Live attenuated AIDS vaccines: Hazards and hopes

Nature Medicine

Volumn 5, Issue 2, 1999, Pages 154-155

  Johnson, R Paul ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS VACCINE; LIVE VACCINE; SIMIAN IMMUNODEFICIENCY VIRUS VACCINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADOLESCENT; BLOOD DISEASE; GENE DELETION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; NEWBORN; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; SHORT SURVEY; SIMIAN IMMUNODEFICIENCY VIRUS; THROMBOSIS; VACCINATION; VIRUS LOAD; VIRUS REPLICATION;

ADULT; AGING; AIDS VACCINES; ANIMALS; HIV; HUMANS; INFANT; LENTIVIRUS; SIMIAN IMMUNODEFICIENCY VIRUS; VACCINES, ATTENUATED; VACCINES, DNA; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0032938005     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/5515     Document Type: Short Survey

References (11)

1. Letvin, N.L. Progress in the development of an HIV-1 vaccine. Science 280, 1875-1880 (1998).
2. Daniel, M.D., Kirchhoff, F., Czajak, S.C., Sehgal, P.K. & Desrosiers, R.C. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 258, 1938-1941 (1992).
3. Wyand, M.S., Manson, K.H., Garcia-Moll, M., Montefiori, D. & Desrosiers, R.C. Vaccine protection by a triple-deletion mutant of simian immunodeficiency virus. J. Virol. 70, 3724-3733 (1996).
4. Baba, T.W. et al. Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques. Nature Med. 5, 194-203 (1999).
5. Kestler, H. W., III. et al. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65, 651-662 (1991).
6. Deacon, N.J. et al. Genomic structure of an attenuated quasi-species of HIV-1 from a blood transfusion donor and recipients. Science 270, 988-991 (1995).
7. Dyer, W.B. et al. Strong human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte activity in Sydney blood bank cohort patients infected with nef-defective HIV type 1. J. Virol. 73, 436-443 (1999).
8. Baba, T.W. et al. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267, 1820-1825 (1995).
9. Wyand, M.S., Manson, K.H., Lackner, A.A. & Desrosiers, R.C. Resistance of neonatal monkeys to live attenuated strains of simian immunodeficiency virus. Nature Med. 3, 32-36 (1997).
10. Connor, R.I. et al. Temporal analyses of virus replication, immune responses, and efficacy in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine. J. Virol. 72, 7501-7509 (1998).
11. Ruprecht, R.M., Baba, T.W., Rasmussen, R., Hu, Y. & Sharma, P.L. Murine and simian retrovirus models: The threshold hypothesis. AIDS 10 (suppl A), S33-S40 (1996).