Effective induction of simian immunodeficiency virus-specific systemic and mucosal immune responses in primates by vaccination with proviral DNA producing intact but noninfectious virions

Journal of Virology

Volumn 74, Issue 22, 2000, Pages 10514-10522

  Wang, S W ^a   Kozlowski, P A ^a   Schmelz, G ^a   Manson, K ^a   Wyand, M S ^a   Glickman, R ^a   Montefiori, D ^a   Lifson, J D ^a   Johnson, R P ^a   Neutra, M R ^a   Aldovini, A ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; IMMUNOGLOBULIN A; INACTIVATED VACCINE; SIMIAN IMMUNODEFICIENCY VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; INFECTION RESISTANCE; MUCOSAL IMMUNITY; NONHUMAN; PRIMATE; PRIORITY JOURNAL; RECTUM MUCOSA; RETROVIRUS INFECTION; SIMIAN IMMUNODEFICIENCY VIRUS; VACCINATION; VIRION; VIRUS INFECTIVITY;

ANIMALS; ANTIGENS, VIRAL; DNA, VIRAL; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; MACACA MULATTA; PROVIRUSES; SAIDS VACCINES; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; T-LYMPHOCYTES, CYTOTOXIC; VACCINATION; VACCINES, ATTENUATED; VACCINES, DNA; VIRION;

EID: 0033766990     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.22.10514-10522.2000     Document Type: Article

References (54)

1. Beta-chemokine production in macaques vaccinated with live attenuated virus correlates with protection against simian immunodeficiency virus (SIVsm) challenge
2. Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus
3. Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian/human immunodeficiency virus infection
4. Epidemiologic and biologic characterization of a cohort of human immunodeficiency virus type 1 highly exposed, persistently seronegative female sex workers in northern Thailand. Chiang Mai HEPS Working Group
5. Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients
6. A role for mucosal immunity in resistance to HIV infection
7. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
8. An essential interaction between distinct domains of HIV-1 integrase mediates assembly of the active multimer
9. Priming of cytotoxic T lymphocytes by DNA vaccines: Requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes
10. Long-term immunity and protection against herpes simplex virus type 2 in the murine female genital tract after mucosal but not systemic immunization
11. + nef-specific cytotoxic T cells in vaccinated macaques
12. Protection from pathogenic SIV challenge using multigenic DNA vaccines
13. Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen
14. Priming with tat-deleted caprine arthritis encephalitis virus (CAEV) proviral DNA or live virus protects goats from challenge with pathogenic CAEV
15. + T lymphocytes and preferential loss of memory cells on interaction of mononuclear cells with HIV-1 glycoprotein-expressing cells
16. Prolonged clinical latency and survival of macaques given a whole inactivated simian immunodeficiency virus vaccine
17. Gene splicing by overlap extension
18. DNA vaccination affords significant protection against feline immunodeficiency virus infection without inducing detectable antiviral antibodies
19. Nasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissues
20. Combined systemic and mucosal immunization with microsphere-encapsulated inactivated simian immunodeficiency virus elicits serum, vaginal, and tracheal antibody responses in female rhesus macaques
21. + T cell depletion in simian immunodeficiency virus-infected macaques
22. Induction of vigorous cytotoxic T lymphocyte responses by live attenuated simian immunodeficiency virus
23. Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: Inverse relationship of degree of protection with level of attenuation
24. Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus
25. Human immunodeficiency virus reverse transcriptase. Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coli
26. Mucosal or targeted lymph node immunization of macaques with a particulate SIVp27 protein elicits virus-specific CTL in the genito-rectal mucosa and draining lymph nodes
27. Modified wick method using Weck-Cel sponges for collection of human rectal secretions and analysis of mucosal HIV antibodies
28. CpG DNA: A novel immunomodulator
29. Oral immunization with simian immunodeficiency virus p55(gag) and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primates
30. Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus
31. Induction of mucosal and systemic immunity to a recombinant simian immunodeficiency viral protein
32. Targeted lymph node immunization with simian immunodeficiency virus p27 antigen to elicit genital, rectal, and urinary immune responses in nonhuman primates
33. Protective mucosal immunity elicited by targeted iliac lynph node immunization with a subunit SIV envelope and core vaccine in macaques
34. Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination
35. Targeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251
36. Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
37. Protection against vaginal SIV transmission with microencapsulated vaccine
38. Mechanism of genital transmission of SIV: A hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques
39. Progress towards a vaccine to prevent sexual transmission of HIV
40. Neutralizing and infection-enhancing antibody responses do not correlate with the differential pathogenicity of SIVmac239delta3 in adult and infant rhesus monkeys
41. Resistance to HIV infection among highly exposed sex workers in Nairobi: What mediates protection and why does it develop?
42. Nucleocapsid and matrix protein contributions to selective HIV-1 genomic RNA packaging
43. Charged amino acid residues of HIV-1 nucleocapsid p7 Protein involved in RNA packaging
44. The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus
45. Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations
46. + lymphocytes
47. Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells
48. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen
49. Plasma SIV RNA viral load determination by real-time quantification of product generation in reverse transcriptase-polymerase chain reaction
50. Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins
51. Improved DNA: Liposome complexes for increased systemic delivery and gene expression
52. Generation of monoclonal antibodies to Macaca mulatta (rhesus) IgA
53. Vaccine protection by a triple deletion mutant of simian immunodeficiency virus