Functional equivalency of B7-1 and B7-2 for costimulating plasmid DNA vaccine-elicited CTL responses

Journal of Immunology

Volumn 165, Issue 12, 2000, Pages 6791-6795

  Santra, S ^a   Barouch, D H ^a   Jackson, S S ^a   Kuroda, M J ^a   Schmitz, J E ^a   Lifton, M A ^a   Sharpe, A H ^a   Letvin, N L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; DNA VACCINE; EPITOPE; GLYCOPROTEIN GP 120; LIGAND; PLASMID DNA; SYNTHETIC PEPTIDE;

ANIMAL CELL; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNIZATION; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VACCINATION;

EID: 0034671608     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.12.6791     Document Type: Article

References (30)

1. Clonal expansion versus functional clonal inactivation a costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy
2. + T cells
3. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells
4. Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7
5. Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice
6. Cloning of B7-2 a CTLA-4 counter-receptor that costimulates human T cell proliferation
7. B70 antigen is a second ligand for CTLA-4 and CD28
8. CTLA-4 ligation blocks CD28-dependent T cell activation
9. CD80 (B7) and CD86 (B70) provide similar co-stimulatory signals for T cell proliferation, cytokine production, and generation of CTL
10. Role of costimulators in T cell differentiation stidies using antigen-presenting cells lacking expression of CDS0 or CD86
11. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
12. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways application to autoimmune disease therapy
13. B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity further evidence that B7-1 and B7-2 are functionally distinct
14. + T lymphocytes in the P815 tumor system in vitro
15. Differential requirement for CD80 and CD80/86-dependent costimulation in the lung immune response to an influenza virus infection
16. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
17. + cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus
18. B7-1 human (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
19. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells
20. Selective induction of B7/BB-1 on interferon-γ stimulated monocytes a potential mechanism for amplification of T cell activation
21. Differential up-regulation of the B7-1 and B7-2 costimulatory molecules following immunoglobulin receptor engagement by antigen
22. Heterologous and homologous protection against influenza A by DNA vaccination optimization of DNA vectors
23. Humoral and cellular immunities elicited by HIV-1 DNA vaccination
24. Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration
25. B7 costimulatory requirements differ for induction of immune responses by DNA, protein, and recombinant pox virus vaccination
26. Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant
27. Phenotypic analysis of antigen-specific T lymphocytes
28. Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex
29. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes
30. + T cells in primary and secondary influenza pneumonia