Delivery of multiple CD8 cytotoxic T cell epitopes by DNA vaccination

Journal of Immunology

Volumn 160, Issue 4, 1998, Pages 1717-1723

  Thomson, Scott A ^a   Sherritt, Martina A ^a   Medveczky, Jill ^b   Elliott, Suzanne L ^a   Moss, Denis J ^a   Fernando, Germain J P ^c   Brown, Lorena E ^d   Suhrbier, Andreas ^a,e  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DNA VACCINE; EPITOPE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MONOCLONAL ANTIBODY; PLASMID DNA; VIRUS HEMAGGLUTININ;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER TRANSPLANTATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; INFLUENZA VIRUS; INTRAMUSCULAR DRUG ADMINISTRATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOMA; VACCINATION; VACCINIA VIRUS; VIRUS INFECTION; VIRUS RECOMBINANT;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY FORMATION; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES, B-LYMPHOCYTE; EPITOPES, T-LYMPHOCYTE; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; IMMUNOLOGIC MEMORY; INFLUENZA A VIRUS; INJECTIONS, INTRAMUSCULAR; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NEOPLASM TRANSPLANTATION; PLASMIDS; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, HELPER-INDUCER; THYMOMA; VACCINATION; VACCINES, DNA; VACCINES, SYNTHETIC; VACCINIA VIRUS;

EID: 0032519428     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Khanna, R., Burrows, S., Kurilla, M., Jacob, C. A., Misko, I., Sculley, T. B., Kieff, E., and D. J. Moss. 1992. Localisation of Epstein-Barr virus CTL epitopes in healthy immune donors using recombinant vaccinia: implications for vaccine development. J. Exp. Med. 176:169.
2. Rowland-Jones, S., R. Tan, and A. McMichael. 1997. Role of cellular immunity in protection against HIV infection. Adv. Immunol. 65:277.
3. Maeurer, M. J., W. J. Storkus, J. M. Kirkwood, and M. T. Lotze. 1996. New treatment options for patients with melanoma: Review of melanoma-derived T-cell epitope-based vaccines. Melanoma Res. 6:11.
4. An, L. L., E. Pamer, and J. L. Whitton. 1996. A recombinant minigene vaccine containing a nonomeric cytotoxic-T-lymphocyte epitope confers limited protection against listeria monocytogenes infection. Infect. Immun. 64:1685.
5. Doolan, D. L., M. Sedegah, R. C. Hedstrom, P. Hobart, Y. Charoenvit, and S. L. Hoffman. 1996. Circumventing genetic restriction of protection against malaria with multigene DNA immunization - CD8(+) T cell-, interferon gamma-, and nitric oxide-dependent immunity. J. Exp. Med. 183:1739.
6. Gupta, R. K., and G. R. Siber. 1995. Adjuvants for human vaccines-current status, problems and future prospects. Vaccine 13:1263.
7. Ulmer, J. B., J. C. Sadoff, and M. A. Lui. 1996. DNA vaccines. Curr. Opin. Immunol. 8:531.
8. Jager, E., M. Ringhoffer, H. P. Dienes, M. Arand, J. Karbach, D. Jager, C. Ilsemann, M. Hagedorn, F. Oesch, and A. Knuth. 1996. Granulocyte-macrophage-colony-stimulating factor enhances immune responses to melanoma-associated peptides in vivo. Int. J. Cancer 67:54.
9. Wollinsky, S. M., B. T. M. Korber, A. U. Neumann, M. Daniels, K. J. Kunstman, A. J. Whetsell, M. R. Furtado, Y. Cao, D. D. Ho, J. T. Safrit, and R. A. Koup. 1996. Adaptive evolution of human immunodeficiency virus-type 1 during natural course of infection. Science 272:537.
10. Nomura, M., Y. Nakata, T. Inoue, A. Uzawa, S. Itamura, K. Nerome, M. Akashi, and G. Suzuki. 1996. In vivo induction of cytotoxic T lymphocytes specific for a single epitope introduced into an unrelated molecule. J. Immunol. Methods 193:41.
