah, L. F. Yuan, F. A. Robey, R. L. Beaudoin, and S. L. Hoffman. 1991. Monoclonal, but not polyclonal, antibodies, protect against Plasmodium yoelii sporozoites. J. Immunol. 146:1020.
23. Wang, R., Y. Charoenvit, G. Corradin, R. Porrozzi, R. L. Hunter, G. Glenn, C. R. Alving, P. Church, and S. L. Hoffman. 1995. Induction of protective polyclonal antibodies by immunization with a Plasmodium yoelii circumsporozoite protein multiple antigen peptide vaccine. J. Immunol. 154:2784.
24. Mellouk, S., S. J. Green, C. A. Nacy, and S. L. Hoffman. 1991. IFN- γinhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an L-arginine-dependent effector mechanism. J. Immunol. 146:3971.
25. Mellouk, S. O., S. L. Hoffman, Z. Z. Liu, P. de la Vega, T. R. Billiar, and A. K. Nussler. 1994. Nitric oxide-mediated antiplasmodial activity in human and murine hepatocytes induced by y interferon and the parasite itself: enhancement by exogenous tetrahydrobiopterin. Infect. Immun. 62:4043.
26. + T cells in the Plasmodium yoelii model. J. Immunol. 163:884.
27. Wang, R., D. L. Doolan, P. L. Thong, R. C. Hedstrom, K. M. Coonan, Y. Charoenvit, T. R. Jones, P. Hobart, M. Margalith, J. Ng, et al. 1998. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science 282:476.
28. Tang, D., M. DeVit, and S. A. Johnston. 1992. Genetic immunization is a simple method for eliciting an immune response. Nature 356:152.
29. Robinson, H. L., D. C. Montefiori, R. P. Johnson, K. H. Manson, M. L. Kalish, J. D. Lifson, T. A. Rizvi, S. Lu, S. L. Hu, G. P. Mazzara, et al. 1999. Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations. Nat. Med. 5:526.
30. + T cells mediated protective immunity against malaria. J. Immunol. 158:1268.
31. Guide for the Care and Use of Laboratory Animals. 1996. Institute of Laboratory Animal Resources Commission on Life Sciences, National Research Council, National Academy Press, Washington, DC. .