11. Ciernik, I. F., J. A. Berzofsky, and D. P. Carbone. 1996. Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes. J. Immunol. 156:2369.
12. Eaton, D. L., W. I. Wood, D. Eaton, P. E. Hass, P. Hollingshead, K. Wion, J. Mather, R. M. Lawn, G. A. Vehar, and C. Gorman. 1986. Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule. Biochemistry 25:8343.
13. Vieira, J., and J. Messing. 1982. The pUC plasmids, an M13 mp7-derived system for insertion mutagenisis and sequencing with synthetic universal primers. Gene 19:259.
14. Thomson, S. A., S. L. Elliott, M. A. Sherritt, K. W. Sproat, B. E. H. Coupar, A. A. Scalzo, C. A. Forbes, A. M. Ladhams, X. Y. Mo, R. A. Tripp, P. C. Doherty, D. J. Moss, and A. Suhrbier. 1996. Recombinant polyepitope vaccines for the delivery of multiple CD8 cytotoxic T cell epitopes. J. Immunol. 157:822.
15. Johnson, G. R., T. J. Gonda, D. Metcalf, I. K. Hariharan, and S. Cory. 1989. A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor. EMBO J. 8:441.
16. Long, E. O., S. Rosen-Bronson, D. R. Karp, M. Malnati, R. P. Sekaly, and D. Jaraquemada. 1991. Efficient cDNA expression vectors for stable and transient expression of HLA-DR in transfected fibroblast and lymphoid cells. Hum. Immunol. 31:229.
17. Fynan, E. F., R. G. Webster, D. H. Fuller, J. R. Haynes, J. C. Santoro, and H. L. Robinson. 1993. DNA vaccines: protective immunizations by parenteral, mucosal, and gene gun innoculations. Proc. Natl. Acad. Sci. USA 90:11478.
18. Pertmer T. M., M. D. Eisenbraun, D. McCabe, S. K. Prayaga, D. H. Fuller, and J. R. Haynes. 1995. Gene gun-based nucleic acid immunization: elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA. Vaccine 13:1427.
19. Moore, M. W., F. R. Carbone, and M. J. Bevan. 1988. Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell 54:777.
20. Gaush, C. R., and T. F. Smith. 1968. Replication and plaque assay of influenza virus in an established line of canine kidney cells. Appl. Microbiol. 16:588.
21. Brown, L. E., J. M. Murray, E. M. Anders, X-L, Tang, D. O. White, G. W. Tregear, and D. C. Jackson. 1988. Genetic control and fine specificity of the immune response to a synthetic peptide of influenza virus hemagglutinin. J. Virol. 62:1746.
22. + T cells by anti-CD4 monoclonal antibody (GK1.5) in young and aged mice. J. Immunol. 154:6644.
23. Herd, K., G. J. P. Fernando, L. A. Dunn, I. H. Frazer, P. Lambert, and R. W. Tindle. 1997. E7 onocprotein of human papillomavirus type 16 expressed constitutively in the epidermis has no effect on E7-specific B- or Th-repertoires or on the immune response induced or sustained after immunization with E7 protein. Virology 231:155.
24. + cytotoxic T cells: implications for vaccine design. Proc. Natl. Acad. Sci. USA 92:5845.
25. Kara, U., B. Murray, C. Pam, J. Lahnstein, H. Gould, C. Kidson, and A. Saul. 1990. Chemical characterization of the vacuole membrane antigen QF 116 from Plasmodium falciparum. Mol. Biol. Parasitol. 38:19.
26. Kara, U., D. Pye, R. Lord, C. Pam, H. Gould, M. Geysen, G. Jones, D. Stenzel, C. Kidson, and A. Saul. 1989. Immune response to a synthetic peptide corresponding to an epitope of a parasitophorous vacuole membrane antigen from Plasmodium falciparum. J. Immunol. 143:1334.
27. Lawson, C., J. R. Bennink, N. P. Restifo, J. W. Yewdell, and B. R. Murphy. 1994. Primary pulmonary cytotoxic T lymphocytes induced by immunization with a vaccinia virus recombinant expressing influenza A virus nucleoprotein peptide do not protect mice against challenge. J. Virol. 68:3505.
28. Sastry, K. J., B. S. Bender, W. Bell, P. A. Small, and R. B. Arlinghaus. 1994. Effects of influenza virus-specific cytotoxic T-lymphocyte responses induced by a synthetic nucleoprotein peptide on the survival of mice challenged with a lethal dose of virus. Vaccine 12:1281.
29. Baumgarth, N., and A. Kelso. 1996. In vivo blockade of gamma interferon affects the influenza virus-induced humoral and the focal cellular immune response in lung tissue. J. Virol. 70:4411.
30. Xiang, Z., and H. C. J. Ertl. 1995. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2:129.
31. Ahmed, R., and D. Gray D. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54.
32. Di Rosa, F., and Matzinger, P. 1996. Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells. J. Exp. Med. 183:2153.
33. Suhrbier, A. 1997. Multi-epitope DNA vaccines. Immunol. Cell Biol. 75:402.
34. + T lymphocytes. J. Immunol. 151: 5993.
35. + cytotoxic T-cell responses during chronic viral infection. J. Virol. 68:8056.
36. von Herrath M. G., M. Yokoyama, J. Dockter, M. B. Oldstone, and J. L. Whitton. 1996. CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge. J. Virol. 70:1072.
37. Sato, Y., M. Roman, H. Tighe, D. Lee, M. Corr, M. Nguyen, G. J. Silverman, M. Lotz, D. A. Carson, and E. Raz. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352.
38. Cella, M., D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
39. Bianchi, R., U. Grohmann, M. L. Belladonna, S. Silla, F. Fallarino, E. Ayroldi, M. C. Fioretti, and P. Puccetti. 1996. IL-12 is both required and sufficient for initiating T cell reactivity to a class I-restricted tumor peptide (P815AB) following transfer of P815AB-pulsed dendritic cells. J. Immunol. 157:1589.
40. Geissler, M., A. Gesien, K. Tokushige, J. R. Wands. 1997. Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids. J. Immunol. 158:1231.
41. Kim, J. J., V. Ayyavoo, M. L. Bagarazzi, M. A. Chattergoon, K. Dang, B. Wang, J. D. Boyer, and D. B. J. Weiner. 1997. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. J. Immunol. 158:816.
42. Ulmer, J. B., R. R. Deck, C. M. Dewitt, J. I. Donnelly, and M. A. Liu. 1996. Generation of MHC class I-restricted cytotoxic T lymphocytes by expression of a viral protein in muscle cells: antigen presentation by non-muscle cells. Immunology 89:59.
43. An, L. L., and J. L. Whitton. 1997. A mulivalent minigene vaccine, containing B-cell, cytotoxic T-Lymphocyte, and Th epitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen. J. Virol. 71:2292.
44. Moss, D. J., C. Schmidt, S. L. Elliott, A. Suhrbier, S. R. Burrows, and R. Khanna. 1996. Strategies involved in developing an effective vaccine to EBV-associated diseases. Adv. Can. Res. 69:213.
45. Goulder P. J. R., R. E. Phillips, R. A. Colbert, S. McAdam, G. Ogg, M. A. Nowak, P. Giangrande, G. Luzzi, B. Morgan, A. Edwards, A. J. McMichael, S. Rowland-Jones. 1997. Late escape from an immunodominant cyotoxic T-lymphocyte response associated with progression to AIDS. Nat. Med. 3:212.
46. Borrow P., H. Lewicki, X. P. Wei., M. S. Horwitz, N. Peffer, H. Meyers. J. A. Nelson, J. E. Gairin, B. H. Hahn, M. B. A. Oldstone, and G. M. Shaw. 1997. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat. Med. 3:205.
47. Elliott, T., M. Smith, P. Driscoll, and A. McMichael. 1993. Peptide selection by class I molecules of the major histocompatibility complex. Curr. Biol. 3:854.